Genomic signatures of adaptive introgression from European mouflon into domestic sheep

Abstract Mouflon (Ovis aries musimon) became extinct from mainland Europe after the Neolithic, but remnant populations from the Mediterranean islands of Corsica and Sardinia have been used for reintroductions across Europe since the 19th-century. Mouflon x sheep hybrids are larger-bodied than mouflo...

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Autores principales:	Mario Barbato, Frank Hailer, Pablo Orozco-terWengel, James Kijas, Paolo Mereu, Pierangela Cabras, Raffaele Mazza, Monica Pirastru, Michael W. Bruford
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/660e69713ba2413c85549225fb881327
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spelling	oai:doaj.org-article:660e69713ba2413c85549225fb8813272021-12-02T12:30:27ZGenomic signatures of adaptive introgression from European mouflon into domestic sheep10.1038/s41598-017-07382-72045-2322https://doaj.org/article/660e69713ba2413c85549225fb8813272017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07382-7https://doaj.org/toc/2045-2322Abstract Mouflon (Ovis aries musimon) became extinct from mainland Europe after the Neolithic, but remnant populations from the Mediterranean islands of Corsica and Sardinia have been used for reintroductions across Europe since the 19th-century. Mouflon x sheep hybrids are larger-bodied than mouflon, potentially showing increased male reproductive success, but little is known about genomic levels of admixture, or about the adaptive significance of introgression between resident mouflon and local sheep breeds. Here we analysed Ovine medium-density SNP array genotypes of 92 mouflon from six geographic regions, along with data from 330 individuals of 16 domestic sheep breeds. We found lower levels of genetic diversity in mouflon than in domestic sheep, consistent with past bottlenecks in mouflon. Introgression signals were bidirectional and affected most mouflon and sheep populations, being strongest in one Sardinian mouflon population. Developing and using a novel approach to identify chromosomal regions with consistent introgression signals, we infer adaptive introgression from mouflon to domestic sheep related to immunity mechanisms, but not in the opposite direction. Further, we infer that Soay and Sarda sheep carry introgressed mouflon alleles involved in bitter taste perception and/or innate immunity. Our results illustrate the potential for adaptive introgression even among recently diverged populations.Mario BarbatoFrank HailerPablo Orozco-terWengelJames KijasPaolo MereuPierangela CabrasRaffaele MazzaMonica PirastruMichael W. BrufordNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mario Barbato Frank Hailer Pablo Orozco-terWengel James Kijas Paolo Mereu Pierangela Cabras Raffaele Mazza Monica Pirastru Michael W. Bruford Genomic signatures of adaptive introgression from European mouflon into domestic sheep
description	Abstract Mouflon (Ovis aries musimon) became extinct from mainland Europe after the Neolithic, but remnant populations from the Mediterranean islands of Corsica and Sardinia have been used for reintroductions across Europe since the 19th-century. Mouflon x sheep hybrids are larger-bodied than mouflon, potentially showing increased male reproductive success, but little is known about genomic levels of admixture, or about the adaptive significance of introgression between resident mouflon and local sheep breeds. Here we analysed Ovine medium-density SNP array genotypes of 92 mouflon from six geographic regions, along with data from 330 individuals of 16 domestic sheep breeds. We found lower levels of genetic diversity in mouflon than in domestic sheep, consistent with past bottlenecks in mouflon. Introgression signals were bidirectional and affected most mouflon and sheep populations, being strongest in one Sardinian mouflon population. Developing and using a novel approach to identify chromosomal regions with consistent introgression signals, we infer adaptive introgression from mouflon to domestic sheep related to immunity mechanisms, but not in the opposite direction. Further, we infer that Soay and Sarda sheep carry introgressed mouflon alleles involved in bitter taste perception and/or innate immunity. Our results illustrate the potential for adaptive introgression even among recently diverged populations.
format	article
author	Mario Barbato Frank Hailer Pablo Orozco-terWengel James Kijas Paolo Mereu Pierangela Cabras Raffaele Mazza Monica Pirastru Michael W. Bruford
author_facet	Mario Barbato Frank Hailer Pablo Orozco-terWengel James Kijas Paolo Mereu Pierangela Cabras Raffaele Mazza Monica Pirastru Michael W. Bruford
author_sort	Mario Barbato
title	Genomic signatures of adaptive introgression from European mouflon into domestic sheep
title_short	Genomic signatures of adaptive introgression from European mouflon into domestic sheep
title_full	Genomic signatures of adaptive introgression from European mouflon into domestic sheep
title_fullStr	Genomic signatures of adaptive introgression from European mouflon into domestic sheep
title_full_unstemmed	Genomic signatures of adaptive introgression from European mouflon into domestic sheep
title_sort	genomic signatures of adaptive introgression from european mouflon into domestic sheep
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/660e69713ba2413c85549225fb881327
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Genomic signatures of adaptive introgression from European mouflon into domestic sheep

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