Magnetically stimulated ciprofloxacin release from polymeric microspheres entrapping iron oxide nanoparticles

Sirinrath Sirivisoot,1 Benjamin S Harrison2 1Biological Engineering Program, Faculty of Engineering, King Mongkut’s University of Technology Thonburi, Bangkok, Thailand; 2Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Wake Forest University Health Science...

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Autores principales:	Sirivisoot S, Harrison BS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/665f1fd18f894cc4beee72d48514d1af
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spelling	oai:doaj.org-article:665f1fd18f894cc4beee72d48514d1af2021-12-02T03:55:34ZMagnetically stimulated ciprofloxacin release from polymeric microspheres entrapping iron oxide nanoparticles1178-2013https://doaj.org/article/665f1fd18f894cc4beee72d48514d1af2015-07-01T00:00:00Zhttp://www.dovepress.com/magnetically-stimulated-ciprofloxacin-release-fromnbsppolymeric-micros-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Sirinrath Sirivisoot,1 Benjamin S Harrison2 1Biological Engineering Program, Faculty of Engineering, King Mongkut’s University of Technology Thonburi, Bangkok, Thailand; 2Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA Abstract: To extend the external control capability of drug release, iron oxide nanoparticles (NPs) encapsulated into polymeric microspheres were used as magnetic media to stimulate drug release using an alternating magnetic field. Chemically synthesized iron oxide NPs, maghemite or hematite, and the antibiotic ciprofloxacin were encapsulated together within polycaprolactone microspheres. The polycaprolactone microspheres entrapping ciprofloxacin and magnetic NPs could be triggered for immediate drug release by magnetic stimulation at a maximum value of 40%. Moreover, the microspheres were cytocompatible with fibroblasts in vitro with a cell viability percentage of more than 100% relative to a nontreated control after 24 hours of culture. Macrophage cell cultures showed no signs of increased inflammatory responses after in vitro incubation for 56 hours. Treatment of Staphylococcus aureus with the magnetic microspheres under an alternating (isolating) magnetic field increased bacterial inhibition further after 2 days and 5 days in a broth inhibition assay. The findings of the present study indicate that iron oxide NPs, maghemite and hematite, can be used as media for stimulation by an external magnetic energy to activate immediate drug release. Keywords: antibacterial, maghemite, hematite, Staphylococcus aureusSirivisoot SHarrison BSDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 4447-4458 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Sirivisoot S Harrison BS Magnetically stimulated ciprofloxacin release from polymeric microspheres entrapping iron oxide nanoparticles
description	Sirinrath Sirivisoot,1 Benjamin S Harrison2 1Biological Engineering Program, Faculty of Engineering, King Mongkut’s University of Technology Thonburi, Bangkok, Thailand; 2Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA Abstract: To extend the external control capability of drug release, iron oxide nanoparticles (NPs) encapsulated into polymeric microspheres were used as magnetic media to stimulate drug release using an alternating magnetic field. Chemically synthesized iron oxide NPs, maghemite or hematite, and the antibiotic ciprofloxacin were encapsulated together within polycaprolactone microspheres. The polycaprolactone microspheres entrapping ciprofloxacin and magnetic NPs could be triggered for immediate drug release by magnetic stimulation at a maximum value of 40%. Moreover, the microspheres were cytocompatible with fibroblasts in vitro with a cell viability percentage of more than 100% relative to a nontreated control after 24 hours of culture. Macrophage cell cultures showed no signs of increased inflammatory responses after in vitro incubation for 56 hours. Treatment of Staphylococcus aureus with the magnetic microspheres under an alternating (isolating) magnetic field increased bacterial inhibition further after 2 days and 5 days in a broth inhibition assay. The findings of the present study indicate that iron oxide NPs, maghemite and hematite, can be used as media for stimulation by an external magnetic energy to activate immediate drug release. Keywords: antibacterial, maghemite, hematite, Staphylococcus aureus
format	article
author	Sirivisoot S Harrison BS
author_facet	Sirivisoot S Harrison BS
author_sort	Sirivisoot S
title	Magnetically stimulated ciprofloxacin release from polymeric microspheres entrapping iron oxide nanoparticles
title_short	Magnetically stimulated ciprofloxacin release from polymeric microspheres entrapping iron oxide nanoparticles
title_full	Magnetically stimulated ciprofloxacin release from polymeric microspheres entrapping iron oxide nanoparticles
title_fullStr	Magnetically stimulated ciprofloxacin release from polymeric microspheres entrapping iron oxide nanoparticles
title_full_unstemmed	Magnetically stimulated ciprofloxacin release from polymeric microspheres entrapping iron oxide nanoparticles
title_sort	magnetically stimulated ciprofloxacin release from polymeric microspheres entrapping iron oxide nanoparticles
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/665f1fd18f894cc4beee72d48514d1af
work_keys_str_mv	AT sirivisoots magneticallystimulatedciprofloxacinreleasefromnbsppolymericmicrospheresentrappingironoxidenanoparticles AT harrisonbs magneticallystimulatedciprofloxacinreleasefromnbsppolymericmicrospheresentrappingironoxidenanoparticles
_version_	1718401552700407808

Magnetically stimulated ciprofloxacin release from&nbsp;polymeric microspheres entrapping iron oxide nanoparticles

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Magnetically stimulated ciprofloxacin release from polymeric microspheres entrapping iron oxide nanoparticles