Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase

Opioid receptors are important modulators of nociceptive pain. Here the authors show that opioid receptor activation recruits peroxiredoxin 6 (PRDX6) to the receptor-Gαi complex by c-Jun N-terminal kinase, resulting in Gαi depalmitoylation and enhanced receptor-Gαi association.

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Autores principales:	Selena S. Schattauer, Benjamin B. Land, Kathryn L. Reichard, Antony D. Abraham, Lauren M. Burgeno, Jamie R. Kuhar, Paul E. M. Phillips, Shao En Ong, Charles Chavkin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/663c11deb7974a19a4ce19a91ea13d73
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spelling	oai:doaj.org-article:663c11deb7974a19a4ce19a91ea13d732021-12-02T14:42:28ZPeroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase10.1038/s41467-017-00791-22041-1723https://doaj.org/article/663c11deb7974a19a4ce19a91ea13d732017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00791-2https://doaj.org/toc/2041-1723Opioid receptors are important modulators of nociceptive pain. Here the authors show that opioid receptor activation recruits peroxiredoxin 6 (PRDX6) to the receptor-Gαi complex by c-Jun N-terminal kinase, resulting in Gαi depalmitoylation and enhanced receptor-Gαi association.Selena S. SchattauerBenjamin B. LandKathryn L. ReichardAntony D. AbrahamLauren M. BurgenoJamie R. KuharPaul E. M. PhillipsShao En OngCharles ChavkinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Selena S. Schattauer Benjamin B. Land Kathryn L. Reichard Antony D. Abraham Lauren M. Burgeno Jamie R. Kuhar Paul E. M. Phillips Shao En Ong Charles Chavkin Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase
description	Opioid receptors are important modulators of nociceptive pain. Here the authors show that opioid receptor activation recruits peroxiredoxin 6 (PRDX6) to the receptor-Gαi complex by c-Jun N-terminal kinase, resulting in Gαi depalmitoylation and enhanced receptor-Gαi association.
format	article
author	Selena S. Schattauer Benjamin B. Land Kathryn L. Reichard Antony D. Abraham Lauren M. Burgeno Jamie R. Kuhar Paul E. M. Phillips Shao En Ong Charles Chavkin
author_facet	Selena S. Schattauer Benjamin B. Land Kathryn L. Reichard Antony D. Abraham Lauren M. Burgeno Jamie R. Kuhar Paul E. M. Phillips Shao En Ong Charles Chavkin
author_sort	Selena S. Schattauer
title	Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase
title_short	Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase
title_full	Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase
title_fullStr	Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase
title_full_unstemmed	Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase
title_sort	peroxiredoxin 6 mediates gαi protein-coupled receptor inactivation by cjun kinase
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/663c11deb7974a19a4ce19a91ea13d73
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Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase

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