Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy
Polyetheretherketone (PEEK) has been widely used as orthopedic and dental materials due to excellent mechanical and physicochemical tolerance. However, its biological inertness, poor osteoinduction, and weak antibacterial activity make the clinical applications in a dilemma. Inspired by the mussel a...
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KeAi Communications Co., Ltd.
2022
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oai:doaj.org-article:66086072369b4c638e2c240e5b7cf23e2021-11-04T04:36:28ZRational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy2452-199X10.1016/j.bioactmat.2021.07.002https://doaj.org/article/66086072369b4c638e2c240e5b7cf23e2022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21003236https://doaj.org/toc/2452-199XPolyetheretherketone (PEEK) has been widely used as orthopedic and dental materials due to excellent mechanical and physicochemical tolerance. However, its biological inertness, poor osteoinduction, and weak antibacterial activity make the clinical applications in a dilemma. Inspired by the mussel adhesion mechanism, here we reported a biomimetic surface strategy for rational integration and optimization of anti-infectivity and osteo-inductivity onto PEEK surfaces using a mussel foot proteins (Mfps)-mimic peptide with clickable azido terminal. The peptide enables mussel-like adhesion on PEEK biomaterial surfaces, leaving azido groups for the further steps of biofunctionalizations. In this study, antimicrobial peptide (AMP) and osteogenic growth peptide (OGP) were bioorthogonally clicked on the azido-modified PEEK biomaterials to obtain a dual-effect of host defense and tissue repair. Since bioorthogonal clicking allows precise collocation between AMP and OGP through changing their feeding molar ratios, an optimal PEEK surface was finally obtained in this research, which could long-term inhibit bacterial growth, stabilize bone homeostasis and facilitate interfacial bone regeneration. In a word, this upgraded mussel surface strategy proposed in this study is promising for the surface bioengineering of inert medical implants, in particular, achieving rational integration of multiple biofunctions to match clinical requirements.Meng LiJiaxiang BaiHuaqiang TaoLi HaoWeiling YinXiaoxue RenAng GaoNing LiMiao WangShiyuan FangYaozeng XuLiang ChenHuilin YangHuaiyu WangGuoqing PanDechun GengKeAi Communications Co., Ltd.articleSurface biomodificationPolyetheretherketoneAnti-infectivity and osteo-inductivityMussel adhesionBioorthogonal chemistryMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 8, Iss , Pp 309-324 (2022) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Surface biomodification Polyetheretherketone Anti-infectivity and osteo-inductivity Mussel adhesion Bioorthogonal chemistry Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 |
| spellingShingle |
Surface biomodification Polyetheretherketone Anti-infectivity and osteo-inductivity Mussel adhesion Bioorthogonal chemistry Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Meng Li Jiaxiang Bai Huaqiang Tao Li Hao Weiling Yin Xiaoxue Ren Ang Gao Ning Li Miao Wang Shiyuan Fang Yaozeng Xu Liang Chen Huilin Yang Huaiyu Wang Guoqing Pan Dechun Geng Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy |
| description |
Polyetheretherketone (PEEK) has been widely used as orthopedic and dental materials due to excellent mechanical and physicochemical tolerance. However, its biological inertness, poor osteoinduction, and weak antibacterial activity make the clinical applications in a dilemma. Inspired by the mussel adhesion mechanism, here we reported a biomimetic surface strategy for rational integration and optimization of anti-infectivity and osteo-inductivity onto PEEK surfaces using a mussel foot proteins (Mfps)-mimic peptide with clickable azido terminal. The peptide enables mussel-like adhesion on PEEK biomaterial surfaces, leaving azido groups for the further steps of biofunctionalizations. In this study, antimicrobial peptide (AMP) and osteogenic growth peptide (OGP) were bioorthogonally clicked on the azido-modified PEEK biomaterials to obtain a dual-effect of host defense and tissue repair. Since bioorthogonal clicking allows precise collocation between AMP and OGP through changing their feeding molar ratios, an optimal PEEK surface was finally obtained in this research, which could long-term inhibit bacterial growth, stabilize bone homeostasis and facilitate interfacial bone regeneration. In a word, this upgraded mussel surface strategy proposed in this study is promising for the surface bioengineering of inert medical implants, in particular, achieving rational integration of multiple biofunctions to match clinical requirements. |
| format |
article |
| author |
Meng Li Jiaxiang Bai Huaqiang Tao Li Hao Weiling Yin Xiaoxue Ren Ang Gao Ning Li Miao Wang Shiyuan Fang Yaozeng Xu Liang Chen Huilin Yang Huaiyu Wang Guoqing Pan Dechun Geng |
| author_facet |
Meng Li Jiaxiang Bai Huaqiang Tao Li Hao Weiling Yin Xiaoxue Ren Ang Gao Ning Li Miao Wang Shiyuan Fang Yaozeng Xu Liang Chen Huilin Yang Huaiyu Wang Guoqing Pan Dechun Geng |
| author_sort |
Meng Li |
| title |
Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy |
| title_short |
Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy |
| title_full |
Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy |
| title_fullStr |
Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy |
| title_full_unstemmed |
Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy |
| title_sort |
rational integration of defense and repair synergy on peek osteoimplants via biomimetic peptide clicking strategy |
| publisher |
KeAi Communications Co., Ltd. |
| publishDate |
2022 |
| url |
https://doaj.org/article/66086072369b4c638e2c240e5b7cf23e |
| work_keys_str_mv |
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| _version_ |
1718445276647129088 |