Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice

G Protein-Coupled Receptors (GPCRs) can adopt different conformations, each linked to distinct cellular outcomes. Here the authors show that compound 17b, a novel agonist of the GPCR family member FPR, robustly activates cardioprotective but not detrimental FPR signalling, showing beneficial therape...

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Autores principales:	Cheng Xue Qin, Lauren T. May, Renming Li, Nga Cao, Sarah Rosli, Minh Deo, Amy E. Alexander, Duncan Horlock, Jane E. Bourke, Yuan H. Yang, Alastair G. Stewart, David M. Kaye, Xiao-Jun Du, Patrick M. Sexton, Arthur Christopoulos, Xiao-Ming Gao, Rebecca H. Ritchie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/662689059cf2432b82994c3add7656fb
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spelling	oai:doaj.org-article:662689059cf2432b82994c3add7656fb2021-12-02T15:37:00ZSmall-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice10.1038/ncomms142322041-1723https://doaj.org/article/662689059cf2432b82994c3add7656fb2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14232https://doaj.org/toc/2041-1723G Protein-Coupled Receptors (GPCRs) can adopt different conformations, each linked to distinct cellular outcomes. Here the authors show that compound 17b, a novel agonist of the GPCR family member FPR, robustly activates cardioprotective but not detrimental FPR signalling, showing beneficial therapeutic effect in a mouse model of cardiac infarction.Cheng Xue QinLauren T. MayRenming LiNga CaoSarah RosliMinh DeoAmy E. AlexanderDuncan HorlockJane E. BourkeYuan H. YangAlastair G. StewartDavid M. KayeXiao-Jun DuPatrick M. SextonArthur ChristopoulosXiao-Ming GaoRebecca H. RitchieNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cheng Xue Qin Lauren T. May Renming Li Nga Cao Sarah Rosli Minh Deo Amy E. Alexander Duncan Horlock Jane E. Bourke Yuan H. Yang Alastair G. Stewart David M. Kaye Xiao-Jun Du Patrick M. Sexton Arthur Christopoulos Xiao-Ming Gao Rebecca H. Ritchie Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice
description	G Protein-Coupled Receptors (GPCRs) can adopt different conformations, each linked to distinct cellular outcomes. Here the authors show that compound 17b, a novel agonist of the GPCR family member FPR, robustly activates cardioprotective but not detrimental FPR signalling, showing beneficial therapeutic effect in a mouse model of cardiac infarction.
format	article
author	Cheng Xue Qin Lauren T. May Renming Li Nga Cao Sarah Rosli Minh Deo Amy E. Alexander Duncan Horlock Jane E. Bourke Yuan H. Yang Alastair G. Stewart David M. Kaye Xiao-Jun Du Patrick M. Sexton Arthur Christopoulos Xiao-Ming Gao Rebecca H. Ritchie
author_facet	Cheng Xue Qin Lauren T. May Renming Li Nga Cao Sarah Rosli Minh Deo Amy E. Alexander Duncan Horlock Jane E. Bourke Yuan H. Yang Alastair G. Stewart David M. Kaye Xiao-Jun Du Patrick M. Sexton Arthur Christopoulos Xiao-Ming Gao Rebecca H. Ritchie
author_sort	Cheng Xue Qin
title	Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice
title_short	Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice
title_full	Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice
title_fullStr	Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice
title_full_unstemmed	Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice
title_sort	small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/662689059cf2432b82994c3add7656fb
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Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice

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