Chronic medical conditions and risk of sepsis.

<h4>Background</h4>We sought to determine the associations between baseline chronic medical conditions and future risk of sepsis.<h4>Methods</h4>Longitudinal cohort study using the 30,239 community-dwelling participants of the REGARDS cohort. We determined associations betwee...

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Autores principales:	Henry E Wang, Nathan I Shapiro, Russell Griffin, Monika M Safford, Suzanne Judd, George Howard
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/663f8cc74d954de788aa4702db8bd4f2
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spelling	oai:doaj.org-article:663f8cc74d954de788aa4702db8bd4f22021-11-18T08:10:26ZChronic medical conditions and risk of sepsis.1932-620310.1371/journal.pone.0048307https://doaj.org/article/663f8cc74d954de788aa4702db8bd4f22012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23118977/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>We sought to determine the associations between baseline chronic medical conditions and future risk of sepsis.<h4>Methods</h4>Longitudinal cohort study using the 30,239 community-dwelling participants of the REGARDS cohort. We determined associations between baseline chronic medical conditions and incident sepsis episodes, defined as hospitalization for an infection with the presence of infection plus two or more systemic inflammatory response syndrome criteria.<h4>Results</h4>Over the mean observation time of 4.6 years (February 5, 2003 through October 14, 2011), there were 975 incident cases of sepsis. Incident sepsis episodes were associated with older age (p<0.001), white race (HR 1.39; 95% CI: 1.22-1.59), lower education (p<0.001) and income (p<0.001), tobacco use (p<0.001), and alcohol use (p = 0.02). Incident sepsis episodes were associated with baseline chronic lung disease (adjusted HR 2.43; 95% CI: 2.05-2.86), peripheral artery disease (2.16; 1.58-2.95), chronic kidney disease (1.99; 1.73-2.29), myocardial infarction 1.79 (1.49-2.15), diabetes 1.78 (1.53-2.07), stroke 1.67 (1.34-2.07), deep vein thrombosis 1.63 (1.29-2.06), coronary artery disease 1.61 (1.38-1.87), hypertension 1.49 (1.29-1.74), atrial fibrillation 1.48 (1.21-1.81) and dyslipidemia 1.16 (1.01-1.34). Sepsis risk increased with the number of chronic medical conditions (p<0.001).<h4>Conclusions</h4>Individuals with chronic medical conditions are at increased risk of future sepsis events.Henry E WangNathan I ShapiroRussell GriffinMonika M SaffordSuzanne JuddGeorge HowardPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e48307 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Henry E Wang Nathan I Shapiro Russell Griffin Monika M Safford Suzanne Judd George Howard Chronic medical conditions and risk of sepsis.
description	<h4>Background</h4>We sought to determine the associations between baseline chronic medical conditions and future risk of sepsis.<h4>Methods</h4>Longitudinal cohort study using the 30,239 community-dwelling participants of the REGARDS cohort. We determined associations between baseline chronic medical conditions and incident sepsis episodes, defined as hospitalization for an infection with the presence of infection plus two or more systemic inflammatory response syndrome criteria.<h4>Results</h4>Over the mean observation time of 4.6 years (February 5, 2003 through October 14, 2011), there were 975 incident cases of sepsis. Incident sepsis episodes were associated with older age (p<0.001), white race (HR 1.39; 95% CI: 1.22-1.59), lower education (p<0.001) and income (p<0.001), tobacco use (p<0.001), and alcohol use (p = 0.02). Incident sepsis episodes were associated with baseline chronic lung disease (adjusted HR 2.43; 95% CI: 2.05-2.86), peripheral artery disease (2.16; 1.58-2.95), chronic kidney disease (1.99; 1.73-2.29), myocardial infarction 1.79 (1.49-2.15), diabetes 1.78 (1.53-2.07), stroke 1.67 (1.34-2.07), deep vein thrombosis 1.63 (1.29-2.06), coronary artery disease 1.61 (1.38-1.87), hypertension 1.49 (1.29-1.74), atrial fibrillation 1.48 (1.21-1.81) and dyslipidemia 1.16 (1.01-1.34). Sepsis risk increased with the number of chronic medical conditions (p<0.001).<h4>Conclusions</h4>Individuals with chronic medical conditions are at increased risk of future sepsis events.
format	article
author	Henry E Wang Nathan I Shapiro Russell Griffin Monika M Safford Suzanne Judd George Howard
author_facet	Henry E Wang Nathan I Shapiro Russell Griffin Monika M Safford Suzanne Judd George Howard
author_sort	Henry E Wang
title	Chronic medical conditions and risk of sepsis.
title_short	Chronic medical conditions and risk of sepsis.
title_full	Chronic medical conditions and risk of sepsis.
title_fullStr	Chronic medical conditions and risk of sepsis.
title_full_unstemmed	Chronic medical conditions and risk of sepsis.
title_sort	chronic medical conditions and risk of sepsis.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/663f8cc74d954de788aa4702db8bd4f2
work_keys_str_mv	AT henryewang chronicmedicalconditionsandriskofsepsis AT nathanishapiro chronicmedicalconditionsandriskofsepsis AT russellgriffin chronicmedicalconditionsandriskofsepsis AT monikamsafford chronicmedicalconditionsandriskofsepsis AT suzannejudd chronicmedicalconditionsandriskofsepsis AT georgehoward chronicmedicalconditionsandriskofsepsis
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Chronic medical conditions and risk of sepsis.

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