Patent ductus arteriosus treatment trends and associated morbidities in neonates

Abstract To evaluate national epidemiologic data on infants treated for patent ductus arteriosus (PDA) in Korea and analyze outcomes associated with different PDA treatments. We retrospectively evaluated data on 12,336 patients diagnosed with PDA (International Classification of Diseases-10 code: Q2...

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Autores principales:	Joonsik Park, So J Yoon, Jungho Han, In G Song, Joohee Lim, Jeong E Shin, Ho S Eun, Kook I Park, Min S Park, Soon M Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6629daada3944a669ac48160fff98a8b
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spelling	oai:doaj.org-article:6629daada3944a669ac48160fff98a8b2021-12-02T15:45:16ZPatent ductus arteriosus treatment trends and associated morbidities in neonates10.1038/s41598-021-89868-z2045-2322https://doaj.org/article/6629daada3944a669ac48160fff98a8b2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89868-zhttps://doaj.org/toc/2045-2322Abstract To evaluate national epidemiologic data on infants treated for patent ductus arteriosus (PDA) in Korea and analyze outcomes associated with different PDA treatments. We retrospectively evaluated data on 12,336 patients diagnosed with PDA (International Classification of Diseases-10 code: Q250) between 2015 and 2018 from the Health Insurance Review and Assessment database. Among them, 1623 patients underwent surgical ligation (code: O1671). We used birth certificate data from Statistics Korea to estimate the prevalence, diagnosis, and treatment of PDA. The prevalence of infants with PDA was 81 infants per 10,000 live births and 45.2% in very low birth weight (VLBW) infants, which increased from 2015 to 2018. PDA ligation was performed in 2571 infants and 22% VLBW infants. Medical treatment was administered to 4202 infants, which decreased significantly, especially in VLBW infants (62% to 53%). The proportion of treatment was as follows: conservative treatment (53.1%), intravenous ibuprofen (24.4%), surgery (20.4%), and oral ibuprofen (10.7%); that among 4854 VLBW infants was as follows: intravenous ibuprofen (46.3%), conservative treatment (33.2%), surgery (22.2%), and oral ibuprofen (14.2%). Surgical treatment had a significantly higher risk (odds ratio 1.36) of mortality than conservative treatment. Surgical and/or medical treatments were associated with a higher risk of morbidity. Recently, increased use of conservative management of PDA has contributed to improved neonatal outcomes in VLBW infants. Select patients may still benefit from surgical ligation following careful consideration.Joonsik ParkSo J YoonJungho HanIn G SongJoohee LimJeong E ShinHo S EunKook I ParkMin S ParkSoon M LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joonsik Park So J Yoon Jungho Han In G Song Joohee Lim Jeong E Shin Ho S Eun Kook I Park Min S Park Soon M Lee Patent ductus arteriosus treatment trends and associated morbidities in neonates
description	Abstract To evaluate national epidemiologic data on infants treated for patent ductus arteriosus (PDA) in Korea and analyze outcomes associated with different PDA treatments. We retrospectively evaluated data on 12,336 patients diagnosed with PDA (International Classification of Diseases-10 code: Q250) between 2015 and 2018 from the Health Insurance Review and Assessment database. Among them, 1623 patients underwent surgical ligation (code: O1671). We used birth certificate data from Statistics Korea to estimate the prevalence, diagnosis, and treatment of PDA. The prevalence of infants with PDA was 81 infants per 10,000 live births and 45.2% in very low birth weight (VLBW) infants, which increased from 2015 to 2018. PDA ligation was performed in 2571 infants and 22% VLBW infants. Medical treatment was administered to 4202 infants, which decreased significantly, especially in VLBW infants (62% to 53%). The proportion of treatment was as follows: conservative treatment (53.1%), intravenous ibuprofen (24.4%), surgery (20.4%), and oral ibuprofen (10.7%); that among 4854 VLBW infants was as follows: intravenous ibuprofen (46.3%), conservative treatment (33.2%), surgery (22.2%), and oral ibuprofen (14.2%). Surgical treatment had a significantly higher risk (odds ratio 1.36) of mortality than conservative treatment. Surgical and/or medical treatments were associated with a higher risk of morbidity. Recently, increased use of conservative management of PDA has contributed to improved neonatal outcomes in VLBW infants. Select patients may still benefit from surgical ligation following careful consideration.
format	article
author	Joonsik Park So J Yoon Jungho Han In G Song Joohee Lim Jeong E Shin Ho S Eun Kook I Park Min S Park Soon M Lee
author_facet	Joonsik Park So J Yoon Jungho Han In G Song Joohee Lim Jeong E Shin Ho S Eun Kook I Park Min S Park Soon M Lee
author_sort	Joonsik Park
title	Patent ductus arteriosus treatment trends and associated morbidities in neonates
title_short	Patent ductus arteriosus treatment trends and associated morbidities in neonates
title_full	Patent ductus arteriosus treatment trends and associated morbidities in neonates
title_fullStr	Patent ductus arteriosus treatment trends and associated morbidities in neonates
title_full_unstemmed	Patent ductus arteriosus treatment trends and associated morbidities in neonates
title_sort	patent ductus arteriosus treatment trends and associated morbidities in neonates
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6629daada3944a669ac48160fff98a8b
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Patent ductus arteriosus treatment trends and associated morbidities in neonates

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