Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration

Microglia perform important supporting roles for neurons in the brain. Here, the authors show that microglia clear neuron-derived α-synuclein through selective autophagy (synucleinphagy) to prevent accumulation of misfolded α-synuclein and subsequent neurodegeneration in a mouse model of disease.

Guardado en:

Detalles Bibliográficos
Autores principales:	Insup Choi, Yuanxi Zhang, Steven P. Seegobin, Mathilde Pruvost, Qian Wang, Kerry Purtell, Bin Zhang, Zhenyu Yue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/666741e7ee464c8c913aa49d57227aa6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:666741e7ee464c8c913aa49d57227aa6
record_format	dspace
spelling	oai:doaj.org-article:666741e7ee464c8c913aa49d57227aa62021-12-02T14:42:15ZMicroglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration10.1038/s41467-020-15119-w2041-1723https://doaj.org/article/666741e7ee464c8c913aa49d57227aa62020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15119-whttps://doaj.org/toc/2041-1723Microglia perform important supporting roles for neurons in the brain. Here, the authors show that microglia clear neuron-derived α-synuclein through selective autophagy (synucleinphagy) to prevent accumulation of misfolded α-synuclein and subsequent neurodegeneration in a mouse model of disease.Insup ChoiYuanxi ZhangSteven P. SeegobinMathilde PruvostQian WangKerry PurtellBin ZhangZhenyu YueNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Insup Choi Yuanxi Zhang Steven P. Seegobin Mathilde Pruvost Qian Wang Kerry Purtell Bin Zhang Zhenyu Yue Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration
description	Microglia perform important supporting roles for neurons in the brain. Here, the authors show that microglia clear neuron-derived α-synuclein through selective autophagy (synucleinphagy) to prevent accumulation of misfolded α-synuclein and subsequent neurodegeneration in a mouse model of disease.
format	article
author	Insup Choi Yuanxi Zhang Steven P. Seegobin Mathilde Pruvost Qian Wang Kerry Purtell Bin Zhang Zhenyu Yue
author_facet	Insup Choi Yuanxi Zhang Steven P. Seegobin Mathilde Pruvost Qian Wang Kerry Purtell Bin Zhang Zhenyu Yue
author_sort	Insup Choi
title	Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration
title_short	Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration
title_full	Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration
title_fullStr	Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration
title_full_unstemmed	Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration
title_sort	microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/666741e7ee464c8c913aa49d57227aa6
work_keys_str_mv	AT insupchoi microgliaclearneuronreleasedasynucleinviaselectiveautophagyandpreventneurodegeneration AT yuanxizhang microgliaclearneuronreleasedasynucleinviaselectiveautophagyandpreventneurodegeneration AT stevenpseegobin microgliaclearneuronreleasedasynucleinviaselectiveautophagyandpreventneurodegeneration AT mathildepruvost microgliaclearneuronreleasedasynucleinviaselectiveautophagyandpreventneurodegeneration AT qianwang microgliaclearneuronreleasedasynucleinviaselectiveautophagyandpreventneurodegeneration AT kerrypurtell microgliaclearneuronreleasedasynucleinviaselectiveautophagyandpreventneurodegeneration AT binzhang microgliaclearneuronreleasedasynucleinviaselectiveautophagyandpreventneurodegeneration AT zhenyuyue microgliaclearneuronreleasedasynucleinviaselectiveautophagyandpreventneurodegeneration
_version_	1718389754518568960

Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration

Ejemplares similares