A primitive type of renin-expressing lymphocyte protects the organism against infections

Abstract The hormone renin plays a crucial role in the regulation of blood pressure and fluid-electrolyte homeostasis. Normally, renin is synthesized by juxtaglomerular (JG) cells, a specialized group of myoepithelial cells located near the entrance to the kidney glomeruli. In response to low blood...

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Autores principales:	Brian C. Belyea, Araceli E. Santiago, Wilson A. Vasconez, Vidya K. Nagalakshmi, Fang Xu, Theodore C. Mehalic, Maria Luisa S. Sequeira-Lopez, R. Ariel Gomez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/660db11b5d0e49efb6c0e8f6c7c6430b
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spelling	oai:doaj.org-article:660db11b5d0e49efb6c0e8f6c7c6430b2021-12-02T14:25:09ZA primitive type of renin-expressing lymphocyte protects the organism against infections10.1038/s41598-021-86629-w2045-2322https://doaj.org/article/660db11b5d0e49efb6c0e8f6c7c6430b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86629-whttps://doaj.org/toc/2045-2322Abstract The hormone renin plays a crucial role in the regulation of blood pressure and fluid-electrolyte homeostasis. Normally, renin is synthesized by juxtaglomerular (JG) cells, a specialized group of myoepithelial cells located near the entrance to the kidney glomeruli. In response to low blood pressure and/or a decrease in extracellular fluid volume (as it occurs during dehydration, hypotension, or septic shock) JG cells respond by releasing renin to the circulation to reestablish homeostasis. Interestingly, renin-expressing cells also exist outside of the kidney, where their function has remained a mystery. We discovered a unique type of renin-expressing B-1 lymphocyte that may have unrecognized roles in defending the organism against infections. These cells synthesize renin, entrap and phagocyte bacteria and control bacterial growth. The ability of renin-bearing lymphocytes to control infections—which is enhanced by the presence of renin—adds a novel, previously unsuspected dimension to the defense role of renin-expressing cells, linking the endocrine control of circulatory homeostasis with the immune control of infections to ensure survival.Brian C. BelyeaAraceli E. SantiagoWilson A. VasconezVidya K. NagalakshmiFang XuTheodore C. MehalicMaria Luisa S. Sequeira-LopezR. Ariel GomezNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Brian C. Belyea Araceli E. Santiago Wilson A. Vasconez Vidya K. Nagalakshmi Fang Xu Theodore C. Mehalic Maria Luisa S. Sequeira-Lopez R. Ariel Gomez A primitive type of renin-expressing lymphocyte protects the organism against infections
description	Abstract The hormone renin plays a crucial role in the regulation of blood pressure and fluid-electrolyte homeostasis. Normally, renin is synthesized by juxtaglomerular (JG) cells, a specialized group of myoepithelial cells located near the entrance to the kidney glomeruli. In response to low blood pressure and/or a decrease in extracellular fluid volume (as it occurs during dehydration, hypotension, or septic shock) JG cells respond by releasing renin to the circulation to reestablish homeostasis. Interestingly, renin-expressing cells also exist outside of the kidney, where their function has remained a mystery. We discovered a unique type of renin-expressing B-1 lymphocyte that may have unrecognized roles in defending the organism against infections. These cells synthesize renin, entrap and phagocyte bacteria and control bacterial growth. The ability of renin-bearing lymphocytes to control infections—which is enhanced by the presence of renin—adds a novel, previously unsuspected dimension to the defense role of renin-expressing cells, linking the endocrine control of circulatory homeostasis with the immune control of infections to ensure survival.
format	article
author	Brian C. Belyea Araceli E. Santiago Wilson A. Vasconez Vidya K. Nagalakshmi Fang Xu Theodore C. Mehalic Maria Luisa S. Sequeira-Lopez R. Ariel Gomez
author_facet	Brian C. Belyea Araceli E. Santiago Wilson A. Vasconez Vidya K. Nagalakshmi Fang Xu Theodore C. Mehalic Maria Luisa S. Sequeira-Lopez R. Ariel Gomez
author_sort	Brian C. Belyea
title	A primitive type of renin-expressing lymphocyte protects the organism against infections
title_short	A primitive type of renin-expressing lymphocyte protects the organism against infections
title_full	A primitive type of renin-expressing lymphocyte protects the organism against infections
title_fullStr	A primitive type of renin-expressing lymphocyte protects the organism against infections
title_full_unstemmed	A primitive type of renin-expressing lymphocyte protects the organism against infections
title_sort	primitive type of renin-expressing lymphocyte protects the organism against infections
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/660db11b5d0e49efb6c0e8f6c7c6430b
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A primitive type of renin-expressing lymphocyte protects the organism against infections

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