Transient-axial-chirality controlled asymmetric rhodium-carbene C(sp2)-H functionalization for the synthesis of chiral fluorenes

The formation of chiral molecules generally relies on direct chirality transfer from catalyst to products. Here, the authors report a strategy based on point chirality transfer from the catalyst to a dirhodium carbene intermediate with axial chirality, which is then transferred to products via C(sp2...

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Autores principales:	Kuiyong Dong, Xing Fan, Chao Pei, Yang Zheng, Sailan Chang, Ju Cai, Lihua Qiu, Zhi-Xiang Yu, Xinfang Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6609708ced464bc581ae42daa272f2d5
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spelling	oai:doaj.org-article:6609708ced464bc581ae42daa272f2d52021-12-02T16:50:20ZTransient-axial-chirality controlled asymmetric rhodium-carbene C(sp2)-H functionalization for the synthesis of chiral fluorenes10.1038/s41467-020-16098-82041-1723https://doaj.org/article/6609708ced464bc581ae42daa272f2d52020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16098-8https://doaj.org/toc/2041-1723The formation of chiral molecules generally relies on direct chirality transfer from catalyst to products. Here, the authors report a strategy based on point chirality transfer from the catalyst to a dirhodium carbene intermediate with axial chirality, which is then transferred to products via C(sp2)-H functionalization.Kuiyong DongXing FanChao PeiYang ZhengSailan ChangJu CaiLihua QiuZhi-Xiang YuXinfang XuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kuiyong Dong Xing Fan Chao Pei Yang Zheng Sailan Chang Ju Cai Lihua Qiu Zhi-Xiang Yu Xinfang Xu Transient-axial-chirality controlled asymmetric rhodium-carbene C(sp2)-H functionalization for the synthesis of chiral fluorenes
description	The formation of chiral molecules generally relies on direct chirality transfer from catalyst to products. Here, the authors report a strategy based on point chirality transfer from the catalyst to a dirhodium carbene intermediate with axial chirality, which is then transferred to products via C(sp2)-H functionalization.
format	article
author	Kuiyong Dong Xing Fan Chao Pei Yang Zheng Sailan Chang Ju Cai Lihua Qiu Zhi-Xiang Yu Xinfang Xu
author_facet	Kuiyong Dong Xing Fan Chao Pei Yang Zheng Sailan Chang Ju Cai Lihua Qiu Zhi-Xiang Yu Xinfang Xu
author_sort	Kuiyong Dong
title	Transient-axial-chirality controlled asymmetric rhodium-carbene C(sp2)-H functionalization for the synthesis of chiral fluorenes
title_short	Transient-axial-chirality controlled asymmetric rhodium-carbene C(sp2)-H functionalization for the synthesis of chiral fluorenes
title_full	Transient-axial-chirality controlled asymmetric rhodium-carbene C(sp2)-H functionalization for the synthesis of chiral fluorenes
title_fullStr	Transient-axial-chirality controlled asymmetric rhodium-carbene C(sp2)-H functionalization for the synthesis of chiral fluorenes
title_full_unstemmed	Transient-axial-chirality controlled asymmetric rhodium-carbene C(sp2)-H functionalization for the synthesis of chiral fluorenes
title_sort	transient-axial-chirality controlled asymmetric rhodium-carbene c(sp2)-h functionalization for the synthesis of chiral fluorenes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6609708ced464bc581ae42daa272f2d5
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_version_	1718383042575204352

Transient-axial-chirality controlled asymmetric rhodium-carbene C(sp2)-H functionalization for the synthesis of chiral fluorenes

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