Limited Utility of SIRS Criteria for Identifying Serious Infections in Febrile Young Infants

(1) Background: Young infants have a high risk of serious infection. The Systematic Inflammatory Response Syndrome (SIRS) criteria can be useful to identify both serious bacterial and viral infections. The aims of this study were to evaluate the diagnostic performance of the SIRS criteria for identi...

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Autores principales:	Osamu Nomura, Yoshihiko Morikawa, Takaaki Mori, Yusuke Hagiwara, Hiroshi Sakakibara, Yuho Horikoshi, Nobuaki Inoue
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	febrile young infants sepsis systematic inflammatory response syndrome serious infection Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/665cf81ebe874aaba6b7fb58918daade
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spelling	oai:doaj.org-article:665cf81ebe874aaba6b7fb58918daade2021-11-25T17:14:26ZLimited Utility of SIRS Criteria for Identifying Serious Infections in Febrile Young Infants10.3390/children81110032227-9067https://doaj.org/article/665cf81ebe874aaba6b7fb58918daade2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9067/8/11/1003https://doaj.org/toc/2227-9067(1) Background: Young infants have a high risk of serious infection. The Systematic Inflammatory Response Syndrome (SIRS) criteria can be useful to identify both serious bacterial and viral infections. The aims of this study were to evaluate the diagnostic performance of the SIRS criteria for identifying serious infections in febrile young infants and to identify potential clinical predictors of such infections. (2) Methods: We conducted this prospective cohort study including febrile young infants (aged < 90 days) seen at the emergency department with a body temperature of 38.0 °C or higher. We calculated the diagnostic performance parameters and conducted the logistic regression analysis to identify the predictors of serious infection. (3) Results: Of 311 enrolled patients, 36.7% (<i>n</i> = 114) met the SIRS criteria and 28.6% (<i>n</i> = 89) had a serious infection. The sensitivity, specificity, positive predictive value, and positive likelihood ratio of the SIRS criteria for serious infection was 45.9%, 69.4%, 43.5%, 71.4%, 1.5, and 0.8, respectively. Logistic regression showed that male gender, body temperature ≥ 38.5 °C, heart rate ≥ 178 bpm, and age ≤ 50 days were significant predictors. (4) Conclusions: The performance of the SIRS criteria for predicting serious infections among febrile young infants was poor.Osamu NomuraYoshihiko MorikawaTakaaki MoriYusuke HagiwaraHiroshi SakakibaraYuho HorikoshiNobuaki InoueMDPI AGarticlefebrile young infantssepsissystematic inflammatory response syndromeserious infectionPediatricsRJ1-570ENChildren, Vol 8, Iss 1003, p 1003 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	febrile young infants sepsis systematic inflammatory response syndrome serious infection Pediatrics RJ1-570
spellingShingle	febrile young infants sepsis systematic inflammatory response syndrome serious infection Pediatrics RJ1-570 Osamu Nomura Yoshihiko Morikawa Takaaki Mori Yusuke Hagiwara Hiroshi Sakakibara Yuho Horikoshi Nobuaki Inoue Limited Utility of SIRS Criteria for Identifying Serious Infections in Febrile Young Infants
description	(1) Background: Young infants have a high risk of serious infection. The Systematic Inflammatory Response Syndrome (SIRS) criteria can be useful to identify both serious bacterial and viral infections. The aims of this study were to evaluate the diagnostic performance of the SIRS criteria for identifying serious infections in febrile young infants and to identify potential clinical predictors of such infections. (2) Methods: We conducted this prospective cohort study including febrile young infants (aged < 90 days) seen at the emergency department with a body temperature of 38.0 °C or higher. We calculated the diagnostic performance parameters and conducted the logistic regression analysis to identify the predictors of serious infection. (3) Results: Of 311 enrolled patients, 36.7% (<i>n</i> = 114) met the SIRS criteria and 28.6% (<i>n</i> = 89) had a serious infection. The sensitivity, specificity, positive predictive value, and positive likelihood ratio of the SIRS criteria for serious infection was 45.9%, 69.4%, 43.5%, 71.4%, 1.5, and 0.8, respectively. Logistic regression showed that male gender, body temperature ≥ 38.5 °C, heart rate ≥ 178 bpm, and age ≤ 50 days were significant predictors. (4) Conclusions: The performance of the SIRS criteria for predicting serious infections among febrile young infants was poor.
format	article
author	Osamu Nomura Yoshihiko Morikawa Takaaki Mori Yusuke Hagiwara Hiroshi Sakakibara Yuho Horikoshi Nobuaki Inoue
author_facet	Osamu Nomura Yoshihiko Morikawa Takaaki Mori Yusuke Hagiwara Hiroshi Sakakibara Yuho Horikoshi Nobuaki Inoue
author_sort	Osamu Nomura
title	Limited Utility of SIRS Criteria for Identifying Serious Infections in Febrile Young Infants
title_short	Limited Utility of SIRS Criteria for Identifying Serious Infections in Febrile Young Infants
title_full	Limited Utility of SIRS Criteria for Identifying Serious Infections in Febrile Young Infants
title_fullStr	Limited Utility of SIRS Criteria for Identifying Serious Infections in Febrile Young Infants
title_full_unstemmed	Limited Utility of SIRS Criteria for Identifying Serious Infections in Febrile Young Infants
title_sort	limited utility of sirs criteria for identifying serious infections in febrile young infants
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/665cf81ebe874aaba6b7fb58918daade
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Limited Utility of SIRS Criteria for Identifying Serious Infections in Febrile Young Infants

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