T1 Relaxation Times in the Cortex and Thalamus Are Associated With Working Memory and Information Processing Speed in Patients With Multiple Sclerosis

Background: Cortical and thalamic pathologies have been associated with cognitive impairment in patients with multiple sclerosis (MS).Objective: We aimed to quantify cortical and thalamic damage in patients with MS using a high-resolution T1 mapping technique and to evaluate the association of these...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Christian Thaler, Isabelle Hartramph, Jan-Patrick Stellmann, Christoph Heesen, Maxim Bester, Jens Fiehler, Susanne Gellißen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	T1 relaxometry multiple sclerosis cognitive impairment quantitative MRI thalamus T1 relaxation time Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/6640a429f03548ecb32435296c4e89c6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6640a429f03548ecb32435296c4e89c6
record_format	dspace
spelling	oai:doaj.org-article:6640a429f03548ecb32435296c4e89c62021-12-03T05:28:43ZT1 Relaxation Times in the Cortex and Thalamus Are Associated With Working Memory and Information Processing Speed in Patients With Multiple Sclerosis1664-229510.3389/fneur.2021.789812https://doaj.org/article/6640a429f03548ecb32435296c4e89c62021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.789812/fullhttps://doaj.org/toc/1664-2295Background: Cortical and thalamic pathologies have been associated with cognitive impairment in patients with multiple sclerosis (MS).Objective: We aimed to quantify cortical and thalamic damage in patients with MS using a high-resolution T1 mapping technique and to evaluate the association of these changes with clinical and cognitive impairment.Methods: The study group consisted of 49 patients with mainly relapsing-remitting MS and 17 age-matched healthy controls who received 3T MRIs including a T1 mapping sequence (MP2RAGE). Mean T1 relaxation times (T1-RT) in the cortex and thalami were compared between patients with MS and healthy controls. Additionally, correlation analysis was performed to assess the relationship between MRI parameters and clinical and cognitive disability.Results: Patients with MS had significantly decreased normalized brain, gray matter, and white matter volumes, as well as increased T1-RT in the normal-appearing white matter, compared to healthy controls (p < 0.001). Partial correlation analysis with age, sex, and disease duration as covariates revealed correlations for T1-RT in the cortex (r = −0.33, p < 0.05), and thalami (right thalamus: r = −0.37, left thalamus: r = −0.50, both p < 0.05) with working memory and information processing speed, as measured by the Symbol-Digit Modalities Test.Conclusion: T1-RT in the cortex and thalamus correlate with information processing speed in patients with MS.Christian ThalerIsabelle HartramphJan-Patrick StellmannJan-Patrick StellmannJan-Patrick StellmannJan-Patrick StellmannChristoph HeesenChristoph HeesenMaxim BesterJens FiehlerSusanne GellißenFrontiers Media S.A.articleT1 relaxometrymultiple sclerosiscognitive impairmentquantitative MRIthalamusT1 relaxation timeNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	T1 relaxometry multiple sclerosis cognitive impairment quantitative MRI thalamus T1 relaxation time Neurology. Diseases of the nervous system RC346-429
spellingShingle	T1 relaxometry multiple sclerosis cognitive impairment quantitative MRI thalamus T1 relaxation time Neurology. Diseases of the nervous system RC346-429 Christian Thaler Isabelle Hartramph Jan-Patrick Stellmann Jan-Patrick Stellmann Jan-Patrick Stellmann Jan-Patrick Stellmann Christoph Heesen Christoph Heesen Maxim Bester Jens Fiehler Susanne Gellißen T1 Relaxation Times in the Cortex and Thalamus Are Associated With Working Memory and Information Processing Speed in Patients With Multiple Sclerosis
description	Background: Cortical and thalamic pathologies have been associated with cognitive impairment in patients with multiple sclerosis (MS).Objective: We aimed to quantify cortical and thalamic damage in patients with MS using a high-resolution T1 mapping technique and to evaluate the association of these changes with clinical and cognitive impairment.Methods: The study group consisted of 49 patients with mainly relapsing-remitting MS and 17 age-matched healthy controls who received 3T MRIs including a T1 mapping sequence (MP2RAGE). Mean T1 relaxation times (T1-RT) in the cortex and thalami were compared between patients with MS and healthy controls. Additionally, correlation analysis was performed to assess the relationship between MRI parameters and clinical and cognitive disability.Results: Patients with MS had significantly decreased normalized brain, gray matter, and white matter volumes, as well as increased T1-RT in the normal-appearing white matter, compared to healthy controls (p < 0.001). Partial correlation analysis with age, sex, and disease duration as covariates revealed correlations for T1-RT in the cortex (r = −0.33, p < 0.05), and thalami (right thalamus: r = −0.37, left thalamus: r = −0.50, both p < 0.05) with working memory and information processing speed, as measured by the Symbol-Digit Modalities Test.Conclusion: T1-RT in the cortex and thalamus correlate with information processing speed in patients with MS.
format	article
author	Christian Thaler Isabelle Hartramph Jan-Patrick Stellmann Jan-Patrick Stellmann Jan-Patrick Stellmann Jan-Patrick Stellmann Christoph Heesen Christoph Heesen Maxim Bester Jens Fiehler Susanne Gellißen
author_facet	Christian Thaler Isabelle Hartramph Jan-Patrick Stellmann Jan-Patrick Stellmann Jan-Patrick Stellmann Jan-Patrick Stellmann Christoph Heesen Christoph Heesen Maxim Bester Jens Fiehler Susanne Gellißen
author_sort	Christian Thaler
title	T1 Relaxation Times in the Cortex and Thalamus Are Associated With Working Memory and Information Processing Speed in Patients With Multiple Sclerosis
title_short	T1 Relaxation Times in the Cortex and Thalamus Are Associated With Working Memory and Information Processing Speed in Patients With Multiple Sclerosis
title_full	T1 Relaxation Times in the Cortex and Thalamus Are Associated With Working Memory and Information Processing Speed in Patients With Multiple Sclerosis
title_fullStr	T1 Relaxation Times in the Cortex and Thalamus Are Associated With Working Memory and Information Processing Speed in Patients With Multiple Sclerosis
title_full_unstemmed	T1 Relaxation Times in the Cortex and Thalamus Are Associated With Working Memory and Information Processing Speed in Patients With Multiple Sclerosis
title_sort	t1 relaxation times in the cortex and thalamus are associated with working memory and information processing speed in patients with multiple sclerosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6640a429f03548ecb32435296c4e89c6
work_keys_str_mv	AT christianthaler t1relaxationtimesinthecortexandthalamusareassociatedwithworkingmemoryandinformationprocessingspeedinpatientswithmultiplesclerosis AT isabellehartramph t1relaxationtimesinthecortexandthalamusareassociatedwithworkingmemoryandinformationprocessingspeedinpatientswithmultiplesclerosis AT janpatrickstellmann t1relaxationtimesinthecortexandthalamusareassociatedwithworkingmemoryandinformationprocessingspeedinpatientswithmultiplesclerosis AT janpatrickstellmann t1relaxationtimesinthecortexandthalamusareassociatedwithworkingmemoryandinformationprocessingspeedinpatientswithmultiplesclerosis AT janpatrickstellmann t1relaxationtimesinthecortexandthalamusareassociatedwithworkingmemoryandinformationprocessingspeedinpatientswithmultiplesclerosis AT janpatrickstellmann t1relaxationtimesinthecortexandthalamusareassociatedwithworkingmemoryandinformationprocessingspeedinpatientswithmultiplesclerosis AT christophheesen t1relaxationtimesinthecortexandthalamusareassociatedwithworkingmemoryandinformationprocessingspeedinpatientswithmultiplesclerosis AT christophheesen t1relaxationtimesinthecortexandthalamusareassociatedwithworkingmemoryandinformationprocessingspeedinpatientswithmultiplesclerosis AT maximbester t1relaxationtimesinthecortexandthalamusareassociatedwithworkingmemoryandinformationprocessingspeedinpatientswithmultiplesclerosis AT jensfiehler t1relaxationtimesinthecortexandthalamusareassociatedwithworkingmemoryandinformationprocessingspeedinpatientswithmultiplesclerosis AT susannegellißen t1relaxationtimesinthecortexandthalamusareassociatedwithworkingmemoryandinformationprocessingspeedinpatientswithmultiplesclerosis
_version_	1718373934649311232

T1 Relaxation Times in the Cortex and Thalamus Are Associated With Working Memory and Information Processing Speed in Patients With Multiple Sclerosis

Ejemplares similares