Serum Zinc and Selenium Concentrations in Patients with Hypertrophy and Remodelling of the Left Ventricle Secondary to Arterial Hypertension

The aim of the study was to assess the relationship between serum selenium and zinc concentrations (Se-S and Zn-S) and the left ventricle geometry in patients suffering from arterial hypertension. A total of 78 people with arterial hypertension (mean age: 53.72 ± 12.74 years) participated in the stu...

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Autores principales:	Paweł Gać, Karolina Czerwińska, Małgorzata Poręba, Adam Prokopowicz, Helena Martynowicz, Grzegorz Mazur, Rafał Poręba
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	arterial hypertension left ventricle hypertrophy serum selenium concentrations serum zinc concentration Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/6608eefebc844255a46bcf349e42da8a
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spelling	oai:doaj.org-article:6608eefebc844255a46bcf349e42da8a2021-11-25T16:28:49ZSerum Zinc and Selenium Concentrations in Patients with Hypertrophy and Remodelling of the Left Ventricle Secondary to Arterial Hypertension10.3390/antiox101118032076-3921https://doaj.org/article/6608eefebc844255a46bcf349e42da8a2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1803https://doaj.org/toc/2076-3921The aim of the study was to assess the relationship between serum selenium and zinc concentrations (Se-S and Zn-S) and the left ventricle geometry in patients suffering from arterial hypertension. A total of 78 people with arterial hypertension (mean age: 53.72 ± 12.74 years) participated in the study. Se-S and Zn-S were determined in all patients. The type of left ventricular remodelling and hypertrophy was determined by the left ventricular mass index (LVMI) and relative wall thickness (RWT) measured by echocardiography. Se-S and Zn-S in the whole group were 89.84 ± 18.75 µg/L and 0.86 ± 0.13 mg/L. Normal left ventricular geometry was found in 28.2% of patients; left ventricular hypertrophy (LVH) in 71.8%, including concentric remodelling in 28.2%, concentric hypertrophy in 29.5%, and eccentric hypertrophy in 14.1%. LVH was statistically significantly more frequent in patients with Se-S < median compared to patients with Se-S ≥ median (87.2% vs. 56.4%, <i>p</i> < 0.05), as well as in patients with Zn-S < median compared to patients with Zn-S ≥ median (83.8% vs. 60.9%, <i>p</i> < 0.05). In hypertensive patients, older age, higher LDL cholesterol, higher fasting glucose, lower Se-S, and lower Zn-S were independently associated with LVH. In conclusion, in hypertensive patients, left ventricular hypertrophy may be associated with low levels of selenium and zinc in the serum.Paweł GaćKarolina CzerwińskaMałgorzata PorębaAdam ProkopowiczHelena MartynowiczGrzegorz MazurRafał PorębaMDPI AGarticlearterial hypertensionleft ventricle hypertrophyserum selenium concentrationsserum zinc concentrationTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1803, p 1803 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	arterial hypertension left ventricle hypertrophy serum selenium concentrations serum zinc concentration Therapeutics. Pharmacology RM1-950
spellingShingle	arterial hypertension left ventricle hypertrophy serum selenium concentrations serum zinc concentration Therapeutics. Pharmacology RM1-950 Paweł Gać Karolina Czerwińska Małgorzata Poręba Adam Prokopowicz Helena Martynowicz Grzegorz Mazur Rafał Poręba Serum Zinc and Selenium Concentrations in Patients with Hypertrophy and Remodelling of the Left Ventricle Secondary to Arterial Hypertension
description	The aim of the study was to assess the relationship between serum selenium and zinc concentrations (Se-S and Zn-S) and the left ventricle geometry in patients suffering from arterial hypertension. A total of 78 people with arterial hypertension (mean age: 53.72 ± 12.74 years) participated in the study. Se-S and Zn-S were determined in all patients. The type of left ventricular remodelling and hypertrophy was determined by the left ventricular mass index (LVMI) and relative wall thickness (RWT) measured by echocardiography. Se-S and Zn-S in the whole group were 89.84 ± 18.75 µg/L and 0.86 ± 0.13 mg/L. Normal left ventricular geometry was found in 28.2% of patients; left ventricular hypertrophy (LVH) in 71.8%, including concentric remodelling in 28.2%, concentric hypertrophy in 29.5%, and eccentric hypertrophy in 14.1%. LVH was statistically significantly more frequent in patients with Se-S < median compared to patients with Se-S ≥ median (87.2% vs. 56.4%, <i>p</i> < 0.05), as well as in patients with Zn-S < median compared to patients with Zn-S ≥ median (83.8% vs. 60.9%, <i>p</i> < 0.05). In hypertensive patients, older age, higher LDL cholesterol, higher fasting glucose, lower Se-S, and lower Zn-S were independently associated with LVH. In conclusion, in hypertensive patients, left ventricular hypertrophy may be associated with low levels of selenium and zinc in the serum.
format	article
author	Paweł Gać Karolina Czerwińska Małgorzata Poręba Adam Prokopowicz Helena Martynowicz Grzegorz Mazur Rafał Poręba
author_facet	Paweł Gać Karolina Czerwińska Małgorzata Poręba Adam Prokopowicz Helena Martynowicz Grzegorz Mazur Rafał Poręba
author_sort	Paweł Gać
title	Serum Zinc and Selenium Concentrations in Patients with Hypertrophy and Remodelling of the Left Ventricle Secondary to Arterial Hypertension
title_short	Serum Zinc and Selenium Concentrations in Patients with Hypertrophy and Remodelling of the Left Ventricle Secondary to Arterial Hypertension
title_full	Serum Zinc and Selenium Concentrations in Patients with Hypertrophy and Remodelling of the Left Ventricle Secondary to Arterial Hypertension
title_fullStr	Serum Zinc and Selenium Concentrations in Patients with Hypertrophy and Remodelling of the Left Ventricle Secondary to Arterial Hypertension
title_full_unstemmed	Serum Zinc and Selenium Concentrations in Patients with Hypertrophy and Remodelling of the Left Ventricle Secondary to Arterial Hypertension
title_sort	serum zinc and selenium concentrations in patients with hypertrophy and remodelling of the left ventricle secondary to arterial hypertension
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6608eefebc844255a46bcf349e42da8a
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Serum Zinc and Selenium Concentrations in Patients with Hypertrophy and Remodelling of the Left Ventricle Secondary to Arterial Hypertension

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