Reliable intraocular pressure measurement using automated radio-wave telemetry

Eleftherios I Paschalis,* Fabiano Cade,* Samir Melki, Louis R Pasquale, Claes H Dohlman, Joseph B CiolinoMassachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA*These authors contributed equally to this workPurpose: To present an autonomous intraocular pressure (IOP) measuremen...

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Autores principales:	Paschalis EI, Cade F, Melki S, Pasquale LR, Dohlman CH, Ciolino JB
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/666181b756c14fb48d7b7e51b410c656
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spelling	oai:doaj.org-article:666181b756c14fb48d7b7e51b410c6562021-12-02T08:01:54ZReliable intraocular pressure measurement using automated radio-wave telemetry1177-5483https://doaj.org/article/666181b756c14fb48d7b7e51b410c6562014-01-01T00:00:00Zhttp://www.dovepress.com/reliable-intraocular-pressure-measurement-using-automated-radio-wave-t-a15436https://doaj.org/toc/1177-5483 Eleftherios I Paschalis,* Fabiano Cade,* Samir Melki, Louis R Pasquale, Claes H Dohlman, Joseph B CiolinoMassachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA*These authors contributed equally to this workPurpose: To present an autonomous intraocular pressure (IOP) measurement technique using a wireless implantable transducer (WIT) and a motion sensor.Methods: The WIT optical aid was implanted within the ciliary sulcus of a normotensive rabbit eye after extracapsular clear lens extraction. An autonomous wireless data system (AWDS) comprising of a WIT and an external antenna aided by a motion sensor provided continuous IOP readings. The sensitivity of the technique was determined by the ability to detect IOP changes resulting from the administration of latanoprost 0.005% or dorzolamide 2%, while the reliability was determined by the agreement between baseline and vehicle (saline) IOP.Results: On average, 12 diurnal and 205 nocturnal IOP measurements were performed with latanoprost, and 26 diurnal and 205 nocturnal measurements with dorzolamide. No difference was found between mean baseline IOP (13.08±2.2 mmHg) and mean vehicle IOP (13.27±2.1 mmHg) (P=0.45), suggesting good measurement reliability. Both antiglaucoma medications caused significant IOP reduction compared to baseline; latanoprost reduced mean IOP by 10% (1.3±3.54 mmHg; P<0.001), and dorzolamide by 5% (0.62±2.22 mmHg; P<0.001). Use of latanoprost resulted in an overall twofold higher IOP reduction compared to dorzolamide (P<0.001). Repeatability was ±1.8 mmHg, assessed by the variability of consecutive IOP measurements performed in a short period of time (≤1 minute), during which the IOP is not expected to change.Conclusion: IOP measurements in conscious rabbits obtained without the need for human interactions using the AWDS are feasible and provide reproducible results.Keywords: IOP, pressure transducer, wireless, MEMS, implant, intraocularPaschalis EICade FMelki SPasquale LRDohlman CHCiolino JBDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 177-185 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Paschalis EI Cade F Melki S Pasquale LR Dohlman CH Ciolino JB Reliable intraocular pressure measurement using automated radio-wave telemetry
description	Eleftherios I Paschalis,* Fabiano Cade,* Samir Melki, Louis R Pasquale, Claes H Dohlman, Joseph B CiolinoMassachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA*These authors contributed equally to this workPurpose: To present an autonomous intraocular pressure (IOP) measurement technique using a wireless implantable transducer (WIT) and a motion sensor.Methods: The WIT optical aid was implanted within the ciliary sulcus of a normotensive rabbit eye after extracapsular clear lens extraction. An autonomous wireless data system (AWDS) comprising of a WIT and an external antenna aided by a motion sensor provided continuous IOP readings. The sensitivity of the technique was determined by the ability to detect IOP changes resulting from the administration of latanoprost 0.005% or dorzolamide 2%, while the reliability was determined by the agreement between baseline and vehicle (saline) IOP.Results: On average, 12 diurnal and 205 nocturnal IOP measurements were performed with latanoprost, and 26 diurnal and 205 nocturnal measurements with dorzolamide. No difference was found between mean baseline IOP (13.08±2.2 mmHg) and mean vehicle IOP (13.27±2.1 mmHg) (P=0.45), suggesting good measurement reliability. Both antiglaucoma medications caused significant IOP reduction compared to baseline; latanoprost reduced mean IOP by 10% (1.3±3.54 mmHg; P<0.001), and dorzolamide by 5% (0.62±2.22 mmHg; P<0.001). Use of latanoprost resulted in an overall twofold higher IOP reduction compared to dorzolamide (P<0.001). Repeatability was ±1.8 mmHg, assessed by the variability of consecutive IOP measurements performed in a short period of time (≤1 minute), during which the IOP is not expected to change.Conclusion: IOP measurements in conscious rabbits obtained without the need for human interactions using the AWDS are feasible and provide reproducible results.Keywords: IOP, pressure transducer, wireless, MEMS, implant, intraocular
format	article
author	Paschalis EI Cade F Melki S Pasquale LR Dohlman CH Ciolino JB
author_facet	Paschalis EI Cade F Melki S Pasquale LR Dohlman CH Ciolino JB
author_sort	Paschalis EI
title	Reliable intraocular pressure measurement using automated radio-wave telemetry
title_short	Reliable intraocular pressure measurement using automated radio-wave telemetry
title_full	Reliable intraocular pressure measurement using automated radio-wave telemetry
title_fullStr	Reliable intraocular pressure measurement using automated radio-wave telemetry
title_full_unstemmed	Reliable intraocular pressure measurement using automated radio-wave telemetry
title_sort	reliable intraocular pressure measurement using automated radio-wave telemetry
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/666181b756c14fb48d7b7e51b410c656
work_keys_str_mv	AT paschalisei reliableintraocularpressuremeasurementusingautomatedradiowavetelemetry AT cadef reliableintraocularpressuremeasurementusingautomatedradiowavetelemetry AT melkis reliableintraocularpressuremeasurementusingautomatedradiowavetelemetry AT pasqualelr reliableintraocularpressuremeasurementusingautomatedradiowavetelemetry AT dohlmanch reliableintraocularpressuremeasurementusingautomatedradiowavetelemetry AT ciolinojb reliableintraocularpressuremeasurementusingautomatedradiowavetelemetry
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Reliable intraocular pressure measurement using automated radio-wave telemetry

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