Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma

Olfactory neuroblastoma (ONB) is a rare malignant tumor whose genetic basis is poorly understood. Here the authors identify recurrent deletions involving dystrophin in the majority of ONB patient tumors examined.

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Autores principales: Gary L. Gallia, Ming Zhang, Yi Ning, Michael C. Haffner, Denise Batista, Zev A. Binder, Justin A. Bishop, Christine L. Hann, Ralph H. Hruban, Masaru Ishii, Alison P. Klein, Douglas D. Reh, Lisa M. Rooper, Vafi Salmasi, Rafael J. Tamargo, Qing Wang, Tara Williamson, Tianna Zhao, Ying Zou, Alan K. Meeker, Nishant Agrawal, Bert Vogelstein, Kenneth W. Kinzler, Nickolas Papadopoulos, Chetan Bettegowda
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/666203899eb144b58109b82017f4bbe7
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Sumario:Olfactory neuroblastoma (ONB) is a rare malignant tumor whose genetic basis is poorly understood. Here the authors identify recurrent deletions involving dystrophin in the majority of ONB patient tumors examined.