Efficacy of two-month treatment with Xiloial® eyedrops for discomfort from disposable soft contact lenses

Efficacy of two-month treatment with Xiloial® eyedrops for discomfort from disposable soft contact lenses

Piera Versura, Vincenzo Profazio, Nicole Balducci, Emilio C CamposOphthalmology Unit, Alma Mater Studiorum University of Bologna, Bologna, ItalyPurpose: To evaluate the efficacy and tolerability of Xiloial® monodose eyedrops in the treatment of patients suffering from subjective symptoms...

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Autores principales: Piera Versura, Vincenzo Profazio, Nicole Balducci, et al
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2010
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Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/65f88501baa14bb5977d3a27ae96ea54
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spelling oai:doaj.org-article:65f88501baa14bb5977d3a27ae96ea542021-12-02T01:30:08ZEfficacy of two-month treatment with Xiloial® eyedrops for discomfort from disposable soft contact lenses1177-54671177-5483https://doaj.org/article/65f88501baa14bb5977d3a27ae96ea542010-09-01T00:00:00Zhttp://www.dovepress.com/efficacy-of-two-month-treatment-with-xiloialreg-eyedrops-for-discomfor-a5298https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Piera Versura, Vincenzo Profazio, Nicole Balducci, Emilio C CamposOphthalmology Unit, Alma Mater Studiorum University of Bologna, Bologna, ItalyPurpose: To evaluate the efficacy and tolerability of Xiloial® monodose eyedrops in the treatment of patients suffering from subjective symptoms of discomfort related to disposable soft contact lens (dSCL) wear.Methods: Fifteen (12 female, three male, medium age 39 ± 9 years) dSCL wearers were enrolled. Inclusion criteria were Ocular Surface Disease Index (ODSI) symptom questionnaire score >12, tear film break-up time (TFBUT) <10 sec, Schirmer test I >10 mm over five minutes, mild punctuate keratopathy, and conjunctival staining (Oxford grading ≤4). Monodose Xiloial eyedrops were administered three times daily for a two-month period. Patients were evaluated at enrollment, after three days of washout (baseline), and after one and two months of treatment, by OSDI score, Schirmer test I, TFBUT, ferning test, ocular surface damage (Oxford grade), and serum albumin in tears (index of passive exudation related to serum leakage).Results: At endpoint versus baseline, respectively, the mean ± standard deviation of all variables improved as follows: OSDI (8.5 ± 3 versus 20.2 ± 1.6); TFBUT (9.6 ± 1.1 versus 7.1 ± 1.0); Oxford grading (0.5 ± 0.1 versus 3.6 ± 0.8); ferning test (2 ± 1 versus 2.4 ± 0.5); and Schirmer test I (14.6 ± 1.1 versus 12 ± 2.1), with P < 0.05 for all variables (Friedman and Wilcoxon tests). Tolerability was high, with no adverse events noted.Conclusions: A two-month treatment with Xiloial showed good tolerance and appeared to reduce ocular surface damage and symptoms of discomfort.Keywords: discomfort, dry eye, disposable contact lens, biopolymer tamarind seed polysaccharide–hyaluronic acid Piera VersuraVincenzo ProfazioNicole Balducciet alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 1035-1041 (2010)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Piera Versura
Vincenzo Profazio
Nicole Balducci
et al
Efficacy of two-month treatment with Xiloial® eyedrops for discomfort from disposable soft contact lenses
description Piera Versura, Vincenzo Profazio, Nicole Balducci, Emilio C CamposOphthalmology Unit, Alma Mater Studiorum University of Bologna, Bologna, ItalyPurpose: To evaluate the efficacy and tolerability of Xiloial® monodose eyedrops in the treatment of patients suffering from subjective symptoms of discomfort related to disposable soft contact lens (dSCL) wear.Methods: Fifteen (12 female, three male, medium age 39 ± 9 years) dSCL wearers were enrolled. Inclusion criteria were Ocular Surface Disease Index (ODSI) symptom questionnaire score >12, tear film break-up time (TFBUT) <10 sec, Schirmer test I >10 mm over five minutes, mild punctuate keratopathy, and conjunctival staining (Oxford grading ≤4). Monodose Xiloial eyedrops were administered three times daily for a two-month period. Patients were evaluated at enrollment, after three days of washout (baseline), and after one and two months of treatment, by OSDI score, Schirmer test I, TFBUT, ferning test, ocular surface damage (Oxford grade), and serum albumin in tears (index of passive exudation related to serum leakage).Results: At endpoint versus baseline, respectively, the mean ± standard deviation of all variables improved as follows: OSDI (8.5 ± 3 versus 20.2 ± 1.6); TFBUT (9.6 ± 1.1 versus 7.1 ± 1.0); Oxford grading (0.5 ± 0.1 versus 3.6 ± 0.8); ferning test (2 ± 1 versus 2.4 ± 0.5); and Schirmer test I (14.6 ± 1.1 versus 12 ± 2.1), with P < 0.05 for all variables (Friedman and Wilcoxon tests). Tolerability was high, with no adverse events noted.Conclusions: A two-month treatment with Xiloial showed good tolerance and appeared to reduce ocular surface damage and symptoms of discomfort.Keywords: discomfort, dry eye, disposable contact lens, biopolymer tamarind seed polysaccharide–hyaluronic acid
format article
author Piera Versura
Vincenzo Profazio
Nicole Balducci
et al
author_facet Piera Versura
Vincenzo Profazio
Nicole Balducci
et al
author_sort Piera Versura
title Efficacy of two-month treatment with Xiloial® eyedrops for discomfort from disposable soft contact lenses
title_short Efficacy of two-month treatment with Xiloial® eyedrops for discomfort from disposable soft contact lenses
title_full Efficacy of two-month treatment with Xiloial® eyedrops for discomfort from disposable soft contact lenses
title_fullStr Efficacy of two-month treatment with Xiloial® eyedrops for discomfort from disposable soft contact lenses
title_full_unstemmed Efficacy of two-month treatment with Xiloial® eyedrops for discomfort from disposable soft contact lenses
title_sort efficacy of two-month treatment with xiloial® eyedrops for discomfort from disposable soft contact lenses
publisher Dove Medical Press
publishDate 2010
url https://doaj.org/article/65f88501baa14bb5977d3a27ae96ea54
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AT nicolebalducci efficacyoftwomonthtreatmentwithxiloialampregeyedropsfordiscomfortfromdisposablesoftcontactlenses
AT etal efficacyoftwomonthtreatmentwithxiloialampregeyedropsfordiscomfortfromdisposablesoftcontactlenses
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