Evaluation of different grafting materials for alveolar cleft repair in the context of orthodontic tooth movement in rats

Abstract To minimize the postoperative risks posed by grafting autologous transplants for cleft repair, efforts are being made to improve grafting materials for use as potential alternatives. The aim of this study was to compare the bone graft quality of different bone substitutes including the gold...

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Autores principales:	Stephan Christian Möhlhenrich, Kristian Kniha, Zuzanna Magnuska, Benita Hermanns-Sachweh, Felix Gremse, Frank Hölzle, Gholamreza Danesh, Ali Modabber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6624e5da058a4d9fac8a0ff7324aaf07
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spelling	oai:doaj.org-article:6624e5da058a4d9fac8a0ff7324aaf072021-12-02T14:33:57ZEvaluation of different grafting materials for alveolar cleft repair in the context of orthodontic tooth movement in rats10.1038/s41598-021-93033-x2045-2322https://doaj.org/article/6624e5da058a4d9fac8a0ff7324aaf072021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93033-xhttps://doaj.org/toc/2045-2322Abstract To minimize the postoperative risks posed by grafting autologous transplants for cleft repair, efforts are being made to improve grafting materials for use as potential alternatives. The aim of this study was to compare the bone graft quality of different bone substitutes including the gold standard autografts during the healing processes after cleft repair in the context of orthodontic treatment. In 21 Wistar rats, a complete, continuity-interrupting cleft was created. After 4 weeks, cleft repair was performed using autografts from the hips’ ischial tuberosity, human xenografts, or synthetic bone substitutes [beta-tricalcium phosphate (β-TCP)/hydroxyapatite (HA)]. After another 4 weeks, the first molar movement was initiated in the reconstructed jaw for 8 weeks. The bone remodeling was analyzed in vivo using micro-computed tomography (bone mineral density and bone volume fraction) and histology (new bone formation). All the grafting materials were statistically different in bone morphology, which changed during the treatment period. The β-TCP/HA substitute demonstrated less resorption compared to the autologous and xenogeneic/human bone, and the autografts led to a stronger reaction in the surrounding bone. Histologically, the highest level of new bone formation was found in the human xenografts, and the lowest was found in the β-TCP/HA substitute. The differences between the two bone groups and the synthetic materials were statistically significant. Autografts were confirmed to be the gold standard in cleft repair with regard to graft integration. However, parts of the human xenograft seemed comparable to the autografts. Thus, this substitute could perhaps be used as an alternative after additional tissue-engineered modification.Stephan Christian MöhlhenrichKristian KnihaZuzanna MagnuskaBenita Hermanns-SachwehFelix GremseFrank HölzleGholamreza DaneshAli ModabberNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stephan Christian Möhlhenrich Kristian Kniha Zuzanna Magnuska Benita Hermanns-Sachweh Felix Gremse Frank Hölzle Gholamreza Danesh Ali Modabber Evaluation of different grafting materials for alveolar cleft repair in the context of orthodontic tooth movement in rats
description	Abstract To minimize the postoperative risks posed by grafting autologous transplants for cleft repair, efforts are being made to improve grafting materials for use as potential alternatives. The aim of this study was to compare the bone graft quality of different bone substitutes including the gold standard autografts during the healing processes after cleft repair in the context of orthodontic treatment. In 21 Wistar rats, a complete, continuity-interrupting cleft was created. After 4 weeks, cleft repair was performed using autografts from the hips’ ischial tuberosity, human xenografts, or synthetic bone substitutes [beta-tricalcium phosphate (β-TCP)/hydroxyapatite (HA)]. After another 4 weeks, the first molar movement was initiated in the reconstructed jaw for 8 weeks. The bone remodeling was analyzed in vivo using micro-computed tomography (bone mineral density and bone volume fraction) and histology (new bone formation). All the grafting materials were statistically different in bone morphology, which changed during the treatment period. The β-TCP/HA substitute demonstrated less resorption compared to the autologous and xenogeneic/human bone, and the autografts led to a stronger reaction in the surrounding bone. Histologically, the highest level of new bone formation was found in the human xenografts, and the lowest was found in the β-TCP/HA substitute. The differences between the two bone groups and the synthetic materials were statistically significant. Autografts were confirmed to be the gold standard in cleft repair with regard to graft integration. However, parts of the human xenograft seemed comparable to the autografts. Thus, this substitute could perhaps be used as an alternative after additional tissue-engineered modification.
format	article
author	Stephan Christian Möhlhenrich Kristian Kniha Zuzanna Magnuska Benita Hermanns-Sachweh Felix Gremse Frank Hölzle Gholamreza Danesh Ali Modabber
author_facet	Stephan Christian Möhlhenrich Kristian Kniha Zuzanna Magnuska Benita Hermanns-Sachweh Felix Gremse Frank Hölzle Gholamreza Danesh Ali Modabber
author_sort	Stephan Christian Möhlhenrich
title	Evaluation of different grafting materials for alveolar cleft repair in the context of orthodontic tooth movement in rats
title_short	Evaluation of different grafting materials for alveolar cleft repair in the context of orthodontic tooth movement in rats
title_full	Evaluation of different grafting materials for alveolar cleft repair in the context of orthodontic tooth movement in rats
title_fullStr	Evaluation of different grafting materials for alveolar cleft repair in the context of orthodontic tooth movement in rats
title_full_unstemmed	Evaluation of different grafting materials for alveolar cleft repair in the context of orthodontic tooth movement in rats
title_sort	evaluation of different grafting materials for alveolar cleft repair in the context of orthodontic tooth movement in rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6624e5da058a4d9fac8a0ff7324aaf07
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Evaluation of different grafting materials for alveolar cleft repair in the context of orthodontic tooth movement in rats

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