Foldamer-mediated manipulation of a pre-amyloid toxin

Intrinsically disordered proteins that form amyloid fibrils are hard to target with traditional therapeutic approaches. Here, the authors report on an oligoquinoline derivative that binds the human islet amyloid polypeptide, stabilising an alpha-helical structure that reduces its cellular toxicity.

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Autores principales:	Sunil Kumar, Melissa Birol, Diana E. Schlamadinger, Slawomir P. Wojcik, Elizabeth Rhoades, Andrew D. Miranker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/665697c8a506443f9f23cfe44a5d3983
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id	oai:doaj.org-article:665697c8a506443f9f23cfe44a5d3983
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spelling	oai:doaj.org-article:665697c8a506443f9f23cfe44a5d39832021-12-02T15:35:26ZFoldamer-mediated manipulation of a pre-amyloid toxin10.1038/ncomms114122041-1723https://doaj.org/article/665697c8a506443f9f23cfe44a5d39832016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11412https://doaj.org/toc/2041-1723Intrinsically disordered proteins that form amyloid fibrils are hard to target with traditional therapeutic approaches. Here, the authors report on an oligoquinoline derivative that binds the human islet amyloid polypeptide, stabilising an alpha-helical structure that reduces its cellular toxicity.Sunil KumarMelissa BirolDiana E. SchlamadingerSlawomir P. WojcikElizabeth RhoadesAndrew D. MirankerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sunil Kumar Melissa Birol Diana E. Schlamadinger Slawomir P. Wojcik Elizabeth Rhoades Andrew D. Miranker Foldamer-mediated manipulation of a pre-amyloid toxin
description	Intrinsically disordered proteins that form amyloid fibrils are hard to target with traditional therapeutic approaches. Here, the authors report on an oligoquinoline derivative that binds the human islet amyloid polypeptide, stabilising an alpha-helical structure that reduces its cellular toxicity.
format	article
author	Sunil Kumar Melissa Birol Diana E. Schlamadinger Slawomir P. Wojcik Elizabeth Rhoades Andrew D. Miranker
author_facet	Sunil Kumar Melissa Birol Diana E. Schlamadinger Slawomir P. Wojcik Elizabeth Rhoades Andrew D. Miranker
author_sort	Sunil Kumar
title	Foldamer-mediated manipulation of a pre-amyloid toxin
title_short	Foldamer-mediated manipulation of a pre-amyloid toxin
title_full	Foldamer-mediated manipulation of a pre-amyloid toxin
title_fullStr	Foldamer-mediated manipulation of a pre-amyloid toxin
title_full_unstemmed	Foldamer-mediated manipulation of a pre-amyloid toxin
title_sort	foldamer-mediated manipulation of a pre-amyloid toxin
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/665697c8a506443f9f23cfe44a5d3983
work_keys_str_mv	AT sunilkumar foldamermediatedmanipulationofapreamyloidtoxin AT melissabirol foldamermediatedmanipulationofapreamyloidtoxin AT dianaeschlamadinger foldamermediatedmanipulationofapreamyloidtoxin AT slawomirpwojcik foldamermediatedmanipulationofapreamyloidtoxin AT elizabethrhoades foldamermediatedmanipulationofapreamyloidtoxin AT andrewdmiranker foldamermediatedmanipulationofapreamyloidtoxin
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Foldamer-mediated manipulation of a pre-amyloid toxin

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