Does the Intraluminal Thrombus Provoke the Rupture of the Abdominal Aortic Aneurysm Wall?

The role of intraluminal thrombus (ILT) in the rupture of abdominal aortic aneurysms (AAA) is controversial, and it is unclear whether it increases or decreases the risk of rupture. This research aims to find a clear answer to this question. Previous computer modelling suggests that an ILT lowers ox...

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Autor principal:	Mohammed Almijalli
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	human aorta abdominal aortic aneurysm intraluminal thrombus computational fluid dynamics 3D reconstruction Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/660fdfe119ff4e0f92167b2b61080a55
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spelling	oai:doaj.org-article:660fdfe119ff4e0f92167b2b61080a552021-11-11T15:02:09ZDoes the Intraluminal Thrombus Provoke the Rupture of the Abdominal Aortic Aneurysm Wall?10.3390/app112199412076-3417https://doaj.org/article/660fdfe119ff4e0f92167b2b61080a552021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/21/9941https://doaj.org/toc/2076-3417The role of intraluminal thrombus (ILT) in the rupture of abdominal aortic aneurysms (AAA) is controversial, and it is unclear whether it increases or decreases the risk of rupture. This research aims to find a clear answer to this question. Previous computer modelling suggests that an ILT lowers oxygen dissemination to the AAA wall, contributing to wall thinning. The methodology used in this study determines the amount of oxygen reaching the aneurysm wall after passing through the ILT by using the porous nature of the ILT to recreate the condition as closely as feasible. Using computed tomographic images, patient-specific three-dimensional (3D) AAA geometries were recreated. Modelling blood and oxygen flow in AAA was obtained using a computational fluid dynamics (CFD) approach. Our findings indicated that the oxygen volume percentage had completely reached the aneurysm wall. Only at the inlet and outflow did the greatest wall shear stress (WSS) occur, with a significant drop in the central region of the aneurysm wall. CFD was used to calculate the velocity, pressure, and WSS of aortic blood flow. ILT had no effect on oxygen flow to the aneurysm wall, disproving the theory that it produces local hypoxia.Mohammed AlmijalliMDPI AGarticlehuman aortaabdominal aortic aneurysmintraluminal thrombuscomputational fluid dynamics3D reconstructionTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 9941, p 9941 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	human aorta abdominal aortic aneurysm intraluminal thrombus computational fluid dynamics 3D reconstruction Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	human aorta abdominal aortic aneurysm intraluminal thrombus computational fluid dynamics 3D reconstruction Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Mohammed Almijalli Does the Intraluminal Thrombus Provoke the Rupture of the Abdominal Aortic Aneurysm Wall?
description	The role of intraluminal thrombus (ILT) in the rupture of abdominal aortic aneurysms (AAA) is controversial, and it is unclear whether it increases or decreases the risk of rupture. This research aims to find a clear answer to this question. Previous computer modelling suggests that an ILT lowers oxygen dissemination to the AAA wall, contributing to wall thinning. The methodology used in this study determines the amount of oxygen reaching the aneurysm wall after passing through the ILT by using the porous nature of the ILT to recreate the condition as closely as feasible. Using computed tomographic images, patient-specific three-dimensional (3D) AAA geometries were recreated. Modelling blood and oxygen flow in AAA was obtained using a computational fluid dynamics (CFD) approach. Our findings indicated that the oxygen volume percentage had completely reached the aneurysm wall. Only at the inlet and outflow did the greatest wall shear stress (WSS) occur, with a significant drop in the central region of the aneurysm wall. CFD was used to calculate the velocity, pressure, and WSS of aortic blood flow. ILT had no effect on oxygen flow to the aneurysm wall, disproving the theory that it produces local hypoxia.
format	article
author	Mohammed Almijalli
author_facet	Mohammed Almijalli
author_sort	Mohammed Almijalli
title	Does the Intraluminal Thrombus Provoke the Rupture of the Abdominal Aortic Aneurysm Wall?
title_short	Does the Intraluminal Thrombus Provoke the Rupture of the Abdominal Aortic Aneurysm Wall?
title_full	Does the Intraluminal Thrombus Provoke the Rupture of the Abdominal Aortic Aneurysm Wall?
title_fullStr	Does the Intraluminal Thrombus Provoke the Rupture of the Abdominal Aortic Aneurysm Wall?
title_full_unstemmed	Does the Intraluminal Thrombus Provoke the Rupture of the Abdominal Aortic Aneurysm Wall?
title_sort	does the intraluminal thrombus provoke the rupture of the abdominal aortic aneurysm wall?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/660fdfe119ff4e0f92167b2b61080a55
work_keys_str_mv	AT mohammedalmijalli doestheintraluminalthrombusprovoketheruptureoftheabdominalaorticaneurysmwall
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Does the Intraluminal Thrombus Provoke the Rupture of the Abdominal Aortic Aneurysm Wall?

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