The Relationship Between Serum VCAM-1 and Alzheimer’s Disease in Patients with Type 2 Diabetes Mellitus
Lingyun Zhang,1 Huawu Mao2 1Department of Laboratory Medicine, Zutangshan Hospital, Nanjing 211153, Jiangsu, People’s Republic of China; 2Department of Neurology, Taizhou Second People’s Hospital, Taizhou 225500, Jiangsu, People’s Republic of ChinaCorrespondence: Huawu...
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Dove Medical Press
2020
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oai:doaj.org-article:664219256a954280ba5ee890192196372021-12-02T13:02:37ZThe Relationship Between Serum VCAM-1 and Alzheimer’s Disease in Patients with Type 2 Diabetes Mellitus1178-7007https://doaj.org/article/664219256a954280ba5ee890192196372020-11-01T00:00:00Zhttps://www.dovepress.com/the-relationship-between-serum-vcam-1-and-alzheimerrsquos-disease-in-p-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Lingyun Zhang,1 Huawu Mao2 1Department of Laboratory Medicine, Zutangshan Hospital, Nanjing 211153, Jiangsu, People’s Republic of China; 2Department of Neurology, Taizhou Second People’s Hospital, Taizhou 225500, Jiangsu, People’s Republic of ChinaCorrespondence: Huawu MaoDepartment of Neurology, Taizhou Second People’s Hospital, NO. 27 Jiankang Road, Jiangyan District, Taizhou City 225500, Jiangsu, People’s Republic of ChinaTel +86 52388245686Email 3126376830@qq.comBackground: Previous studies have reported that diabetes mellitus (DM) is a risk factor for Alzheimer’s disease (AD). Vascular cell adhesion molecule-1 (VCAM-1) plays an important role in the pathological process of atherosclerosis. The aim was to elucidate the relationship between serum VCAM-1 and early AD in DM patients.Methods: Serum samples for VCAM-1 were tested in 208 DM patients. All included DM patients were followed up for a median of 36 months prospectively. The prognostic value of serum VCAM-1 for predicting AD events was analyzed by using Cox proportional hazard.Results: Serum VCAM-1 was independently associated with AD history after adjusting for related confounding factors in patients with DM at baseline by using the logistic regression analysis (OR=1.861; 95% CI, 1.435– 2.539; Ptrend=0.020). The Cox proportional hazard model suggested that VCAM-1 was a prognostic factor for AD events in the DM patients (HR=2.728; 95% CI, 1.785– 5.439; Ptrend< 0.001). Stratified analysis showed that the significant association between AD event and serum VCAM-1 in DM patients was not affective by CVD history.Conclusion: Our results showed that higher VCAM-1 levels were significantly related to a higher risk of AD events in DM patients. The serum biomarker might be beneficial to predict AD early. Serum VCAM-1 might be a good biochemical parameter for predicting AD in DM.Keywords: diabetes mellitus, Alzheimer’s disease, vascular cell adhesion molecule-1, prognostic valueZhang LMao HDove Medical Pressarticlediabetes mellitusalzheimer’s disease，vascular cell adhesion molecule-1prognostic valueSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 4661-4667 (2020) |
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DOAJ |
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DOAJ |
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EN |
| topic |
diabetes mellitus alzheimer’s disease，vascular cell adhesion molecule-1 prognostic value Specialties of internal medicine RC581-951 |
| spellingShingle |
diabetes mellitus alzheimer’s disease，vascular cell adhesion molecule-1 prognostic value Specialties of internal medicine RC581-951 Zhang L Mao H The Relationship Between Serum VCAM-1 and Alzheimer’s Disease in Patients with Type 2 Diabetes Mellitus |
| description |
Lingyun Zhang,1 Huawu Mao2 1Department of Laboratory Medicine, Zutangshan Hospital, Nanjing 211153, Jiangsu, People’s Republic of China; 2Department of Neurology, Taizhou Second People’s Hospital, Taizhou 225500, Jiangsu, People’s Republic of ChinaCorrespondence: Huawu MaoDepartment of Neurology, Taizhou Second People’s Hospital, NO. 27 Jiankang Road, Jiangyan District, Taizhou City 225500, Jiangsu, People’s Republic of ChinaTel +86 52388245686Email 3126376830@qq.comBackground: Previous studies have reported that diabetes mellitus (DM) is a risk factor for Alzheimer’s disease (AD). Vascular cell adhesion molecule-1 (VCAM-1) plays an important role in the pathological process of atherosclerosis. The aim was to elucidate the relationship between serum VCAM-1 and early AD in DM patients.Methods: Serum samples for VCAM-1 were tested in 208 DM patients. All included DM patients were followed up for a median of 36 months prospectively. The prognostic value of serum VCAM-1 for predicting AD events was analyzed by using Cox proportional hazard.Results: Serum VCAM-1 was independently associated with AD history after adjusting for related confounding factors in patients with DM at baseline by using the logistic regression analysis (OR=1.861; 95% CI, 1.435– 2.539; Ptrend=0.020). The Cox proportional hazard model suggested that VCAM-1 was a prognostic factor for AD events in the DM patients (HR=2.728; 95% CI, 1.785– 5.439; Ptrend< 0.001). Stratified analysis showed that the significant association between AD event and serum VCAM-1 in DM patients was not affective by CVD history.Conclusion: Our results showed that higher VCAM-1 levels were significantly related to a higher risk of AD events in DM patients. The serum biomarker might be beneficial to predict AD early. Serum VCAM-1 might be a good biochemical parameter for predicting AD in DM.Keywords: diabetes mellitus, Alzheimer’s disease, vascular cell adhesion molecule-1, prognostic value |
| format |
article |
| author |
Zhang L Mao H |
| author_facet |
Zhang L Mao H |
| author_sort |
Zhang L |
| title |
The Relationship Between Serum VCAM-1 and Alzheimer’s Disease in Patients with Type 2 Diabetes Mellitus |
| title_short |
The Relationship Between Serum VCAM-1 and Alzheimer’s Disease in Patients with Type 2 Diabetes Mellitus |
| title_full |
The Relationship Between Serum VCAM-1 and Alzheimer’s Disease in Patients with Type 2 Diabetes Mellitus |
| title_fullStr |
The Relationship Between Serum VCAM-1 and Alzheimer’s Disease in Patients with Type 2 Diabetes Mellitus |
| title_full_unstemmed |
The Relationship Between Serum VCAM-1 and Alzheimer’s Disease in Patients with Type 2 Diabetes Mellitus |
| title_sort |
relationship between serum vcam-1 and alzheimer’s disease in patients with type 2 diabetes mellitus |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/664219256a954280ba5ee89019219637 |
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