Dendrimers bind antioxidant polyphenols and cisplatin drug.

Synthetic polymers of a specific shape and size play major role in drug delivery systems. Dendrimers are unique synthetic macromolecules of nanometer dimensions with a highly branched structure and globular shape with potential applications in gene and drug delivery. We examine the interaction of se...

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Autores principales:	Amine Abderrezak, Philippe Bourassa, Jean-Sebastian Mandeville, Reza Sedaghat-Herati, Heidar-Ali Tajmir-Riahi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/665f53168cd74b278d4fe7228a2a96be
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spelling	oai:doaj.org-article:665f53168cd74b278d4fe7228a2a96be2021-11-18T07:25:19ZDendrimers bind antioxidant polyphenols and cisplatin drug.1932-620310.1371/journal.pone.0033102https://doaj.org/article/665f53168cd74b278d4fe7228a2a96be2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22427960/?tool=EBIhttps://doaj.org/toc/1932-6203Synthetic polymers of a specific shape and size play major role in drug delivery systems. Dendrimers are unique synthetic macromolecules of nanometer dimensions with a highly branched structure and globular shape with potential applications in gene and drug delivery. We examine the interaction of several dendrimers of different compositions mPEG-PAMAM (G3), mPEG-PAMAM (G4) and PAMAM (G4) with hydrophilic and hydrophobic drugs cisplatin, resveratrol, genistein and curcumin at physiological conditions. FTIR and UV-visible spectroscopic methods as well as molecular modeling were used to analyse drug binding mode, the binding constant and the effects of drug complexation on dendrimer stability and conformation. Structural analysis showed that cisplatin binds dendrimers in hydrophilic mode via Pt cation and polymer terminal NH(2) groups, while curcumin, genistein and resveratrol are located mainly in the cavities binding through both hydrophobic and hydrophilic contacts. The overall binding constants of durg-dendrimers are ranging from 10(2) M(-1) to 10(3) M(-1). The affinity of dendrimer binding was PAMAM-G4>mPEG-PAMAM-G4>mPEG-PAMAM-G3, while the order of drug-polymer stability was curcumin>cisplatin>genistein>resveratrol. Molecular modeling showed larger stability for genisten-PAMAM-G4 (ΔG = -4.75 kcal/mol) than curcumin-PAMAM-G4 ((ΔG = -4.53 kcal/mol) and resveratrol-PAMAM-G4 ((ΔG = -4.39 kcal/mol). Dendrimers might act as carriers to transport hydrophobic and hydrophilic drugs.Amine AbderrezakPhilippe BourassaJean-Sebastian MandevilleReza Sedaghat-HeratiHeidar-Ali Tajmir-RiahiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e33102 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amine Abderrezak Philippe Bourassa Jean-Sebastian Mandeville Reza Sedaghat-Herati Heidar-Ali Tajmir-Riahi Dendrimers bind antioxidant polyphenols and cisplatin drug.
description	Synthetic polymers of a specific shape and size play major role in drug delivery systems. Dendrimers are unique synthetic macromolecules of nanometer dimensions with a highly branched structure and globular shape with potential applications in gene and drug delivery. We examine the interaction of several dendrimers of different compositions mPEG-PAMAM (G3), mPEG-PAMAM (G4) and PAMAM (G4) with hydrophilic and hydrophobic drugs cisplatin, resveratrol, genistein and curcumin at physiological conditions. FTIR and UV-visible spectroscopic methods as well as molecular modeling were used to analyse drug binding mode, the binding constant and the effects of drug complexation on dendrimer stability and conformation. Structural analysis showed that cisplatin binds dendrimers in hydrophilic mode via Pt cation and polymer terminal NH(2) groups, while curcumin, genistein and resveratrol are located mainly in the cavities binding through both hydrophobic and hydrophilic contacts. The overall binding constants of durg-dendrimers are ranging from 10(2) M(-1) to 10(3) M(-1). The affinity of dendrimer binding was PAMAM-G4>mPEG-PAMAM-G4>mPEG-PAMAM-G3, while the order of drug-polymer stability was curcumin>cisplatin>genistein>resveratrol. Molecular modeling showed larger stability for genisten-PAMAM-G4 (ΔG = -4.75 kcal/mol) than curcumin-PAMAM-G4 ((ΔG = -4.53 kcal/mol) and resveratrol-PAMAM-G4 ((ΔG = -4.39 kcal/mol). Dendrimers might act as carriers to transport hydrophobic and hydrophilic drugs.
format	article
author	Amine Abderrezak Philippe Bourassa Jean-Sebastian Mandeville Reza Sedaghat-Herati Heidar-Ali Tajmir-Riahi
author_facet	Amine Abderrezak Philippe Bourassa Jean-Sebastian Mandeville Reza Sedaghat-Herati Heidar-Ali Tajmir-Riahi
author_sort	Amine Abderrezak
title	Dendrimers bind antioxidant polyphenols and cisplatin drug.
title_short	Dendrimers bind antioxidant polyphenols and cisplatin drug.
title_full	Dendrimers bind antioxidant polyphenols and cisplatin drug.
title_fullStr	Dendrimers bind antioxidant polyphenols and cisplatin drug.
title_full_unstemmed	Dendrimers bind antioxidant polyphenols and cisplatin drug.
title_sort	dendrimers bind antioxidant polyphenols and cisplatin drug.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/665f53168cd74b278d4fe7228a2a96be
work_keys_str_mv	AT amineabderrezak dendrimersbindantioxidantpolyphenolsandcisplatindrug AT philippebourassa dendrimersbindantioxidantpolyphenolsandcisplatindrug AT jeansebastianmandeville dendrimersbindantioxidantpolyphenolsandcisplatindrug AT rezasedaghatherati dendrimersbindantioxidantpolyphenolsandcisplatindrug AT heidaralitajmirriahi dendrimersbindantioxidantpolyphenolsandcisplatindrug
_version_	1718423478561931264

Dendrimers bind antioxidant polyphenols and cisplatin drug.

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