Copeptin levels remain unchanged during the menstrual cycle.

<h4>Background</h4>Copeptin, a surrogate marker for arginin vasopressin production, is evaluated as an osmo-dependent stress and inflammatory biomarker in different diseases. We investigated copeptin during the menstrual cycle and its relationship to sex hormones, markers of subclinical...

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Autores principales:	Claudine A Blum, Uzma Mirza, Mirjam Christ-Crain, Beat Mueller, Christian Schindler, Jardena J Puder
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6621cea5bdbd4a6ea27b899607734a4f
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spelling	oai:doaj.org-article:6621cea5bdbd4a6ea27b899607734a4f2021-11-18T08:18:04ZCopeptin levels remain unchanged during the menstrual cycle.1932-620310.1371/journal.pone.0098240https://doaj.org/article/6621cea5bdbd4a6ea27b899607734a4f2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24866705/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Copeptin, a surrogate marker for arginin vasopressin production, is evaluated as an osmo-dependent stress and inflammatory biomarker in different diseases. We investigated copeptin during the menstrual cycle and its relationship to sex hormones, markers of subclinical inflammation and estimates of body fluid.<h4>Methods</h4>In 15 healthy women with regular menstrual cycles, blood was drawn on fifteen defined days of their menstrual cycle and was assayed for copeptin, progesterone, estradiol, luteinizing hormone, high-sensitive C-reactive protein, tumor necrosis factor-alpha and procalcitonin. Symptoms of fluid retention were assessed on each visit, and bio impedance analysis was measured thrice to estimate body fluid changes. Mixed linear model analysis was performed to assess the changes of copeptin across the menstrual cycle and the relationship of sex hormones, markers of subclinical inflammation and estimates of body fluid with copeptin.<h4>Results</h4>Copeptin levels did not significantly change during the menstrual cycle (p = 0.16). Throughout the menstrual cycle, changes in estradiol (p = 0.002) and in the physical premenstrual symptom score (p = 0.01) were positively related to copeptin, but changes in other sex hormones, in markers of subclinical inflammation or in bio impedance analysis-estimated body fluid were not (all p = ns).<h4>Conclusion</h4>Although changes in estradiol and the physical premenstrual symptom score appear to be related to copeptin changes, copeptin does not significantly change during the menstrual cycle.Claudine A BlumUzma MirzaMirjam Christ-CrainBeat MuellerChristian SchindlerJardena J PuderPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e98240 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Claudine A Blum Uzma Mirza Mirjam Christ-Crain Beat Mueller Christian Schindler Jardena J Puder Copeptin levels remain unchanged during the menstrual cycle.
description	<h4>Background</h4>Copeptin, a surrogate marker for arginin vasopressin production, is evaluated as an osmo-dependent stress and inflammatory biomarker in different diseases. We investigated copeptin during the menstrual cycle and its relationship to sex hormones, markers of subclinical inflammation and estimates of body fluid.<h4>Methods</h4>In 15 healthy women with regular menstrual cycles, blood was drawn on fifteen defined days of their menstrual cycle and was assayed for copeptin, progesterone, estradiol, luteinizing hormone, high-sensitive C-reactive protein, tumor necrosis factor-alpha and procalcitonin. Symptoms of fluid retention were assessed on each visit, and bio impedance analysis was measured thrice to estimate body fluid changes. Mixed linear model analysis was performed to assess the changes of copeptin across the menstrual cycle and the relationship of sex hormones, markers of subclinical inflammation and estimates of body fluid with copeptin.<h4>Results</h4>Copeptin levels did not significantly change during the menstrual cycle (p = 0.16). Throughout the menstrual cycle, changes in estradiol (p = 0.002) and in the physical premenstrual symptom score (p = 0.01) were positively related to copeptin, but changes in other sex hormones, in markers of subclinical inflammation or in bio impedance analysis-estimated body fluid were not (all p = ns).<h4>Conclusion</h4>Although changes in estradiol and the physical premenstrual symptom score appear to be related to copeptin changes, copeptin does not significantly change during the menstrual cycle.
format	article
author	Claudine A Blum Uzma Mirza Mirjam Christ-Crain Beat Mueller Christian Schindler Jardena J Puder
author_facet	Claudine A Blum Uzma Mirza Mirjam Christ-Crain Beat Mueller Christian Schindler Jardena J Puder
author_sort	Claudine A Blum
title	Copeptin levels remain unchanged during the menstrual cycle.
title_short	Copeptin levels remain unchanged during the menstrual cycle.
title_full	Copeptin levels remain unchanged during the menstrual cycle.
title_fullStr	Copeptin levels remain unchanged during the menstrual cycle.
title_full_unstemmed	Copeptin levels remain unchanged during the menstrual cycle.
title_sort	copeptin levels remain unchanged during the menstrual cycle.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/6621cea5bdbd4a6ea27b899607734a4f
work_keys_str_mv	AT claudineablum copeptinlevelsremainunchangedduringthemenstrualcycle AT uzmamirza copeptinlevelsremainunchangedduringthemenstrualcycle AT mirjamchristcrain copeptinlevelsremainunchangedduringthemenstrualcycle AT beatmueller copeptinlevelsremainunchangedduringthemenstrualcycle AT christianschindler copeptinlevelsremainunchangedduringthemenstrualcycle AT jardenajpuder copeptinlevelsremainunchangedduringthemenstrualcycle
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Copeptin levels remain unchanged during the menstrual cycle.

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