Microbiota composition of the koala (Phascolarctos cinereus) ocular and urogenital sites, and their association with Chlamydia infection and disease

Abstract Disease caused by Chlamydia pecorum is characterised by ocular and urogenital infections that can lead to blindness and infertility in koalas. However, koalas that are infected with C. pecorum do not always progress to disease. In other host systems, the influence of the microbiota has been...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Miranda E. Vidgen, Jonathan Hanger, Peter Timms
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/665561f2c3a24b63a84d6074190ea79b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:665561f2c3a24b63a84d6074190ea79b
record_format	dspace
spelling	oai:doaj.org-article:665561f2c3a24b63a84d6074190ea79b2021-12-02T11:40:32ZMicrobiota composition of the koala (Phascolarctos cinereus) ocular and urogenital sites, and their association with Chlamydia infection and disease10.1038/s41598-017-05454-22045-2322https://doaj.org/article/665561f2c3a24b63a84d6074190ea79b2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05454-2https://doaj.org/toc/2045-2322Abstract Disease caused by Chlamydia pecorum is characterised by ocular and urogenital infections that can lead to blindness and infertility in koalas. However, koalas that are infected with C. pecorum do not always progress to disease. In other host systems, the influence of the microbiota has been implicated in either accelerating or preventing infections progressing to disease. This study investigates the contribution of koala urogenital and ocular microbiota to Chlamydia infection and disease in a free ranging koala population. Using univariate and multivariate analysis, it was found that reproductive status in females and sexual maturation in males, were defining features in the koala urogenital microbiota. Changes in the urogenital microbiota of koalas is correlated with infection by the common pathogen, C. pecorum. The correlation of microbiota composition and C. pecorum infection is suggestive of members of the microbiota being involved in the acceleration or prevention of infections progressing to disease. The analysis also suggests that multiple microbes are likely to be associated with this process of disease progression, rather than a single organism. While other Chlamydia-like organisms were also detected, they are unlikely to contribute to chlamydial disease as they are rare members of the urogenital and ocular microbiota communities.Miranda E. VidgenJonathan HangerPeter TimmsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Miranda E. Vidgen Jonathan Hanger Peter Timms Microbiota composition of the koala (Phascolarctos cinereus) ocular and urogenital sites, and their association with Chlamydia infection and disease
description	Abstract Disease caused by Chlamydia pecorum is characterised by ocular and urogenital infections that can lead to blindness and infertility in koalas. However, koalas that are infected with C. pecorum do not always progress to disease. In other host systems, the influence of the microbiota has been implicated in either accelerating or preventing infections progressing to disease. This study investigates the contribution of koala urogenital and ocular microbiota to Chlamydia infection and disease in a free ranging koala population. Using univariate and multivariate analysis, it was found that reproductive status in females and sexual maturation in males, were defining features in the koala urogenital microbiota. Changes in the urogenital microbiota of koalas is correlated with infection by the common pathogen, C. pecorum. The correlation of microbiota composition and C. pecorum infection is suggestive of members of the microbiota being involved in the acceleration or prevention of infections progressing to disease. The analysis also suggests that multiple microbes are likely to be associated with this process of disease progression, rather than a single organism. While other Chlamydia-like organisms were also detected, they are unlikely to contribute to chlamydial disease as they are rare members of the urogenital and ocular microbiota communities.
format	article
author	Miranda E. Vidgen Jonathan Hanger Peter Timms
author_facet	Miranda E. Vidgen Jonathan Hanger Peter Timms
author_sort	Miranda E. Vidgen
title	Microbiota composition of the koala (Phascolarctos cinereus) ocular and urogenital sites, and their association with Chlamydia infection and disease
title_short	Microbiota composition of the koala (Phascolarctos cinereus) ocular and urogenital sites, and their association with Chlamydia infection and disease
title_full	Microbiota composition of the koala (Phascolarctos cinereus) ocular and urogenital sites, and their association with Chlamydia infection and disease
title_fullStr	Microbiota composition of the koala (Phascolarctos cinereus) ocular and urogenital sites, and their association with Chlamydia infection and disease
title_full_unstemmed	Microbiota composition of the koala (Phascolarctos cinereus) ocular and urogenital sites, and their association with Chlamydia infection and disease
title_sort	microbiota composition of the koala (phascolarctos cinereus) ocular and urogenital sites, and their association with chlamydia infection and disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/665561f2c3a24b63a84d6074190ea79b
work_keys_str_mv	AT mirandaevidgen microbiotacompositionofthekoalaphascolarctoscinereusocularandurogenitalsitesandtheirassociationwithchlamydiainfectionanddisease AT jonathanhanger microbiotacompositionofthekoalaphascolarctoscinereusocularandurogenitalsitesandtheirassociationwithchlamydiainfectionanddisease AT petertimms microbiotacompositionofthekoalaphascolarctoscinereusocularandurogenitalsitesandtheirassociationwithchlamydiainfectionanddisease
_version_	1718395586022998016

Microbiota composition of the koala (Phascolarctos cinereus) ocular and urogenital sites, and their association with Chlamydia infection and disease

Ejemplares similares