Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4

Melanoma cells can switch between proliferative and invasive phenotypes. Here the authors show that the embryonic stem cell factor Sall4 is a negative regulator of melanoma phenotype switching where its loss leads to the acquisition of an invasive phenotype, due to derepression of invasiveness genes...

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Autores principales:	Johanna Diener, Arianna Baggiolini, Mattias Pernebrink, Damian Dalcher, Luigi Lerra, Phil F. Cheng, Sandra Varum, Jessica Häusel, Salome Stierli, Mathias Treier, Lorenz Studer, Konrad Basler, Mitchell P. Levesque, Reinhard Dummer, Raffaella Santoro, Claudio Cantù, Lukas Sommer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/660bf2af02d44967be0835d0819d4414
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spelling	oai:doaj.org-article:660bf2af02d44967be0835d0819d44142021-12-02T16:45:42ZEpigenetic control of melanoma cell invasiveness by the stem cell factor SALL410.1038/s41467-021-25326-82041-1723https://doaj.org/article/660bf2af02d44967be0835d0819d44142021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25326-8https://doaj.org/toc/2041-1723Melanoma cells can switch between proliferative and invasive phenotypes. Here the authors show that the embryonic stem cell factor Sall4 is a negative regulator of melanoma phenotype switching where its loss leads to the acquisition of an invasive phenotype, due to derepression of invasiveness genes.Johanna DienerArianna BaggioliniMattias PernebrinkDamian DalcherLuigi LerraPhil F. ChengSandra VarumJessica HäuselSalome StierliMathias TreierLorenz StuderKonrad BaslerMitchell P. LevesqueReinhard DummerRaffaella SantoroClaudio CantùLukas SommerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Johanna Diener Arianna Baggiolini Mattias Pernebrink Damian Dalcher Luigi Lerra Phil F. Cheng Sandra Varum Jessica Häusel Salome Stierli Mathias Treier Lorenz Studer Konrad Basler Mitchell P. Levesque Reinhard Dummer Raffaella Santoro Claudio Cantù Lukas Sommer Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4
description	Melanoma cells can switch between proliferative and invasive phenotypes. Here the authors show that the embryonic stem cell factor Sall4 is a negative regulator of melanoma phenotype switching where its loss leads to the acquisition of an invasive phenotype, due to derepression of invasiveness genes.
format	article
author	Johanna Diener Arianna Baggiolini Mattias Pernebrink Damian Dalcher Luigi Lerra Phil F. Cheng Sandra Varum Jessica Häusel Salome Stierli Mathias Treier Lorenz Studer Konrad Basler Mitchell P. Levesque Reinhard Dummer Raffaella Santoro Claudio Cantù Lukas Sommer
author_facet	Johanna Diener Arianna Baggiolini Mattias Pernebrink Damian Dalcher Luigi Lerra Phil F. Cheng Sandra Varum Jessica Häusel Salome Stierli Mathias Treier Lorenz Studer Konrad Basler Mitchell P. Levesque Reinhard Dummer Raffaella Santoro Claudio Cantù Lukas Sommer
author_sort	Johanna Diener
title	Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4
title_short	Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4
title_full	Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4
title_fullStr	Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4
title_full_unstemmed	Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4
title_sort	epigenetic control of melanoma cell invasiveness by the stem cell factor sall4
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/660bf2af02d44967be0835d0819d4414
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Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4

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