PAMAM Dendrimer Nanomolecules Utilized as Drug Delivery Systems for Potential Treatment of Glioblastoma: A Systematic Review

Michael Fana,1,2,* John Gallien,2,3,* Bhairavi Srinageshwar,1– 3 Gary L Dunbar,2– 5 Julien Rossignol1– 3 1College of Medicine, Central Michigan University, Mt. Pleasant, MI 48859, USA; 2Field Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan...

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Autores principales:	Fana M, Gallien J, Srinageshwar B, Dunbar GL, Rossignol J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	drug delivery glioma nanotechnology tumor astrocytoma pamam dendrimers Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/661faf7e96d94ab183006a21c0aad1f5
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spelling	oai:doaj.org-article:661faf7e96d94ab183006a21c0aad1f52021-12-02T09:54:38ZPAMAM Dendrimer Nanomolecules Utilized as Drug Delivery Systems for Potential Treatment of Glioblastoma: A Systematic Review1178-2013https://doaj.org/article/661faf7e96d94ab183006a21c0aad1f52020-04-01T00:00:00Zhttps://www.dovepress.com/pamam-dendrimer-nanomolecules-utilized-as-drug-delivery-systems-for-po-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Michael Fana,1,2,* John Gallien,2,3,* Bhairavi Srinageshwar,1– 3 Gary L Dunbar,2– 5 Julien Rossignol1– 3 1College of Medicine, Central Michigan University, Mt. Pleasant, MI 48859, USA; 2Field Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan University, Mt. Pleasant, MI 48859, USA; 3Program in Neuroscience, Central Michigan University, Mt. Pleasant, MI 48859, USA; 4Department of Psychology, Central Michigan University, Mt. Pleasant, MI 48859, USA; 5Field Neurosciences Institute, St. Mary’s of Michigan, Saginaw, MI 48604, USA*These authors contributed equally to this workCorrespondence: Julien RossignolProgram in Neuroscience and College of Medicine, Central Michigan University, 1280 S. East Campus Drive, Mount Pleasant, MI 48859 USATel +1 989-774-3405Fax +1 989-774-1215Email rossi1j@cmich.eduAbstract: Glioblastoma (GB) is a grade IV astrocytoma that maintains a poor prognosis with respect to current treatment options. Despite major advancements in the fields of surgery and chemoradiotherapy over the last few decades, the life expectancy for someone with glioblastoma remains virtually unchanged and warrants a new approach for treatment. Poly(amidoamine) (PAMAM) dendrimers are a type of nanomolecule that ranges in size (between 1 and  100 nm) and shape and can offer a new viable solution for the treatment of intracranial tumors, including glioblastoma. Their ability to deliver a variety of therapeutic cargo and penetrate the blood–brain barrier (BBB), while preserving low cytotoxicity, make them a favorable candidate for further investigation into the treatment of glioblastoma. Here, we present a systematic review of the current advancements in PAMAM dendrimer technology, including the wide spectrum of dendrimer generations formulated, surface modifications, core modifications, and conjugations developed thus far to enhance tumor specificity and tumor penetration for treatment of glioblastoma. Furthermore, we highlight the extensive variety of therapeutics capable of delivery by PAMAM dendrimers for the treatment of glioblastoma, including cytokines, peptides, drugs, siRNAs, miRNAs, and organic polyphenols. While there have been prolific results stemming from aggressive research into the field of dendrimer technology, there remains a nearly inexhaustible amount of questions that remain unanswered. Nevertheless, this technology is rapidly developing and is nearing the cusp of use for aggressive tumor treatment. To that end, we further highlight future prospects in focus as researchers continue developing more optimal vehicles for the delivery of therapeutic cargo.Keywords: drug delivery, glioma, nanotechnology, tumor, astrocytoma, PAMAM dendrimersFana MGallien JSrinageshwar BDunbar GLRossignol JDove Medical Pressarticledrug deliverygliomananotechnologytumorastrocytomapamam dendrimersMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 2789-2808 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug delivery glioma nanotechnology tumor astrocytoma pamam dendrimers Medicine (General) R5-920
spellingShingle	drug delivery glioma nanotechnology tumor astrocytoma pamam dendrimers Medicine (General) R5-920 Fana M Gallien J Srinageshwar B Dunbar GL Rossignol J PAMAM Dendrimer Nanomolecules Utilized as Drug Delivery Systems for Potential Treatment of Glioblastoma: A Systematic Review
description	Michael Fana,1,2,* John Gallien,2,3,* Bhairavi Srinageshwar,1– 3 Gary L Dunbar,2– 5 Julien Rossignol1– 3 1College of Medicine, Central Michigan University, Mt. Pleasant, MI 48859, USA; 2Field Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan University, Mt. Pleasant, MI 48859, USA; 3Program in Neuroscience, Central Michigan University, Mt. Pleasant, MI 48859, USA; 4Department of Psychology, Central Michigan University, Mt. Pleasant, MI 48859, USA; 5Field Neurosciences Institute, St. Mary’s of Michigan, Saginaw, MI 48604, USA*These authors contributed equally to this workCorrespondence: Julien RossignolProgram in Neuroscience and College of Medicine, Central Michigan University, 1280 S. East Campus Drive, Mount Pleasant, MI 48859 USATel +1 989-774-3405Fax +1 989-774-1215Email rossi1j@cmich.eduAbstract: Glioblastoma (GB) is a grade IV astrocytoma that maintains a poor prognosis with respect to current treatment options. Despite major advancements in the fields of surgery and chemoradiotherapy over the last few decades, the life expectancy for someone with glioblastoma remains virtually unchanged and warrants a new approach for treatment. Poly(amidoamine) (PAMAM) dendrimers are a type of nanomolecule that ranges in size (between 1 and  100 nm) and shape and can offer a new viable solution for the treatment of intracranial tumors, including glioblastoma. Their ability to deliver a variety of therapeutic cargo and penetrate the blood–brain barrier (BBB), while preserving low cytotoxicity, make them a favorable candidate for further investigation into the treatment of glioblastoma. Here, we present a systematic review of the current advancements in PAMAM dendrimer technology, including the wide spectrum of dendrimer generations formulated, surface modifications, core modifications, and conjugations developed thus far to enhance tumor specificity and tumor penetration for treatment of glioblastoma. Furthermore, we highlight the extensive variety of therapeutics capable of delivery by PAMAM dendrimers for the treatment of glioblastoma, including cytokines, peptides, drugs, siRNAs, miRNAs, and organic polyphenols. While there have been prolific results stemming from aggressive research into the field of dendrimer technology, there remains a nearly inexhaustible amount of questions that remain unanswered. Nevertheless, this technology is rapidly developing and is nearing the cusp of use for aggressive tumor treatment. To that end, we further highlight future prospects in focus as researchers continue developing more optimal vehicles for the delivery of therapeutic cargo.Keywords: drug delivery, glioma, nanotechnology, tumor, astrocytoma, PAMAM dendrimers
format	article
author	Fana M Gallien J Srinageshwar B Dunbar GL Rossignol J
author_facet	Fana M Gallien J Srinageshwar B Dunbar GL Rossignol J
author_sort	Fana M
title	PAMAM Dendrimer Nanomolecules Utilized as Drug Delivery Systems for Potential Treatment of Glioblastoma: A Systematic Review
title_short	PAMAM Dendrimer Nanomolecules Utilized as Drug Delivery Systems for Potential Treatment of Glioblastoma: A Systematic Review
title_full	PAMAM Dendrimer Nanomolecules Utilized as Drug Delivery Systems for Potential Treatment of Glioblastoma: A Systematic Review
title_fullStr	PAMAM Dendrimer Nanomolecules Utilized as Drug Delivery Systems for Potential Treatment of Glioblastoma: A Systematic Review
title_full_unstemmed	PAMAM Dendrimer Nanomolecules Utilized as Drug Delivery Systems for Potential Treatment of Glioblastoma: A Systematic Review
title_sort	pamam dendrimer nanomolecules utilized as drug delivery systems for potential treatment of glioblastoma: a systematic review
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/661faf7e96d94ab183006a21c0aad1f5
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PAMAM Dendrimer Nanomolecules Utilized as Drug Delivery Systems for Potential Treatment of Glioblastoma: A Systematic Review

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