α-Glucosidase Inhibitory and A Leptospermone Derivative from <i>Rhodomyrtus tomentosa</i>

One of the treatments for diabetes mellitus disease is to control blood sugar level using an inhibitor of α-glucosidase enzyme. The methanol extracts of the fruit, stem, and leaves of Rhodomyrtus tomentosa were found significant in inhibiting α-glucosidase with an IC50 value of 20.57, 20.36 and 43.9...

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Autores principales:	Ferlinahayati Ferlinahayati, Daniel Alfarado, Eliza Eliza, Budi Untari
Formato:	article
Lenguaje:	EN
Publicado:	Department of Chemistry, Universitas Gadjah Mada 2020
Materias:	α-glucosidase rhodomyrtus tomentosa antidiabetic rhodomyrtosone d ethyl acetate fraction Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/66095d076ad7438eb02d0e128ccd9e2e
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spelling	oai:doaj.org-article:66095d076ad7438eb02d0e128ccd9e2e2021-12-02T13:16:24Zα-Glucosidase Inhibitory and A Leptospermone Derivative from <i>Rhodomyrtus tomentosa</i>1411-94202460-157810.22146/ijc.40990https://doaj.org/article/66095d076ad7438eb02d0e128ccd9e2e2020-03-01T00:00:00Zhttps://jurnal.ugm.ac.id/ijc/article/view/40990https://doaj.org/toc/1411-9420https://doaj.org/toc/2460-1578One of the treatments for diabetes mellitus disease is to control blood sugar level using an inhibitor of α-glucosidase enzyme. The methanol extracts of the fruit, stem, and leaves of Rhodomyrtus tomentosa were found significant in inhibiting α-glucosidase with an IC50 value of 20.57, 20.36 and 43.99 μg/mL respectively. The ethyl acetate and n-butanol fractions from the methanol extract of R. tomentosa fruit exhibited the potent inhibition (IC50 13.49 and 19.29 μg/mL) compare to acarbose and n-hexane fraction (IC50 383.68 and 1175.16 μg/mL). A leptospermone derivative, rhodomyrtosone D, was isolated from the ethyl acetate fraction of R. tomentosa fruit. The structure of rhodomyrtosone D was identified based on spectroscopic analysis, as well as comparing with literature data. The α-glucosidase inhibition of rhodomyrtosone D (IC50 110.45 μg/mL) was 3.5 fold more potent than acarbose. Thus, R. tomentosa plant could be potential as a natural resource of α-glucosidase inhibitor.Ferlinahayati FerlinahayatiDaniel AlfaradoEliza ElizaBudi UntariDepartment of Chemistry, Universitas Gadjah Madaarticleα-glucosidaserhodomyrtus tomentosaantidiabeticrhodomyrtosone dethyl acetate fractionChemistryQD1-999ENIndonesian Journal of Chemistry, Vol 20, Iss 2, Pp 307-313 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	α-glucosidase rhodomyrtus tomentosa antidiabetic rhodomyrtosone d ethyl acetate fraction Chemistry QD1-999
spellingShingle	α-glucosidase rhodomyrtus tomentosa antidiabetic rhodomyrtosone d ethyl acetate fraction Chemistry QD1-999 Ferlinahayati Ferlinahayati Daniel Alfarado Eliza Eliza Budi Untari α-Glucosidase Inhibitory and A Leptospermone Derivative from <i>Rhodomyrtus tomentosa</i>
description	One of the treatments for diabetes mellitus disease is to control blood sugar level using an inhibitor of α-glucosidase enzyme. The methanol extracts of the fruit, stem, and leaves of Rhodomyrtus tomentosa were found significant in inhibiting α-glucosidase with an IC50 value of 20.57, 20.36 and 43.99 μg/mL respectively. The ethyl acetate and n-butanol fractions from the methanol extract of R. tomentosa fruit exhibited the potent inhibition (IC50 13.49 and 19.29 μg/mL) compare to acarbose and n-hexane fraction (IC50 383.68 and 1175.16 μg/mL). A leptospermone derivative, rhodomyrtosone D, was isolated from the ethyl acetate fraction of R. tomentosa fruit. The structure of rhodomyrtosone D was identified based on spectroscopic analysis, as well as comparing with literature data. The α-glucosidase inhibition of rhodomyrtosone D (IC50 110.45 μg/mL) was 3.5 fold more potent than acarbose. Thus, R. tomentosa plant could be potential as a natural resource of α-glucosidase inhibitor.
format	article
author	Ferlinahayati Ferlinahayati Daniel Alfarado Eliza Eliza Budi Untari
author_facet	Ferlinahayati Ferlinahayati Daniel Alfarado Eliza Eliza Budi Untari
author_sort	Ferlinahayati Ferlinahayati
title	α-Glucosidase Inhibitory and A Leptospermone Derivative from <i>Rhodomyrtus tomentosa</i>
title_short	α-Glucosidase Inhibitory and A Leptospermone Derivative from <i>Rhodomyrtus tomentosa</i>
title_full	α-Glucosidase Inhibitory and A Leptospermone Derivative from <i>Rhodomyrtus tomentosa</i>
title_fullStr	α-Glucosidase Inhibitory and A Leptospermone Derivative from <i>Rhodomyrtus tomentosa</i>
title_full_unstemmed	α-Glucosidase Inhibitory and A Leptospermone Derivative from <i>Rhodomyrtus tomentosa</i>
title_sort	α-glucosidase inhibitory and a leptospermone derivative from <i>rhodomyrtus tomentosa</i>
publisher	Department of Chemistry, Universitas Gadjah Mada
publishDate	2020
url	https://doaj.org/article/66095d076ad7438eb02d0e128ccd9e2e
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α-Glucosidase Inhibitory and A Leptospermone Derivative from <i>Rhodomyrtus tomentosa</i>

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