Age-old wisdom concerning cell-based therapies with added knowledge in the stem cell era: our perspectives

Senthilkumar Preethy,1,2 Sudhakar John,1 Jegatheesan Saravana Ganesh,1 Thangavelu Srinivasan,1 Hiroshi Terunuma,3 Masaru Iwasaki,4 Samuel J Abraham1,4 1Nichi-In Centre for Regenerative Medicine, 2Hope Foundation Trust, Chennai, India; 3Biotherapy Institute of Japan, Tokyo, 4Yamanashi University Scho...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Preethy S, John S, Ganesh JS, Srinivasan T, Terunuma H, Iwasaki M, Abraham SJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/661e6f69ac8543998991cdba17dd3ad3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:661e6f69ac8543998991cdba17dd3ad3
record_format	dspace
spelling	oai:doaj.org-article:661e6f69ac8543998991cdba17dd3ad32021-12-02T00:51:11ZAge-old wisdom concerning cell-based therapies with added knowledge in the stem cell era: our perspectives1178-6957https://doaj.org/article/661e6f69ac8543998991cdba17dd3ad32013-04-01T00:00:00Zhttp://www.dovepress.com/age-old-wisdom-concerning-cell-based-therapies-with-added-knowledge-in-a12659https://doaj.org/toc/1178-6957Senthilkumar Preethy,1,2 Sudhakar John,1 Jegatheesan Saravana Ganesh,1 Thangavelu Srinivasan,1 Hiroshi Terunuma,3 Masaru Iwasaki,4 Samuel J Abraham1,4 1Nichi-In Centre for Regenerative Medicine, 2Hope Foundation Trust, Chennai, India; 3Biotherapy Institute of Japan, Tokyo, 4Yamanashi University School of Medicine, Chuo, Japan Abstract: Among the various strategies providing a cure for illness, cell-based therapies have caught the attention of the world with the advent of the "stem cell" era. Our inherent understanding indicates that stem cells have been in existence since the birth of multicellular organisms. However, the formal discovery of stem cells in the last century, followed by their intricate and extensive analysis, has led to clinical and translational efforts with the aim of using them in the treatment of conditions which don't have a definitive therapeutic strategy, has fueled our interest and expectations. Technological advances in our ability to study their cellular components in depth, along with surface markers and other finer constituents, that were unknown until last century, have improved our understanding, leading to several novel applications. This has created a need to establish guidelines, and in that process, there are expressed understandings and views which describe cell therapy along lines similar to that of biologic products, drugs, and devices. However, the age-old wisdom of using cells as tools for curing illness should not be misled by recent knowledge, to make cell therapy using highly complex stem cells equal to factory-synthesized and reproducible chemical compounds, drugs, or devices. This article analyses the differences between these two entities from various perspectives. Keywords: cell transplantation, drugs, regenerative medicine, stem cellsPreethy SJohn SGanesh JSSrinivasan TTerunuma HIwasaki MAbraham SJDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2013, Iss default, Pp 13-18 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Preethy S John S Ganesh JS Srinivasan T Terunuma H Iwasaki M Abraham SJ Age-old wisdom concerning cell-based therapies with added knowledge in the stem cell era: our perspectives
description	Senthilkumar Preethy,1,2 Sudhakar John,1 Jegatheesan Saravana Ganesh,1 Thangavelu Srinivasan,1 Hiroshi Terunuma,3 Masaru Iwasaki,4 Samuel J Abraham1,4 1Nichi-In Centre for Regenerative Medicine, 2Hope Foundation Trust, Chennai, India; 3Biotherapy Institute of Japan, Tokyo, 4Yamanashi University School of Medicine, Chuo, Japan Abstract: Among the various strategies providing a cure for illness, cell-based therapies have caught the attention of the world with the advent of the "stem cell" era. Our inherent understanding indicates that stem cells have been in existence since the birth of multicellular organisms. However, the formal discovery of stem cells in the last century, followed by their intricate and extensive analysis, has led to clinical and translational efforts with the aim of using them in the treatment of conditions which don't have a definitive therapeutic strategy, has fueled our interest and expectations. Technological advances in our ability to study their cellular components in depth, along with surface markers and other finer constituents, that were unknown until last century, have improved our understanding, leading to several novel applications. This has created a need to establish guidelines, and in that process, there are expressed understandings and views which describe cell therapy along lines similar to that of biologic products, drugs, and devices. However, the age-old wisdom of using cells as tools for curing illness should not be misled by recent knowledge, to make cell therapy using highly complex stem cells equal to factory-synthesized and reproducible chemical compounds, drugs, or devices. This article analyses the differences between these two entities from various perspectives. Keywords: cell transplantation, drugs, regenerative medicine, stem cells
format	article
author	Preethy S John S Ganesh JS Srinivasan T Terunuma H Iwasaki M Abraham SJ
author_facet	Preethy S John S Ganesh JS Srinivasan T Terunuma H Iwasaki M Abraham SJ
author_sort	Preethy S
title	Age-old wisdom concerning cell-based therapies with added knowledge in the stem cell era: our perspectives
title_short	Age-old wisdom concerning cell-based therapies with added knowledge in the stem cell era: our perspectives
title_full	Age-old wisdom concerning cell-based therapies with added knowledge in the stem cell era: our perspectives
title_fullStr	Age-old wisdom concerning cell-based therapies with added knowledge in the stem cell era: our perspectives
title_full_unstemmed	Age-old wisdom concerning cell-based therapies with added knowledge in the stem cell era: our perspectives
title_sort	age-old wisdom concerning cell-based therapies with added knowledge in the stem cell era: our perspectives
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/661e6f69ac8543998991cdba17dd3ad3
work_keys_str_mv	AT preethys ageoldwisdomconcerningcellbasedtherapieswithaddedknowledgeinthestemcelleraourperspectives AT johns ageoldwisdomconcerningcellbasedtherapieswithaddedknowledgeinthestemcelleraourperspectives AT ganeshjs ageoldwisdomconcerningcellbasedtherapieswithaddedknowledgeinthestemcelleraourperspectives AT srinivasant ageoldwisdomconcerningcellbasedtherapieswithaddedknowledgeinthestemcelleraourperspectives AT terunumah ageoldwisdomconcerningcellbasedtherapieswithaddedknowledgeinthestemcelleraourperspectives AT iwasakim ageoldwisdomconcerningcellbasedtherapieswithaddedknowledgeinthestemcelleraourperspectives AT abrahamsj ageoldwisdomconcerningcellbasedtherapieswithaddedknowledgeinthestemcelleraourperspectives
_version_	1718403442621284352

Age-old wisdom concerning cell-based therapies with added knowledge in the stem cell era: our perspectives

Ejemplares similares