Force of infection: a determinant of vaccine efficacy?

Abstract Vaccine efficacy (VE) can vary in different settings. Of the many proposed setting-dependent determinants of VE, force of infection (FoI) stands out as one of the most direct, proximate, and actionable. As highlighted by the COVID-19 pandemic, modifying FoI through non-pharmaceutical interv...

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Autor principal:	David C. Kaslow
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/66616f8e1eff4f78914611366ca5864a
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spelling	oai:doaj.org-article:66616f8e1eff4f78914611366ca5864a2021-12-02T14:30:51ZForce of infection: a determinant of vaccine efficacy?10.1038/s41541-021-00316-52059-0105https://doaj.org/article/66616f8e1eff4f78914611366ca5864a2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41541-021-00316-5https://doaj.org/toc/2059-0105Abstract Vaccine efficacy (VE) can vary in different settings. Of the many proposed setting-dependent determinants of VE, force of infection (FoI) stands out as one of the most direct, proximate, and actionable. As highlighted by the COVID-19 pandemic, modifying FoI through non-pharmaceutical interventions (NPIs) use can significantly contribute to controlling transmission and reducing disease incidence and severity absent highly effective pharmaceutical interventions, such as vaccines. Given that NPIs reduce the FoI, the question arises as to if and to what degree FoI, and by extension NPIs, can modify VE, and more practically, as vaccines become available for a pathogen, whether and which NPIs should continue to be used in conjunction with vaccines to optimize controlling transmission and reducing disease incidence and severity.David C. KaslowNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 David C. Kaslow Force of infection: a determinant of vaccine efficacy?
description	Abstract Vaccine efficacy (VE) can vary in different settings. Of the many proposed setting-dependent determinants of VE, force of infection (FoI) stands out as one of the most direct, proximate, and actionable. As highlighted by the COVID-19 pandemic, modifying FoI through non-pharmaceutical interventions (NPIs) use can significantly contribute to controlling transmission and reducing disease incidence and severity absent highly effective pharmaceutical interventions, such as vaccines. Given that NPIs reduce the FoI, the question arises as to if and to what degree FoI, and by extension NPIs, can modify VE, and more practically, as vaccines become available for a pathogen, whether and which NPIs should continue to be used in conjunction with vaccines to optimize controlling transmission and reducing disease incidence and severity.
format	article
author	David C. Kaslow
author_facet	David C. Kaslow
author_sort	David C. Kaslow
title	Force of infection: a determinant of vaccine efficacy?
title_short	Force of infection: a determinant of vaccine efficacy?
title_full	Force of infection: a determinant of vaccine efficacy?
title_fullStr	Force of infection: a determinant of vaccine efficacy?
title_full_unstemmed	Force of infection: a determinant of vaccine efficacy?
title_sort	force of infection: a determinant of vaccine efficacy?
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/66616f8e1eff4f78914611366ca5864a
work_keys_str_mv	AT davidckaslow forceofinfectionadeterminantofvaccineefficacy
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Force of infection: a determinant of vaccine efficacy?

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