Protective Effects of Shrimp Peptide on Dextran Sulfate Sodium-Induced Colitis in Mice

Inflammatory bowel disease, an intestinal relapsing inflammatory disease, not only impairs gastrointestinal function but also increases the chances of developing colon cancer. Currently, the effects of shrimp peptide (SP) in mice model of ulcerative colitis (UC) are still unclear. In particular, it...

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Autores principales:	Xingwei Xiang, Qihong Jiang, Wan Shao, Jinhong Li, Yufang Zhou, Lin Chen, Shanggui Deng, Bin Zheng, Yufeng Chen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	shrimp peptides dextran sulfate sodium (DSS) ulcerative colitis inflammatory bowel disease intestinal flora Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/6608862f829b4fe98e6dd05b3a4c7550
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spelling	oai:doaj.org-article:6608862f829b4fe98e6dd05b3a4c75502021-11-30T18:57:31ZProtective Effects of Shrimp Peptide on Dextran Sulfate Sodium-Induced Colitis in Mice2296-861X10.3389/fnut.2021.773064https://doaj.org/article/6608862f829b4fe98e6dd05b3a4c75502021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.773064/fullhttps://doaj.org/toc/2296-861XInflammatory bowel disease, an intestinal relapsing inflammatory disease, not only impairs gastrointestinal function but also increases the chances of developing colon cancer. Currently, the effects of shrimp peptide (SP) in mice model of ulcerative colitis (UC) are still unclear. In particular, it is uncertain whether SP affects the gut flora with UC mice. In this study, we investigated the anti-inflammatory effects of SP on a dextran sulfate sodium (DSS)-induced mouse model of UC. Firstly, the molecular weight of SP was mainly distributed in the range of 180–1,000 Da (61.95% proportion), and the amino acid composition showed that SP contained 17 amino acids, of which, the essential amino acids accounted for 54.50%. In vivo, oral SP significantly attenuated the severity of colitis, such as diarrhea, weight loss, and rectal bleeding. Furthermore, treatment with SP remarkably ameliorated intestinal barrier integrity, thus lowering the levels of the inflammatory cytokines and ameliorating antioxidant indices and intestinal injury indicators in the serum and colon. Lastly, the cecal contents were used to sequence and analyze the 16S rRNA genes of bacteria. Results suggested that treatment with SP could restore the balance of intestinal flora in modeled mice by regulating the abundance of pathogenic and beneficial bacteria. Furthermore, SP could significantly improve intestinal flora dysfunction in mice with UC. In summary, our findings show that SP has a prophylactic and therapeutic effect in UC in vivo, thereby highlighting its broad medicinal applications.Xingwei XiangXingwei XiangXingwei XiangQihong JiangQihong JiangQihong JiangWan ShaoJinhong LiJinhong LiJinhong LiYufang ZhouLin ChenShanggui DengBin ZhengYufeng ChenYufeng ChenYufeng ChenFrontiers Media S.A.articleshrimp peptidesdextran sulfate sodium (DSS)ulcerative colitisinflammatory bowel diseaseintestinal floraNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	shrimp peptides dextran sulfate sodium (DSS) ulcerative colitis inflammatory bowel disease intestinal flora Nutrition. Foods and food supply TX341-641
spellingShingle	shrimp peptides dextran sulfate sodium (DSS) ulcerative colitis inflammatory bowel disease intestinal flora Nutrition. Foods and food supply TX341-641 Xingwei Xiang Xingwei Xiang Xingwei Xiang Qihong Jiang Qihong Jiang Qihong Jiang Wan Shao Jinhong Li Jinhong Li Jinhong Li Yufang Zhou Lin Chen Shanggui Deng Bin Zheng Yufeng Chen Yufeng Chen Yufeng Chen Protective Effects of Shrimp Peptide on Dextran Sulfate Sodium-Induced Colitis in Mice
description	Inflammatory bowel disease, an intestinal relapsing inflammatory disease, not only impairs gastrointestinal function but also increases the chances of developing colon cancer. Currently, the effects of shrimp peptide (SP) in mice model of ulcerative colitis (UC) are still unclear. In particular, it is uncertain whether SP affects the gut flora with UC mice. In this study, we investigated the anti-inflammatory effects of SP on a dextran sulfate sodium (DSS)-induced mouse model of UC. Firstly, the molecular weight of SP was mainly distributed in the range of 180–1,000 Da (61.95% proportion), and the amino acid composition showed that SP contained 17 amino acids, of which, the essential amino acids accounted for 54.50%. In vivo, oral SP significantly attenuated the severity of colitis, such as diarrhea, weight loss, and rectal bleeding. Furthermore, treatment with SP remarkably ameliorated intestinal barrier integrity, thus lowering the levels of the inflammatory cytokines and ameliorating antioxidant indices and intestinal injury indicators in the serum and colon. Lastly, the cecal contents were used to sequence and analyze the 16S rRNA genes of bacteria. Results suggested that treatment with SP could restore the balance of intestinal flora in modeled mice by regulating the abundance of pathogenic and beneficial bacteria. Furthermore, SP could significantly improve intestinal flora dysfunction in mice with UC. In summary, our findings show that SP has a prophylactic and therapeutic effect in UC in vivo, thereby highlighting its broad medicinal applications.
format	article
author	Xingwei Xiang Xingwei Xiang Xingwei Xiang Qihong Jiang Qihong Jiang Qihong Jiang Wan Shao Jinhong Li Jinhong Li Jinhong Li Yufang Zhou Lin Chen Shanggui Deng Bin Zheng Yufeng Chen Yufeng Chen Yufeng Chen
author_facet	Xingwei Xiang Xingwei Xiang Xingwei Xiang Qihong Jiang Qihong Jiang Qihong Jiang Wan Shao Jinhong Li Jinhong Li Jinhong Li Yufang Zhou Lin Chen Shanggui Deng Bin Zheng Yufeng Chen Yufeng Chen Yufeng Chen
author_sort	Xingwei Xiang
title	Protective Effects of Shrimp Peptide on Dextran Sulfate Sodium-Induced Colitis in Mice
title_short	Protective Effects of Shrimp Peptide on Dextran Sulfate Sodium-Induced Colitis in Mice
title_full	Protective Effects of Shrimp Peptide on Dextran Sulfate Sodium-Induced Colitis in Mice
title_fullStr	Protective Effects of Shrimp Peptide on Dextran Sulfate Sodium-Induced Colitis in Mice
title_full_unstemmed	Protective Effects of Shrimp Peptide on Dextran Sulfate Sodium-Induced Colitis in Mice
title_sort	protective effects of shrimp peptide on dextran sulfate sodium-induced colitis in mice
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6608862f829b4fe98e6dd05b3a4c7550
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Protective Effects of Shrimp Peptide on Dextran Sulfate Sodium-Induced Colitis in Mice

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