Fibrinogen and C-Reactive-Protein Variation in Mild and Severe Preeclampsia

BACKGROUND AND OBJECTIVE: Preeclampsia is one of the most prevalent diseases in pregnancy that include proteinuria and hypertension and can be associated with morbidity and mortality in mother and neonate. Endothelial cell dysfunction and inflammation are considered to have a crucial role in the pat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	SH Yazdani, Z Bouzari, H Majd
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2010
Materias:	preeclampsia fibrinogen crp Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6614ea37c4744cb88b394e6a7f1488bb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6614ea37c4744cb88b394e6a7f1488bb
record_format	dspace
spelling	oai:doaj.org-article:6614ea37c4744cb88b394e6a7f1488bb2021-11-10T09:00:36ZFibrinogen and C-Reactive-Protein Variation in Mild and Severe Preeclampsia1561-41072251-7170https://doaj.org/article/6614ea37c4744cb88b394e6a7f1488bb2010-10-01T00:00:00Zhttp://jbums.org/article-1-3670-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Preeclampsia is one of the most prevalent diseases in pregnancy that include proteinuria and hypertension and can be associated with morbidity and mortality in mother and neonate. Endothelial cell dysfunction and inflammation are considered to have a crucial role in the pathophysiologic mechanism of preeclampsia. A systemic inflammatory response involves both the immune system and the clotting and fibrinolytic system. The aim of this study was to determine the association of fibrinogen and C-reactive protein (CRP) with the severity of preeclampsia. METHODS: This cross-sectional study was performed on 44 normal pregnant women, 35 cases with mild preeclampsia and 19 cases with severe preeclampsia that referred to Shahid Yahyanejad hospital, Babol, Iran. All of patients were primigravida and single pregnancy, cases over the age of 15 and gestational age of 30 to 40 weeks. Patients didn receive betamethasone in last week. The diagnosis of preeclampsia is made whose blood pressure reaches 140/90 mmHg or greater with proteinuria (trace or greater in random urine samples). Blood sample were taken from all subjects to measure CRP and fibrinogen and send to single laboratory. Then the groups were compared.FINDINGS: The mean of CRP was significantly different in control (2.28±0.81) and mild preeclampsia group (4.91±5.99) (p=0.03), and there was not significant difference between control (2.28±0.81) and severe preeclampsia group (3.8±3.05). The mean of fibrinogen was not significantly different in control group (360.5±62.35) and mild preeclampsia (344.71±65.07) and severe preeclampsia groups (340.95±78.62). CONCLUSION: Results show that CRP increased in mild preeclampsia in comparison with control group but there was not significant difference between fibrinogen level in control group with mild and severe preeclampsia.SH YazdaniZ BouzariH MajdBabol University of Medical SciencesarticlepreeclampsiafibrinogencrpMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 12, Iss 4, Pp 67-71 (2010)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	preeclampsia fibrinogen crp Medicine R Medicine (General) R5-920
spellingShingle	preeclampsia fibrinogen crp Medicine R Medicine (General) R5-920 SH Yazdani Z Bouzari H Majd Fibrinogen and C-Reactive-Protein Variation in Mild and Severe Preeclampsia
description	BACKGROUND AND OBJECTIVE: Preeclampsia is one of the most prevalent diseases in pregnancy that include proteinuria and hypertension and can be associated with morbidity and mortality in mother and neonate. Endothelial cell dysfunction and inflammation are considered to have a crucial role in the pathophysiologic mechanism of preeclampsia. A systemic inflammatory response involves both the immune system and the clotting and fibrinolytic system. The aim of this study was to determine the association of fibrinogen and C-reactive protein (CRP) with the severity of preeclampsia. METHODS: This cross-sectional study was performed on 44 normal pregnant women, 35 cases with mild preeclampsia and 19 cases with severe preeclampsia that referred to Shahid Yahyanejad hospital, Babol, Iran. All of patients were primigravida and single pregnancy, cases over the age of 15 and gestational age of 30 to 40 weeks. Patients didn receive betamethasone in last week. The diagnosis of preeclampsia is made whose blood pressure reaches 140/90 mmHg or greater with proteinuria (trace or greater in random urine samples). Blood sample were taken from all subjects to measure CRP and fibrinogen and send to single laboratory. Then the groups were compared.FINDINGS: The mean of CRP was significantly different in control (2.28±0.81) and mild preeclampsia group (4.91±5.99) (p=0.03), and there was not significant difference between control (2.28±0.81) and severe preeclampsia group (3.8±3.05). The mean of fibrinogen was not significantly different in control group (360.5±62.35) and mild preeclampsia (344.71±65.07) and severe preeclampsia groups (340.95±78.62). CONCLUSION: Results show that CRP increased in mild preeclampsia in comparison with control group but there was not significant difference between fibrinogen level in control group with mild and severe preeclampsia.
format	article
author	SH Yazdani Z Bouzari H Majd
author_facet	SH Yazdani Z Bouzari H Majd
author_sort	SH Yazdani
title	Fibrinogen and C-Reactive-Protein Variation in Mild and Severe Preeclampsia
title_short	Fibrinogen and C-Reactive-Protein Variation in Mild and Severe Preeclampsia
title_full	Fibrinogen and C-Reactive-Protein Variation in Mild and Severe Preeclampsia
title_fullStr	Fibrinogen and C-Reactive-Protein Variation in Mild and Severe Preeclampsia
title_full_unstemmed	Fibrinogen and C-Reactive-Protein Variation in Mild and Severe Preeclampsia
title_sort	fibrinogen and c-reactive-protein variation in mild and severe preeclampsia
publisher	Babol University of Medical Sciences
publishDate	2010
url	https://doaj.org/article/6614ea37c4744cb88b394e6a7f1488bb
work_keys_str_mv	AT shyazdani fibrinogenandcreactiveproteinvariationinmildandseverepreeclampsia AT zbouzari fibrinogenandcreactiveproteinvariationinmildandseverepreeclampsia AT hmajd fibrinogenandcreactiveproteinvariationinmildandseverepreeclampsia
_version_	1718440291957997568

Fibrinogen and C-Reactive-Protein Variation in Mild and Severe Preeclampsia

Ejemplares similares