T1DMicro: A Clinical Risk Calculator for Type 1 Diabetes Related Microvascular Complications

Development of complications in type 1 diabetes patients can be reduced by modifying risk factors. We used a cross-sectional cohort of 1646 patients diagnosed with type 1 diabetes (T1D) to develop a clinical risk score for diabetic peripheral neuropathy (DPN), autonomic neuropathy (AN), retinopathy...

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Autores principales:	Paul Minh Huy Tran, Eileen Kim, Lynn Kim Hoang Tran, Bin Satter Khaled, Diane Hopkins, Melissa Gardiner, Jennifer Bryant, Risa Bernard, John Morgan, Bruce Bode, John Chip Reed, Jin-Xiong She, Sharad Purohit
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	type 1 diabetes complications peripheral and autonomic neuropathy retinopathy nephropathy risk prediction Medicine R
Acceso en línea:	https://doaj.org/article/663cf6939d654e99ab1701150a666691
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spelling	oai:doaj.org-article:663cf6939d654e99ab1701150a6666912021-11-11T16:14:20ZT1DMicro: A Clinical Risk Calculator for Type 1 Diabetes Related Microvascular Complications10.3390/ijerph1821110941660-46011661-7827https://doaj.org/article/663cf6939d654e99ab1701150a6666912021-10-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11094https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Development of complications in type 1 diabetes patients can be reduced by modifying risk factors. We used a cross-sectional cohort of 1646 patients diagnosed with type 1 diabetes (T1D) to develop a clinical risk score for diabetic peripheral neuropathy (DPN), autonomic neuropathy (AN), retinopathy (DR), and nephropathy (DN). Of these patients, 199 (12.1%) had DPN, 63 (3.8%) had AN, 244 (14.9%) had DR, and 88 (5.4%) had DN. We selected five variables to include in each of the four microvascular complications risk models: age, age of T1D diagnosis, duration of T1D, and average systolic blood pressure and HbA1C over the last three clinic visits. These variables were selected for their strong evidence of association with diabetic complications in the literature and because they are modifiable risk factors. We found the optimism-corrected R2 and Harrell’s C statistic were 0.39 and 0.87 for DPN, 0.24 and 0.86 for AN, 0.49 and 0.91 for DR, and 0.22 and 0.83 for DN, respectively. This tool was built to help inform patients of their current risk of microvascular complications and to motivate patients to control their HbA1c and systolic blood pressure in order to reduce their risk of these complications.Paul Minh Huy TranEileen KimLynn Kim Hoang TranBin Satter KhaledDiane HopkinsMelissa GardinerJennifer BryantRisa BernardJohn MorganBruce BodeJohn Chip ReedJin-Xiong SheSharad PurohitMDPI AGarticletype 1 diabetescomplicationsperipheral and autonomic neuropathyretinopathynephropathyrisk predictionMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11094, p 11094 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	type 1 diabetes complications peripheral and autonomic neuropathy retinopathy nephropathy risk prediction Medicine R
spellingShingle	type 1 diabetes complications peripheral and autonomic neuropathy retinopathy nephropathy risk prediction Medicine R Paul Minh Huy Tran Eileen Kim Lynn Kim Hoang Tran Bin Satter Khaled Diane Hopkins Melissa Gardiner Jennifer Bryant Risa Bernard John Morgan Bruce Bode John Chip Reed Jin-Xiong She Sharad Purohit T1DMicro: A Clinical Risk Calculator for Type 1 Diabetes Related Microvascular Complications
description	Development of complications in type 1 diabetes patients can be reduced by modifying risk factors. We used a cross-sectional cohort of 1646 patients diagnosed with type 1 diabetes (T1D) to develop a clinical risk score for diabetic peripheral neuropathy (DPN), autonomic neuropathy (AN), retinopathy (DR), and nephropathy (DN). Of these patients, 199 (12.1%) had DPN, 63 (3.8%) had AN, 244 (14.9%) had DR, and 88 (5.4%) had DN. We selected five variables to include in each of the four microvascular complications risk models: age, age of T1D diagnosis, duration of T1D, and average systolic blood pressure and HbA1C over the last three clinic visits. These variables were selected for their strong evidence of association with diabetic complications in the literature and because they are modifiable risk factors. We found the optimism-corrected R2 and Harrell’s C statistic were 0.39 and 0.87 for DPN, 0.24 and 0.86 for AN, 0.49 and 0.91 for DR, and 0.22 and 0.83 for DN, respectively. This tool was built to help inform patients of their current risk of microvascular complications and to motivate patients to control their HbA1c and systolic blood pressure in order to reduce their risk of these complications.
format	article
author	Paul Minh Huy Tran Eileen Kim Lynn Kim Hoang Tran Bin Satter Khaled Diane Hopkins Melissa Gardiner Jennifer Bryant Risa Bernard John Morgan Bruce Bode John Chip Reed Jin-Xiong She Sharad Purohit
author_facet	Paul Minh Huy Tran Eileen Kim Lynn Kim Hoang Tran Bin Satter Khaled Diane Hopkins Melissa Gardiner Jennifer Bryant Risa Bernard John Morgan Bruce Bode John Chip Reed Jin-Xiong She Sharad Purohit
author_sort	Paul Minh Huy Tran
title	T1DMicro: A Clinical Risk Calculator for Type 1 Diabetes Related Microvascular Complications
title_short	T1DMicro: A Clinical Risk Calculator for Type 1 Diabetes Related Microvascular Complications
title_full	T1DMicro: A Clinical Risk Calculator for Type 1 Diabetes Related Microvascular Complications
title_fullStr	T1DMicro: A Clinical Risk Calculator for Type 1 Diabetes Related Microvascular Complications
title_full_unstemmed	T1DMicro: A Clinical Risk Calculator for Type 1 Diabetes Related Microvascular Complications
title_sort	t1dmicro: a clinical risk calculator for type 1 diabetes related microvascular complications
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/663cf6939d654e99ab1701150a666691
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T1DMicro: A Clinical Risk Calculator for Type 1 Diabetes Related Microvascular Complications

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