Joint Effects of Plasma Homocysteine Concentration and Traditional Cardiovascular Risk Factors on the Risk of New-Onset Peripheral Arterial Disease
Mengyuan Liu,1,2 Fangfang Fan,1,2 Bo Liu,1,2 Jia Jia,1,2 Yimeng Jiang,1,2 Pengfei Sun,1,2 Danmei He,1,2 Jiahui Liu,1,2 Yuxi Li,1,2 Yong Huo,1,2 Jianping Li,1,2 Yan Zhang1,2 1Department of Cardiology, Peking University First Hospital, Beijing, People’s Republic of China; 2Institute of Cardi...
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Dove Medical Press
2020
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oai:doaj.org-article:663781920cf24e32be21b4938d44392d2021-12-02T10:05:32ZJoint Effects of Plasma Homocysteine Concentration and Traditional Cardiovascular Risk Factors on the Risk of New-Onset Peripheral Arterial Disease1178-7007https://doaj.org/article/663781920cf24e32be21b4938d44392d2020-09-01T00:00:00Zhttps://www.dovepress.com/joint-effects-of-plasma-homocysteine-concentration-and-traditional-car-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Mengyuan Liu,1,2 Fangfang Fan,1,2 Bo Liu,1,2 Jia Jia,1,2 Yimeng Jiang,1,2 Pengfei Sun,1,2 Danmei He,1,2 Jiahui Liu,1,2 Yuxi Li,1,2 Yong Huo,1,2 Jianping Li,1,2 Yan Zhang1,2 1Department of Cardiology, Peking University First Hospital, Beijing, People’s Republic of China; 2Institute of Cardiovascular Disease, Peking University First Hospital, Beijing, People’s Republic of ChinaCorrespondence: Yan Zhang; Jianping Li Tel +86 10 83575262; +86 10 83575728Fax +86 10 66551383Email drzhy1108@163.com; lijianping03455@pkufh.comPurpose: Hyperhomocysteinemia is an independent risk factor for cardio- and cerebrovascular diseases. However, the relationship between plasma homocysteine (Hcy) concentration and peripheral arterial disease (PAD) has not been completely characterized. The aim of the present study was to determine the relationship between plasma Hcy concentration and new-onset PAD and to assess the effects of combinations of Hcy and traditional cardiovascular risk factors.Patients and Methods: We conducted a prospective community-based cohort study of 3119 Chinese participants who did not have PAD at baseline, with a median follow-up period of 2.30 years. We used multivariate logistic regression models to evaluate the relationship between high Hcy (≥ 10μmol/L) and new-onset PAD. The effects of combinations of high Hcy and traditional cardiovascular risk factors were assessed using logistic regression analysis.Results: After adjustment for 14 covariates, high Hcy concentration was significantly associated with new-onset PAD (odds ratio [OR]=2.08, 95% confidence interval [CI]: 1.08– 4.03, P=0.030). Smokers with high Hcy concentration were substantially more likely to have new-onset PAD than non-smokers with normal Hcy concentration (OR=4.44, 95% CI: 1.77– 11.12, P=0.001). The effect of diabetes on PAD became significant when present in combination with high Hcy concentration (OR=3.67, 95% CI: 1.25– 10.80, P=0.018). Participants with both elevated Hcy levels and older age had the highest risk of new-onset PAD (OR=4.28, 95% CI: 1.83– 10.01, P< 0.001). With regard to the joint effect of Hcy and hypertension, dyslipidemia or sex, there was also a trend towards increased risk across four different groups (P for trend=0.026, 0.035, 0.016, respectively).Conclusion: High plasma Hcy concentration independently predicts the incidence of PAD. Furthermore, there is a joint effect of high Hcy concentration and traditional cardiovascular risk factors such as smoking, diabetes and aging on the incidence of PAD.Keywords: peripheral arterial disease, atherosclerosis, hyperhomocysteinemia, cohort study, community-based populationLiu MFan FLiu BJia JJiang YSun PHe DLiu JLi YHuo YLi JZhang YDove Medical Pressarticleperipheral arterial diseaseatherosclerosishyperhomocysteinemiacohort studycommunity-based populationSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3383-3393 (2020) |
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DOAJ |
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EN |
| topic |
peripheral arterial disease atherosclerosis hyperhomocysteinemia cohort study community-based population Specialties of internal medicine RC581-951 |
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peripheral arterial disease atherosclerosis hyperhomocysteinemia cohort study community-based population Specialties of internal medicine RC581-951 Liu M Fan F Liu B Jia J Jiang Y Sun P He D Liu J Li Y Huo Y Li J Zhang Y Joint Effects of Plasma Homocysteine Concentration and Traditional Cardiovascular Risk Factors on the Risk of New-Onset Peripheral Arterial Disease |
| description |
Mengyuan Liu,1,2 Fangfang Fan,1,2 Bo Liu,1,2 Jia Jia,1,2 Yimeng Jiang,1,2 Pengfei Sun,1,2 Danmei He,1,2 Jiahui Liu,1,2 Yuxi Li,1,2 Yong Huo,1,2 Jianping Li,1,2 Yan Zhang1,2 1Department of Cardiology, Peking University First Hospital, Beijing, People’s Republic of China; 2Institute of Cardiovascular Disease, Peking University First Hospital, Beijing, People’s Republic of ChinaCorrespondence: Yan Zhang; Jianping Li Tel +86 10 83575262; +86 10 83575728Fax +86 10 66551383Email drzhy1108@163.com; lijianping03455@pkufh.comPurpose: Hyperhomocysteinemia is an independent risk factor for cardio- and cerebrovascular diseases. However, the relationship between plasma homocysteine (Hcy) concentration and peripheral arterial disease (PAD) has not been completely characterized. The aim of the present study was to determine the relationship between plasma Hcy concentration and new-onset PAD and to assess the effects of combinations of Hcy and traditional cardiovascular risk factors.Patients and Methods: We conducted a prospective community-based cohort study of 3119 Chinese participants who did not have PAD at baseline, with a median follow-up period of 2.30 years. We used multivariate logistic regression models to evaluate the relationship between high Hcy (≥ 10μmol/L) and new-onset PAD. The effects of combinations of high Hcy and traditional cardiovascular risk factors were assessed using logistic regression analysis.Results: After adjustment for 14 covariates, high Hcy concentration was significantly associated with new-onset PAD (odds ratio [OR]=2.08, 95% confidence interval [CI]: 1.08– 4.03, P=0.030). Smokers with high Hcy concentration were substantially more likely to have new-onset PAD than non-smokers with normal Hcy concentration (OR=4.44, 95% CI: 1.77– 11.12, P=0.001). The effect of diabetes on PAD became significant when present in combination with high Hcy concentration (OR=3.67, 95% CI: 1.25– 10.80, P=0.018). Participants with both elevated Hcy levels and older age had the highest risk of new-onset PAD (OR=4.28, 95% CI: 1.83– 10.01, P< 0.001). With regard to the joint effect of Hcy and hypertension, dyslipidemia or sex, there was also a trend towards increased risk across four different groups (P for trend=0.026, 0.035, 0.016, respectively).Conclusion: High plasma Hcy concentration independently predicts the incidence of PAD. Furthermore, there is a joint effect of high Hcy concentration and traditional cardiovascular risk factors such as smoking, diabetes and aging on the incidence of PAD.Keywords: peripheral arterial disease, atherosclerosis, hyperhomocysteinemia, cohort study, community-based population |
| format |
article |
| author |
Liu M Fan F Liu B Jia J Jiang Y Sun P He D Liu J Li Y Huo Y Li J Zhang Y |
| author_facet |
Liu M Fan F Liu B Jia J Jiang Y Sun P He D Liu J Li Y Huo Y Li J Zhang Y |
| author_sort |
Liu M |
| title |
Joint Effects of Plasma Homocysteine Concentration and Traditional Cardiovascular Risk Factors on the Risk of New-Onset Peripheral Arterial Disease |
| title_short |
Joint Effects of Plasma Homocysteine Concentration and Traditional Cardiovascular Risk Factors on the Risk of New-Onset Peripheral Arterial Disease |
| title_full |
Joint Effects of Plasma Homocysteine Concentration and Traditional Cardiovascular Risk Factors on the Risk of New-Onset Peripheral Arterial Disease |
| title_fullStr |
Joint Effects of Plasma Homocysteine Concentration and Traditional Cardiovascular Risk Factors on the Risk of New-Onset Peripheral Arterial Disease |
| title_full_unstemmed |
Joint Effects of Plasma Homocysteine Concentration and Traditional Cardiovascular Risk Factors on the Risk of New-Onset Peripheral Arterial Disease |
| title_sort |
joint effects of plasma homocysteine concentration and traditional cardiovascular risk factors on the risk of new-onset peripheral arterial disease |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/663781920cf24e32be21b4938d44392d |
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