Molecular architecture of black widow spider neurotoxins

The venom of Latrodectus spiders contains seven Latrotoxins (LaTXs), among them α-latrocrustatoxin (LCT) and δ- latroinsectotoxins δ-LIT. LaTXs bind to specific receptors on the surface of neuronal cells and target the molecular exocytosis machinery. Here, the authors present the cryo-EM structure o...

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Autores principales: Minghao Chen, Daniel Blum, Lena Engelhard, Stefan Raunser, Richard Wagner, Christos Gatsogiannis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/665db54f53c6489eba8074903eca63cd
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