Low-dose aspirin was associated with an increased risk of cardiovascular events in patients with chronic kidney disease patients and low bodyweight: results from KNOW-CKD study

Abstract The benefits and risks of aspirin therapy for patients with chronic kidney disease (CKD) who have a high burden of cardiovascular events (CVE) are controversial. To examine the effects of low-dose aspirin on major clinical outcomes in patients with CKD. As a prospective observational cohort...

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Autores principales:	Yun Jung Oh, Ae Jin Kim, Han Ro, Jae Hyun Chang, Hyun Hee Lee, Wookyung Chung, Young Youl Hyun, Joongyub Lee, Yeong Hoon Kim, Seung Hyeok Han, Dong-Wan Chae, Curie Ahn, Kook-Hwan Oh, Ji Yong Jung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6639d5a845fc4c3894accb1a26f1bfe1
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spelling	oai:doaj.org-article:6639d5a845fc4c3894accb1a26f1bfe12021-12-02T17:04:06ZLow-dose aspirin was associated with an increased risk of cardiovascular events in patients with chronic kidney disease patients and low bodyweight: results from KNOW-CKD study10.1038/s41598-021-86192-42045-2322https://doaj.org/article/6639d5a845fc4c3894accb1a26f1bfe12021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86192-4https://doaj.org/toc/2045-2322Abstract The benefits and risks of aspirin therapy for patients with chronic kidney disease (CKD) who have a high burden of cardiovascular events (CVE) are controversial. To examine the effects of low-dose aspirin on major clinical outcomes in patients with CKD. As a prospective observational cohort study, using propensity score matching, 531 aspirin recipients and non-recipients were paired for analysis from 2070 patients and fulfilled the inclusion criteria among 2238 patients with CKD. The primary outcome was the first occurrence of major CVE. The secondary outcomes were kidney events defined as a > 50% reduction of estimated glomerular filtration rate from baseline, doubling of serum creatinine, or onset of kidney failure with replacement therapy, the all-cause mortality, and bleeding event. The incidence of CVE was significantly greater in low-dose aspirin users than in non-users (HR 1.798; P = 0.011). A significant association between aspirin use and an increased risk of CVE was observed only in the lowest quartile of body weight (HR 4.014; P = 0.019) (Q1 < 60.0 kg). Secondary outcomes were not significantly different between aspirin users and non-users. It needs to be individualized of prescribing low-dose aspirin for the prevention of cardiovascular events in patients with chronic kidney disease, particularly patients with low bodyweight (< 60 kg).Yun Jung OhAe Jin KimHan RoJae Hyun ChangHyun Hee LeeWookyung ChungYoung Youl HyunJoongyub LeeYeong Hoon KimSeung Hyeok HanDong-Wan ChaeCurie AhnKook-Hwan OhJi Yong JungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yun Jung Oh Ae Jin Kim Han Ro Jae Hyun Chang Hyun Hee Lee Wookyung Chung Young Youl Hyun Joongyub Lee Yeong Hoon Kim Seung Hyeok Han Dong-Wan Chae Curie Ahn Kook-Hwan Oh Ji Yong Jung Low-dose aspirin was associated with an increased risk of cardiovascular events in patients with chronic kidney disease patients and low bodyweight: results from KNOW-CKD study
description	Abstract The benefits and risks of aspirin therapy for patients with chronic kidney disease (CKD) who have a high burden of cardiovascular events (CVE) are controversial. To examine the effects of low-dose aspirin on major clinical outcomes in patients with CKD. As a prospective observational cohort study, using propensity score matching, 531 aspirin recipients and non-recipients were paired for analysis from 2070 patients and fulfilled the inclusion criteria among 2238 patients with CKD. The primary outcome was the first occurrence of major CVE. The secondary outcomes were kidney events defined as a > 50% reduction of estimated glomerular filtration rate from baseline, doubling of serum creatinine, or onset of kidney failure with replacement therapy, the all-cause mortality, and bleeding event. The incidence of CVE was significantly greater in low-dose aspirin users than in non-users (HR 1.798; P = 0.011). A significant association between aspirin use and an increased risk of CVE was observed only in the lowest quartile of body weight (HR 4.014; P = 0.019) (Q1 < 60.0 kg). Secondary outcomes were not significantly different between aspirin users and non-users. It needs to be individualized of prescribing low-dose aspirin for the prevention of cardiovascular events in patients with chronic kidney disease, particularly patients with low bodyweight (< 60 kg).
format	article
author	Yun Jung Oh Ae Jin Kim Han Ro Jae Hyun Chang Hyun Hee Lee Wookyung Chung Young Youl Hyun Joongyub Lee Yeong Hoon Kim Seung Hyeok Han Dong-Wan Chae Curie Ahn Kook-Hwan Oh Ji Yong Jung
author_facet	Yun Jung Oh Ae Jin Kim Han Ro Jae Hyun Chang Hyun Hee Lee Wookyung Chung Young Youl Hyun Joongyub Lee Yeong Hoon Kim Seung Hyeok Han Dong-Wan Chae Curie Ahn Kook-Hwan Oh Ji Yong Jung
author_sort	Yun Jung Oh
title	Low-dose aspirin was associated with an increased risk of cardiovascular events in patients with chronic kidney disease patients and low bodyweight: results from KNOW-CKD study
title_short	Low-dose aspirin was associated with an increased risk of cardiovascular events in patients with chronic kidney disease patients and low bodyweight: results from KNOW-CKD study
title_full	Low-dose aspirin was associated with an increased risk of cardiovascular events in patients with chronic kidney disease patients and low bodyweight: results from KNOW-CKD study
title_fullStr	Low-dose aspirin was associated with an increased risk of cardiovascular events in patients with chronic kidney disease patients and low bodyweight: results from KNOW-CKD study
title_full_unstemmed	Low-dose aspirin was associated with an increased risk of cardiovascular events in patients with chronic kidney disease patients and low bodyweight: results from KNOW-CKD study
title_sort	low-dose aspirin was associated with an increased risk of cardiovascular events in patients with chronic kidney disease patients and low bodyweight: results from know-ckd study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6639d5a845fc4c3894accb1a26f1bfe1
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Low-dose aspirin was associated with an increased risk of cardiovascular events in patients with chronic kidney disease patients and low bodyweight: results from KNOW-CKD study

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