Automated quantification of posterior vitreous inflammation: optical coherence tomography scan number requirements

Abstract Quantifying intraocular inflammation is crucial in managing uveitis patients. We assessed the minimum B-scan density for reliable automated vitreous intensity (VI) assessment, using a novel approach based on optical coherence tomography (OCT). OCT volume scans centered on the macula were re...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jan Henrik Terheyden, Giovanni Ometto, Giovanni Montesano, Maximilian W. M. Wintergerst, Magdalena Langner, Xiaoxuan Liu, Pearse A. Keane, David P. Crabb, Alastair K. Denniston, Robert P. Finger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/664cd5c275b14bed9e7828d0955a0080
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:664cd5c275b14bed9e7828d0955a0080
record_format	dspace
spelling	oai:doaj.org-article:664cd5c275b14bed9e7828d0955a00802021-12-02T12:09:18ZAutomated quantification of posterior vitreous inflammation: optical coherence tomography scan number requirements10.1038/s41598-021-82786-02045-2322https://doaj.org/article/664cd5c275b14bed9e7828d0955a00802021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82786-0https://doaj.org/toc/2045-2322Abstract Quantifying intraocular inflammation is crucial in managing uveitis patients. We assessed the minimum B-scan density for reliable automated vitreous intensity (VI) assessment, using a novel approach based on optical coherence tomography (OCT). OCT volume scans centered on the macula were retrospectively collected in patients with uveitis. Nine B-scans per volume scan at fixed locations were automatically analyzed. The following B-scan selections were compared against the average score of 9 B-scans per volume scan as a reference standard: 1/3/5/7 central scans (1c/3c/5c/7c), 3 widely distributed scans (3w). Image data of 49 patients (31 females) were included. The median VI was 0.029 (IQR: 0.032). The intra-class-correlation coefficient of the VI across the 9 B-scans was 0.923. The median difference from the reference standard ranged between 0.001 (7c) and 0.006 (1c). It was significantly lower for scan selection 3w than 5c, p(adjusted) = 0.022, and lower for selection 7c than 3w, p(adjusted) = 0.003. The scan selections 7c and 3w showed the two highest areas under the receiver operating curve (0.985 and 0.965, respectively). Three widely distributed B-scans are sufficient to quantify VI reliably. Highest reliability was achieved using 7 central B-scans. Automated quantification of VI in uveitis is reliable and requires only few OCT B-scans.Jan Henrik TerheydenGiovanni OmettoGiovanni MontesanoMaximilian W. M. WintergerstMagdalena LangnerXiaoxuan LiuPearse A. KeaneDavid P. CrabbAlastair K. DennistonRobert P. FingerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jan Henrik Terheyden Giovanni Ometto Giovanni Montesano Maximilian W. M. Wintergerst Magdalena Langner Xiaoxuan Liu Pearse A. Keane David P. Crabb Alastair K. Denniston Robert P. Finger Automated quantification of posterior vitreous inflammation: optical coherence tomography scan number requirements
description	Abstract Quantifying intraocular inflammation is crucial in managing uveitis patients. We assessed the minimum B-scan density for reliable automated vitreous intensity (VI) assessment, using a novel approach based on optical coherence tomography (OCT). OCT volume scans centered on the macula were retrospectively collected in patients with uveitis. Nine B-scans per volume scan at fixed locations were automatically analyzed. The following B-scan selections were compared against the average score of 9 B-scans per volume scan as a reference standard: 1/3/5/7 central scans (1c/3c/5c/7c), 3 widely distributed scans (3w). Image data of 49 patients (31 females) were included. The median VI was 0.029 (IQR: 0.032). The intra-class-correlation coefficient of the VI across the 9 B-scans was 0.923. The median difference from the reference standard ranged between 0.001 (7c) and 0.006 (1c). It was significantly lower for scan selection 3w than 5c, p(adjusted) = 0.022, and lower for selection 7c than 3w, p(adjusted) = 0.003. The scan selections 7c and 3w showed the two highest areas under the receiver operating curve (0.985 and 0.965, respectively). Three widely distributed B-scans are sufficient to quantify VI reliably. Highest reliability was achieved using 7 central B-scans. Automated quantification of VI in uveitis is reliable and requires only few OCT B-scans.
format	article
author	Jan Henrik Terheyden Giovanni Ometto Giovanni Montesano Maximilian W. M. Wintergerst Magdalena Langner Xiaoxuan Liu Pearse A. Keane David P. Crabb Alastair K. Denniston Robert P. Finger
author_facet	Jan Henrik Terheyden Giovanni Ometto Giovanni Montesano Maximilian W. M. Wintergerst Magdalena Langner Xiaoxuan Liu Pearse A. Keane David P. Crabb Alastair K. Denniston Robert P. Finger
author_sort	Jan Henrik Terheyden
title	Automated quantification of posterior vitreous inflammation: optical coherence tomography scan number requirements
title_short	Automated quantification of posterior vitreous inflammation: optical coherence tomography scan number requirements
title_full	Automated quantification of posterior vitreous inflammation: optical coherence tomography scan number requirements
title_fullStr	Automated quantification of posterior vitreous inflammation: optical coherence tomography scan number requirements
title_full_unstemmed	Automated quantification of posterior vitreous inflammation: optical coherence tomography scan number requirements
title_sort	automated quantification of posterior vitreous inflammation: optical coherence tomography scan number requirements
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/664cd5c275b14bed9e7828d0955a0080
work_keys_str_mv	AT janhenrikterheyden automatedquantificationofposteriorvitreousinflammationopticalcoherencetomographyscannumberrequirements AT giovanniometto automatedquantificationofposteriorvitreousinflammationopticalcoherencetomographyscannumberrequirements AT giovannimontesano automatedquantificationofposteriorvitreousinflammationopticalcoherencetomographyscannumberrequirements AT maximilianwmwintergerst automatedquantificationofposteriorvitreousinflammationopticalcoherencetomographyscannumberrequirements AT magdalenalangner automatedquantificationofposteriorvitreousinflammationopticalcoherencetomographyscannumberrequirements AT xiaoxuanliu automatedquantificationofposteriorvitreousinflammationopticalcoherencetomographyscannumberrequirements AT pearseakeane automatedquantificationofposteriorvitreousinflammationopticalcoherencetomographyscannumberrequirements AT davidpcrabb automatedquantificationofposteriorvitreousinflammationopticalcoherencetomographyscannumberrequirements AT alastairkdenniston automatedquantificationofposteriorvitreousinflammationopticalcoherencetomographyscannumberrequirements AT robertpfinger automatedquantificationofposteriorvitreousinflammationopticalcoherencetomographyscannumberrequirements
_version_	1718394694200721408

Automated quantification of posterior vitreous inflammation: optical coherence tomography scan number requirements

Ejemplares similares