LSH mediates gene repression through macroH2A deposition

The human ICF 4 syndrome is caused by mutation of the chromatin remodeller LSH. Here, the authors show that LSH depletion disrupts the ability of histone variant macroH2A to insert into chromatin and silence transcription.

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Autores principales:	Kai Ni, Jianke Ren, Xiaoping Xu, Yafeng He, Richard Finney, Simon M. G. Braun, Nathaniel A. Hathaway, Gerald R. Crabtree, Kathrin Muegge
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6643f55537234e79b58f4c93aa3e4891
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id	oai:doaj.org-article:6643f55537234e79b58f4c93aa3e4891
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spelling	oai:doaj.org-article:6643f55537234e79b58f4c93aa3e48912021-12-02T17:32:43ZLSH mediates gene repression through macroH2A deposition10.1038/s41467-020-19159-02041-1723https://doaj.org/article/6643f55537234e79b58f4c93aa3e48912020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19159-0https://doaj.org/toc/2041-1723The human ICF 4 syndrome is caused by mutation of the chromatin remodeller LSH. Here, the authors show that LSH depletion disrupts the ability of histone variant macroH2A to insert into chromatin and silence transcription.Kai NiJianke RenXiaoping XuYafeng HeRichard FinneySimon M. G. BraunNathaniel A. HathawayGerald R. CrabtreeKathrin MueggeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kai Ni Jianke Ren Xiaoping Xu Yafeng He Richard Finney Simon M. G. Braun Nathaniel A. Hathaway Gerald R. Crabtree Kathrin Muegge LSH mediates gene repression through macroH2A deposition
description	The human ICF 4 syndrome is caused by mutation of the chromatin remodeller LSH. Here, the authors show that LSH depletion disrupts the ability of histone variant macroH2A to insert into chromatin and silence transcription.
format	article
author	Kai Ni Jianke Ren Xiaoping Xu Yafeng He Richard Finney Simon M. G. Braun Nathaniel A. Hathaway Gerald R. Crabtree Kathrin Muegge
author_facet	Kai Ni Jianke Ren Xiaoping Xu Yafeng He Richard Finney Simon M. G. Braun Nathaniel A. Hathaway Gerald R. Crabtree Kathrin Muegge
author_sort	Kai Ni
title	LSH mediates gene repression through macroH2A deposition
title_short	LSH mediates gene repression through macroH2A deposition
title_full	LSH mediates gene repression through macroH2A deposition
title_fullStr	LSH mediates gene repression through macroH2A deposition
title_full_unstemmed	LSH mediates gene repression through macroH2A deposition
title_sort	lsh mediates gene repression through macroh2a deposition
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6643f55537234e79b58f4c93aa3e4891
work_keys_str_mv	AT kaini lshmediatesgenerepressionthroughmacroh2adeposition AT jiankeren lshmediatesgenerepressionthroughmacroh2adeposition AT xiaopingxu lshmediatesgenerepressionthroughmacroh2adeposition AT yafenghe lshmediatesgenerepressionthroughmacroh2adeposition AT richardfinney lshmediatesgenerepressionthroughmacroh2adeposition AT simonmgbraun lshmediatesgenerepressionthroughmacroh2adeposition AT nathanielahathaway lshmediatesgenerepressionthroughmacroh2adeposition AT geraldrcrabtree lshmediatesgenerepressionthroughmacroh2adeposition AT kathrinmuegge lshmediatesgenerepressionthroughmacroh2adeposition
_version_	1718380190273372160

LSH mediates gene repression through macroH2A deposition

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