Spatial reorganization of putaminal dopamine D2-like receptors in cranial and hand dystonia.

The putamen has a somatotopic organization of neurons identified by correspondence of firing rates with selected body part movements, as well as by complex, but organized, differential cortical projections onto putamen. In isolated focal dystonia, whole putaminal binding of dopamine D2-like receptor...

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Autores principales:	Kevin J Black, Abraham Z Snyder, Jonathan W Mink, Veeral N Tolia, Fredy J Revilla, Stephen M Moerlein, Joel S Perlmutter
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/666194a37b3e40908b5c92274be195f4
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spelling	oai:doaj.org-article:666194a37b3e40908b5c92274be195f42021-11-18T08:33:11ZSpatial reorganization of putaminal dopamine D2-like receptors in cranial and hand dystonia.1932-620310.1371/journal.pone.0088121https://doaj.org/article/666194a37b3e40908b5c92274be195f42014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24520350/?tool=EBIhttps://doaj.org/toc/1932-6203The putamen has a somatotopic organization of neurons identified by correspondence of firing rates with selected body part movements, as well as by complex, but organized, differential cortical projections onto putamen. In isolated focal dystonia, whole putaminal binding of dopamine D2-like receptor radioligands is quantitatively decreased, but it has not been known whether selected parts of the putamen are differentially affected depending upon the body part affected by dystonia. The radioligand [(18)F]spiperone binds predominantly to D2-like receptors in striatum. We hypothesized that the spatial location of [(18)F]spiperone binding within the putamen would differ in patients with dystonia limited to the hand versus the face, and we tested that hypothesis using positron emission tomography and magnetic resonance imaging. To address statistical and methodological concerns, we chose a straightforward but robust image analysis method. An automated algorithm located the peak location of [(18)F]spiperone binding within the striatum, relative to a brain atlas, in each of 14 patients with cranial dystonia and 8 patients with hand dystonia. The mean (left and right) \|x\|, y, and z coordinates of peak striatal binding for each patient were compared between groups by t test. The location of peak [(18)F]spiperone binding within the putamen differed significantly between groups (cranial dystonia z<hand dystonia z, p = 0.016). We conclude that in isolated focal dystonia, dopamine D2-like receptors are distributed differently in the putamen depending on the body part manifesting dystonia.Kevin J BlackAbraham Z SnyderJonathan W MinkVeeral N ToliaFredy J RevillaStephen M MoerleinJoel S PerlmutterPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e88121 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kevin J Black Abraham Z Snyder Jonathan W Mink Veeral N Tolia Fredy J Revilla Stephen M Moerlein Joel S Perlmutter Spatial reorganization of putaminal dopamine D2-like receptors in cranial and hand dystonia.
description	The putamen has a somatotopic organization of neurons identified by correspondence of firing rates with selected body part movements, as well as by complex, but organized, differential cortical projections onto putamen. In isolated focal dystonia, whole putaminal binding of dopamine D2-like receptor radioligands is quantitatively decreased, but it has not been known whether selected parts of the putamen are differentially affected depending upon the body part affected by dystonia. The radioligand [(18)F]spiperone binds predominantly to D2-like receptors in striatum. We hypothesized that the spatial location of [(18)F]spiperone binding within the putamen would differ in patients with dystonia limited to the hand versus the face, and we tested that hypothesis using positron emission tomography and magnetic resonance imaging. To address statistical and methodological concerns, we chose a straightforward but robust image analysis method. An automated algorithm located the peak location of [(18)F]spiperone binding within the striatum, relative to a brain atlas, in each of 14 patients with cranial dystonia and 8 patients with hand dystonia. The mean (left and right) \|x\|, y, and z coordinates of peak striatal binding for each patient were compared between groups by t test. The location of peak [(18)F]spiperone binding within the putamen differed significantly between groups (cranial dystonia z<hand dystonia z, p = 0.016). We conclude that in isolated focal dystonia, dopamine D2-like receptors are distributed differently in the putamen depending on the body part manifesting dystonia.
format	article
author	Kevin J Black Abraham Z Snyder Jonathan W Mink Veeral N Tolia Fredy J Revilla Stephen M Moerlein Joel S Perlmutter
author_facet	Kevin J Black Abraham Z Snyder Jonathan W Mink Veeral N Tolia Fredy J Revilla Stephen M Moerlein Joel S Perlmutter
author_sort	Kevin J Black
title	Spatial reorganization of putaminal dopamine D2-like receptors in cranial and hand dystonia.
title_short	Spatial reorganization of putaminal dopamine D2-like receptors in cranial and hand dystonia.
title_full	Spatial reorganization of putaminal dopamine D2-like receptors in cranial and hand dystonia.
title_fullStr	Spatial reorganization of putaminal dopamine D2-like receptors in cranial and hand dystonia.
title_full_unstemmed	Spatial reorganization of putaminal dopamine D2-like receptors in cranial and hand dystonia.
title_sort	spatial reorganization of putaminal dopamine d2-like receptors in cranial and hand dystonia.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/666194a37b3e40908b5c92274be195f4
work_keys_str_mv	AT kevinjblack spatialreorganizationofputaminaldopamined2likereceptorsincranialandhanddystonia AT abrahamzsnyder spatialreorganizationofputaminaldopamined2likereceptorsincranialandhanddystonia AT jonathanwmink spatialreorganizationofputaminaldopamined2likereceptorsincranialandhanddystonia AT veeralntolia spatialreorganizationofputaminaldopamined2likereceptorsincranialandhanddystonia AT fredyjrevilla spatialreorganizationofputaminaldopamined2likereceptorsincranialandhanddystonia AT stephenmmoerlein spatialreorganizationofputaminaldopamined2likereceptorsincranialandhanddystonia AT joelsperlmutter spatialreorganizationofputaminaldopamined2likereceptorsincranialandhanddystonia
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Spatial reorganization of putaminal dopamine D2-like receptors in cranial and hand dystonia.

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