Data Mining of Free-Text Responses: An Innovative Approach to Analyzing Patient Perspectives on Treatment for Chronic Rhinosinusitis with Nasal Polyps in a Phase IIa Proof-of-Concept Study for Dupilumab

Asif H Khan,1 Adeline Abbe,1 Bruno Falissard,2 Paulo Carita,1 Claus Bachert,3,4 Joaquim Mullol,5 Matthew Reaney,6 Jingdong Chao,7 Leda P Mannent,1 Nikhil Amin,7 Puneet Mahajan,8 Gianluca Pirozzi,8 Laurent Eckert1 1Sanofi, Chilly-Mazarin, France; 2Centre de recherche en epidémiologie et santé des pop...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Khan AH, Abbe A, Falissard B, Carita P, Bachert C, Mullol J, Reaney M, Chao J, Mannent LP, Amin N, Mahajan P, Pirozzi G, Eckert L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	crswnp free-text data mining patient perspective self-assessment sense of smell Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/65fe2b8f5bdb44fa9671ebbbfceae157
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:65fe2b8f5bdb44fa9671ebbbfceae157
record_format	dspace
spelling	oai:doaj.org-article:65fe2b8f5bdb44fa9671ebbbfceae1572021-11-21T19:08:50ZData Mining of Free-Text Responses: An Innovative Approach to Analyzing Patient Perspectives on Treatment for Chronic Rhinosinusitis with Nasal Polyps in a Phase IIa Proof-of-Concept Study for Dupilumab1177-889Xhttps://doaj.org/article/65fe2b8f5bdb44fa9671ebbbfceae1572021-11-01T00:00:00Zhttps://www.dovepress.com/data-mining-of-free-text-responses-an-innovative-approach-to-analyzing-peer-reviewed-fulltext-article-PPAhttps://doaj.org/toc/1177-889XAsif H Khan,1 Adeline Abbe,1 Bruno Falissard,2 Paulo Carita,1 Claus Bachert,3,4 Joaquim Mullol,5 Matthew Reaney,6 Jingdong Chao,7 Leda P Mannent,1 Nikhil Amin,7 Puneet Mahajan,8 Gianluca Pirozzi,8 Laurent Eckert1 1Sanofi, Chilly-Mazarin, France; 2Centre de recherche en epidémiologie et santé des populations (CESP), INSERM U1018, Paris, France; 3Upper Airways Research Laboratory, Ghent University, Ghent, Belgium; 4CLINTEC, Karolinska Institutet, Stockholm, Sweden; 5Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Universitat de Barcelona; Clinical and Experimental Respiratory Immunoallergy, IDIBAPS; and CIBERES, Barcelona, Catalonia, Spain; 6IQVIA, Reading, UK; 7Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA; 8Sanofi, Bridgewater, NJ, USACorrespondence: Asif H KhanSanofi, 1 Avenue Pierre Brossolette, Chilly-Mazarin, 91380, FranceTel +33 1 60 49 77 77Email asif.khan@sanofi.comPurpose: Patient perspective is an important and increasingly sought-after complement to clinical assessment. The aim of this study was to transcribe individual patients’ experience of treatment in a dupilumab clinical trial through free-text responses with analysis using natural language processing (NLP) to obtain the unique perspective of patients on disease impact and unmet needs with existing treatment to inform future trial design.Patients and Methods: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) who were enrolled in a Phase IIa randomized controlled trial comparing dupilumab with placebo (NCT01920893) were invited to complete a self-assessment of treatment (SAT) tool at the end of treatment, asking, “What is your opinion on the treatment you had during the trial? What did you like or dislike about the treatment?” Free-text responses were analyzed for the overall cohort and according to treatment assignment using natural language processing including sentiment scoring. In a mixed-methods approach, quantitative patient-reported outcome (PRO) results were utilized to complement the qualitative analysis of free-text responses.Results: Of 60 patients enrolled in the study, 43 (71.6%) completed the SAT and responses from 37 patients were analyzed (placebo, n = 16; dupilumab, n = 21). Word analyses showed that the most common words were “smell,” “improve,” “staff,” “great,” “time,” and “good.” Across the whole cohort, “smell” was the most common symptom-related word. The words “smell” and “experience” were more likely to occur in patients treated with dupilumab. Patients treated with dupilumab also had more positive sentiment in their SAT responses than those who received placebo. The results from this qualitative analysis were reflected in quantitative PRO results.Conclusion: “Smell” was important to patients with CRSwNP, highlighting its importance as a patient-centric efficacy outcome measure in the context of clinical trials in CRSwNP.Trial Registration: ClinicalTrials.gov, NCT01920893. Registered 12 August 2013, https://www.clinicaltrials.gov/ct2/show/NCT01920893.Keywords: CRSwNP, free-text data mining, patient perspective, self-assessment, sense of smellKhan AHAbbe AFalissard BCarita PBachert CMullol JReaney MChao JMannent LPAmin NMahajan PPirozzi GEckert LDove Medical Pressarticlecrswnpfree-text data miningpatient perspectiveself-assessmentsense of smellMedicine (General)R5-920ENPatient Preference and Adherence, Vol Volume 15, Pp 2577-2586 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	crswnp free-text data mining patient perspective self-assessment sense of smell Medicine (General) R5-920
spellingShingle	crswnp free-text data mining patient perspective self-assessment sense of smell Medicine (General) R5-920 Khan AH Abbe A Falissard B Carita P Bachert C Mullol J Reaney M Chao J Mannent LP Amin N Mahajan P Pirozzi G Eckert L Data Mining of Free-Text Responses: An Innovative Approach to Analyzing Patient Perspectives on Treatment for Chronic Rhinosinusitis with Nasal Polyps in a Phase IIa Proof-of-Concept Study for Dupilumab
description	Asif H Khan,1 Adeline Abbe,1 Bruno Falissard,2 Paulo Carita,1 Claus Bachert,3,4 Joaquim Mullol,5 Matthew Reaney,6 Jingdong Chao,7 Leda P Mannent,1 Nikhil Amin,7 Puneet Mahajan,8 Gianluca Pirozzi,8 Laurent Eckert1 1Sanofi, Chilly-Mazarin, France; 2Centre de recherche en epidémiologie et santé des populations (CESP), INSERM U1018, Paris, France; 3Upper Airways Research Laboratory, Ghent University, Ghent, Belgium; 4CLINTEC, Karolinska Institutet, Stockholm, Sweden; 5Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Universitat de Barcelona; Clinical and Experimental Respiratory Immunoallergy, IDIBAPS; and CIBERES, Barcelona, Catalonia, Spain; 6IQVIA, Reading, UK; 7Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA; 8Sanofi, Bridgewater, NJ, USACorrespondence: Asif H KhanSanofi, 1 Avenue Pierre Brossolette, Chilly-Mazarin, 91380, FranceTel +33 1 60 49 77 77Email asif.khan@sanofi.comPurpose: Patient perspective is an important and increasingly sought-after complement to clinical assessment. The aim of this study was to transcribe individual patients’ experience of treatment in a dupilumab clinical trial through free-text responses with analysis using natural language processing (NLP) to obtain the unique perspective of patients on disease impact and unmet needs with existing treatment to inform future trial design.Patients and Methods: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) who were enrolled in a Phase IIa randomized controlled trial comparing dupilumab with placebo (NCT01920893) were invited to complete a self-assessment of treatment (SAT) tool at the end of treatment, asking, “What is your opinion on the treatment you had during the trial? What did you like or dislike about the treatment?” Free-text responses were analyzed for the overall cohort and according to treatment assignment using natural language processing including sentiment scoring. In a mixed-methods approach, quantitative patient-reported outcome (PRO) results were utilized to complement the qualitative analysis of free-text responses.Results: Of 60 patients enrolled in the study, 43 (71.6%) completed the SAT and responses from 37 patients were analyzed (placebo, n = 16; dupilumab, n = 21). Word analyses showed that the most common words were “smell,” “improve,” “staff,” “great,” “time,” and “good.” Across the whole cohort, “smell” was the most common symptom-related word. The words “smell” and “experience” were more likely to occur in patients treated with dupilumab. Patients treated with dupilumab also had more positive sentiment in their SAT responses than those who received placebo. The results from this qualitative analysis were reflected in quantitative PRO results.Conclusion: “Smell” was important to patients with CRSwNP, highlighting its importance as a patient-centric efficacy outcome measure in the context of clinical trials in CRSwNP.Trial Registration: ClinicalTrials.gov, NCT01920893. Registered 12 August 2013, https://www.clinicaltrials.gov/ct2/show/NCT01920893.Keywords: CRSwNP, free-text data mining, patient perspective, self-assessment, sense of smell
format	article
author	Khan AH Abbe A Falissard B Carita P Bachert C Mullol J Reaney M Chao J Mannent LP Amin N Mahajan P Pirozzi G Eckert L
author_facet	Khan AH Abbe A Falissard B Carita P Bachert C Mullol J Reaney M Chao J Mannent LP Amin N Mahajan P Pirozzi G Eckert L
author_sort	Khan AH
title	Data Mining of Free-Text Responses: An Innovative Approach to Analyzing Patient Perspectives on Treatment for Chronic Rhinosinusitis with Nasal Polyps in a Phase IIa Proof-of-Concept Study for Dupilumab
title_short	Data Mining of Free-Text Responses: An Innovative Approach to Analyzing Patient Perspectives on Treatment for Chronic Rhinosinusitis with Nasal Polyps in a Phase IIa Proof-of-Concept Study for Dupilumab
title_full	Data Mining of Free-Text Responses: An Innovative Approach to Analyzing Patient Perspectives on Treatment for Chronic Rhinosinusitis with Nasal Polyps in a Phase IIa Proof-of-Concept Study for Dupilumab
title_fullStr	Data Mining of Free-Text Responses: An Innovative Approach to Analyzing Patient Perspectives on Treatment for Chronic Rhinosinusitis with Nasal Polyps in a Phase IIa Proof-of-Concept Study for Dupilumab
title_full_unstemmed	Data Mining of Free-Text Responses: An Innovative Approach to Analyzing Patient Perspectives on Treatment for Chronic Rhinosinusitis with Nasal Polyps in a Phase IIa Proof-of-Concept Study for Dupilumab
title_sort	data mining of free-text responses: an innovative approach to analyzing patient perspectives on treatment for chronic rhinosinusitis with nasal polyps in a phase iia proof-of-concept study for dupilumab
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/65fe2b8f5bdb44fa9671ebbbfceae157
work_keys_str_mv	AT khanah dataminingoffreetextresponsesaninnovativeapproachtoanalyzingpatientperspectivesontreatmentforchronicrhinosinusitiswithnasalpolypsinaphaseiiaproofofconceptstudyfordupilumab AT abbea dataminingoffreetextresponsesaninnovativeapproachtoanalyzingpatientperspectivesontreatmentforchronicrhinosinusitiswithnasalpolypsinaphaseiiaproofofconceptstudyfordupilumab AT falissardb dataminingoffreetextresponsesaninnovativeapproachtoanalyzingpatientperspectivesontreatmentforchronicrhinosinusitiswithnasalpolypsinaphaseiiaproofofconceptstudyfordupilumab AT caritap dataminingoffreetextresponsesaninnovativeapproachtoanalyzingpatientperspectivesontreatmentforchronicrhinosinusitiswithnasalpolypsinaphaseiiaproofofconceptstudyfordupilumab AT bachertc dataminingoffreetextresponsesaninnovativeapproachtoanalyzingpatientperspectivesontreatmentforchronicrhinosinusitiswithnasalpolypsinaphaseiiaproofofconceptstudyfordupilumab AT mullolj dataminingoffreetextresponsesaninnovativeapproachtoanalyzingpatientperspectivesontreatmentforchronicrhinosinusitiswithnasalpolypsinaphaseiiaproofofconceptstudyfordupilumab AT reaneym dataminingoffreetextresponsesaninnovativeapproachtoanalyzingpatientperspectivesontreatmentforchronicrhinosinusitiswithnasalpolypsinaphaseiiaproofofconceptstudyfordupilumab AT chaoj dataminingoffreetextresponsesaninnovativeapproachtoanalyzingpatientperspectivesontreatmentforchronicrhinosinusitiswithnasalpolypsinaphaseiiaproofofconceptstudyfordupilumab AT mannentlp dataminingoffreetextresponsesaninnovativeapproachtoanalyzingpatientperspectivesontreatmentforchronicrhinosinusitiswithnasalpolypsinaphaseiiaproofofconceptstudyfordupilumab AT aminn dataminingoffreetextresponsesaninnovativeapproachtoanalyzingpatientperspectivesontreatmentforchronicrhinosinusitiswithnasalpolypsinaphaseiiaproofofconceptstudyfordupilumab AT mahajanp dataminingoffreetextresponsesaninnovativeapproachtoanalyzingpatientperspectivesontreatmentforchronicrhinosinusitiswithnasalpolypsinaphaseiiaproofofconceptstudyfordupilumab AT pirozzig dataminingoffreetextresponsesaninnovativeapproachtoanalyzingpatientperspectivesontreatmentforchronicrhinosinusitiswithnasalpolypsinaphaseiiaproofofconceptstudyfordupilumab AT eckertl dataminingoffreetextresponsesaninnovativeapproachtoanalyzingpatientperspectivesontreatmentforchronicrhinosinusitiswithnasalpolypsinaphaseiiaproofofconceptstudyfordupilumab
_version_	1718418705516331008

Data Mining of Free-Text Responses: An Innovative Approach to Analyzing Patient Perspectives on Treatment for Chronic Rhinosinusitis with Nasal Polyps in a Phase IIa Proof-of-Concept Study for Dupilumab

Ejemplares similares