Carbon-covered magnetic nanomaterials and their application for the thermolysis of cancer cells

Yang Xu1, Meena Mahmood1, Ashley Fejleh1, Zhongrui Li1, Fumiya Watanabe1, Steve Trigwell2, Reginald B Little3, Vasyl P Kunets4, Enkeleda Dervishi1, Alexandru R Biris5, Gregory J Salamo4, Alexandru S Biris11Nanotechnology Center and Applied Science Department, University of Arkansas at Little Rock, L...

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Autores principales:	Yang Xu, Meena Mahmood, Ashley Fejleh, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6612b25ebb72488ea119f56e388c650a
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spelling	oai:doaj.org-article:6612b25ebb72488ea119f56e388c650a2021-12-02T02:42:06ZCarbon-covered magnetic nanomaterials and their application for the thermolysis of cancer cells1176-91141178-2013https://doaj.org/article/6612b25ebb72488ea119f56e388c650a2010-03-01T00:00:00Zhttp://www.dovepress.com/carbon-covered-magnetic-nanomaterials-and-their-application-for-the-th-a4067https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Yang Xu1, Meena Mahmood1, Ashley Fejleh1, Zhongrui Li1, Fumiya Watanabe1, Steve Trigwell2, Reginald B Little3, Vasyl P Kunets4, Enkeleda Dervishi1, Alexandru R Biris5, Gregory J Salamo4, Alexandru S Biris11Nanotechnology Center and Applied Science Department, University of Arkansas at Little Rock, Little Rock, AR, USA; 2Applied Science and Technology, ASRC Aerospace, NASA Kennedy Space Center, FL, USA; 3Department of Chemistry, Elizabeth City State University, Elizabeth City, NC, USA; 4Physics Department, University of Arkansas, Fayetteville, AR, USA; 5National Institute for Research and Development of Isotopic and Molecular Technologies, Cluj Napoca, RomaniaAbstract: Three types of graphitic shelled-magnetic core (Fe, Fe/Co, and Co) nanoparticles (named as C-Fe, C-Fe/Co, and C-Co NPs) were synthesized by radio frequency-catalytic chemical vapor deposition (RF-cCVD). X-ray diffraction and X-ray photoelectron spectroscopy analysis revealed that the cores inside the carbon shells of these NPs were preserved in their metallic states. Fluorescence microscopy images indicated effective penetrations of the NPs through the cellular membranes of cultured cancer HeLa cells, both inside the cytoplasm and the nucleus. Low RF radiation of 350 kHz induced localized heating of the magnetic NPs, which triggered cell death. Apoptosis inducement was found to be dependent on the RF irradiation time and NP concentration. It was showed that the Fe-C NPs had a much higher ability of killing the cancer cells (over 99%) compared with the other types of NPs (C-Co or C-Fe/Co), even at a very low concentration of 0.83 &mu;g/mL. The localized heating of NPs inside the cancer cells comes from the hysteresis heating and resistive heating through eddy currents generated under the RF radiation. The RF thermal ablation properties of the magnetic NPs were correlated with the analysis provided by a superconducting quantum interference device (SQUID).Keywords: graphitic shelled, magnetic nanoparticles, radio frequency, thermal ablation, HeLa cells Yang XuMeena MahmoodAshley Fejlehet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 167-176 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Yang Xu Meena Mahmood Ashley Fejleh et al Carbon-covered magnetic nanomaterials and their application for the thermolysis of cancer cells
description	Yang Xu1, Meena Mahmood1, Ashley Fejleh1, Zhongrui Li1, Fumiya Watanabe1, Steve Trigwell2, Reginald B Little3, Vasyl P Kunets4, Enkeleda Dervishi1, Alexandru R Biris5, Gregory J Salamo4, Alexandru S Biris11Nanotechnology Center and Applied Science Department, University of Arkansas at Little Rock, Little Rock, AR, USA; 2Applied Science and Technology, ASRC Aerospace, NASA Kennedy Space Center, FL, USA; 3Department of Chemistry, Elizabeth City State University, Elizabeth City, NC, USA; 4Physics Department, University of Arkansas, Fayetteville, AR, USA; 5National Institute for Research and Development of Isotopic and Molecular Technologies, Cluj Napoca, RomaniaAbstract: Three types of graphitic shelled-magnetic core (Fe, Fe/Co, and Co) nanoparticles (named as C-Fe, C-Fe/Co, and C-Co NPs) were synthesized by radio frequency-catalytic chemical vapor deposition (RF-cCVD). X-ray diffraction and X-ray photoelectron spectroscopy analysis revealed that the cores inside the carbon shells of these NPs were preserved in their metallic states. Fluorescence microscopy images indicated effective penetrations of the NPs through the cellular membranes of cultured cancer HeLa cells, both inside the cytoplasm and the nucleus. Low RF radiation of 350 kHz induced localized heating of the magnetic NPs, which triggered cell death. Apoptosis inducement was found to be dependent on the RF irradiation time and NP concentration. It was showed that the Fe-C NPs had a much higher ability of killing the cancer cells (over 99%) compared with the other types of NPs (C-Co or C-Fe/Co), even at a very low concentration of 0.83 &mu;g/mL. The localized heating of NPs inside the cancer cells comes from the hysteresis heating and resistive heating through eddy currents generated under the RF radiation. The RF thermal ablation properties of the magnetic NPs were correlated with the analysis provided by a superconducting quantum interference device (SQUID).Keywords: graphitic shelled, magnetic nanoparticles, radio frequency, thermal ablation, HeLa cells
format	article
author	Yang Xu Meena Mahmood Ashley Fejleh et al
author_facet	Yang Xu Meena Mahmood Ashley Fejleh et al
author_sort	Yang Xu
title	Carbon-covered magnetic nanomaterials and their application for the thermolysis of cancer cells
title_short	Carbon-covered magnetic nanomaterials and their application for the thermolysis of cancer cells
title_full	Carbon-covered magnetic nanomaterials and their application for the thermolysis of cancer cells
title_fullStr	Carbon-covered magnetic nanomaterials and their application for the thermolysis of cancer cells
title_full_unstemmed	Carbon-covered magnetic nanomaterials and their application for the thermolysis of cancer cells
title_sort	carbon-covered magnetic nanomaterials and their application for the thermolysis of cancer cells
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/6612b25ebb72488ea119f56e388c650a
work_keys_str_mv	AT yangxu carboncoveredmagneticnanomaterialsandtheirapplicationforthethermolysisofcancercells AT meenamahmood carboncoveredmagneticnanomaterialsandtheirapplicationforthethermolysisofcancercells AT ashleyfejleh carboncoveredmagneticnanomaterialsandtheirapplicationforthethermolysisofcancercells AT etal carboncoveredmagneticnanomaterialsandtheirapplicationforthethermolysisofcancercells
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Carbon-covered magnetic nanomaterials and their application for the thermolysis of cancer cells

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