Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability

Recent findings suggest that forces acting on the cell nucleus can cause DNA damage, but the mechanisms are unclear. Here Takakiet al. report that actomyosin is a determinant of nuclear shape and that unrestrained contractility elicits nuclear envelope rupture and genome instability in cancer cells.

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Autores principales:	Tohru Takaki, Marco Montagner, Murielle P. Serres, Maël Le Berre, Matt Russell, Lucy Collinson, Karoly Szuhai, Michael Howell, Simon J. Boulton, Erik Sahai, Mark Petronczki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/662201e58c214629a0a38d3d261be1d7
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spelling	oai:doaj.org-article:662201e58c214629a0a38d3d261be1d72021-12-02T15:38:33ZActomyosin drives cancer cell nuclear dysmorphia and threatens genome stability10.1038/ncomms160132041-1723https://doaj.org/article/662201e58c214629a0a38d3d261be1d72017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16013https://doaj.org/toc/2041-1723Recent findings suggest that forces acting on the cell nucleus can cause DNA damage, but the mechanisms are unclear. Here Takakiet al. report that actomyosin is a determinant of nuclear shape and that unrestrained contractility elicits nuclear envelope rupture and genome instability in cancer cells.Tohru TakakiMarco MontagnerMurielle P. SerresMaël Le BerreMatt RussellLucy CollinsonKaroly SzuhaiMichael HowellSimon J. BoultonErik SahaiMark PetronczkiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tohru Takaki Marco Montagner Murielle P. Serres Maël Le Berre Matt Russell Lucy Collinson Karoly Szuhai Michael Howell Simon J. Boulton Erik Sahai Mark Petronczki Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability
description	Recent findings suggest that forces acting on the cell nucleus can cause DNA damage, but the mechanisms are unclear. Here Takakiet al. report that actomyosin is a determinant of nuclear shape and that unrestrained contractility elicits nuclear envelope rupture and genome instability in cancer cells.
format	article
author	Tohru Takaki Marco Montagner Murielle P. Serres Maël Le Berre Matt Russell Lucy Collinson Karoly Szuhai Michael Howell Simon J. Boulton Erik Sahai Mark Petronczki
author_facet	Tohru Takaki Marco Montagner Murielle P. Serres Maël Le Berre Matt Russell Lucy Collinson Karoly Szuhai Michael Howell Simon J. Boulton Erik Sahai Mark Petronczki
author_sort	Tohru Takaki
title	Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability
title_short	Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability
title_full	Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability
title_fullStr	Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability
title_full_unstemmed	Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability
title_sort	actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/662201e58c214629a0a38d3d261be1d7
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Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability

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