Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster

Mitochondrial dynamics change during ageing, with larger mitochondria and altered protein import in older animals. Here the authors show that Dosmit protein mediates mitochondrial morphology with Rab32 by inducing double-membraned vesicles that regulate protein trafficking into mitochondria.

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Autores principales:	Po-Lin Chen, Kai-Ting Huang, Chu-Ya Cheng, Jian-Chiuan Li, Hsiao-Yen Chan, Tzu-Yang Lin, Matthew P. Su, Wei-Yuan Yang, Henry C. Chang, Horng-Dar Wang, Chun-Hong Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/666dd2760252480d98caf0dd4c44a027
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spelling	oai:doaj.org-article:666dd2760252480d98caf0dd4c44a0272021-12-02T15:52:52ZVesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster10.1038/s41467-020-16335-02041-1723https://doaj.org/article/666dd2760252480d98caf0dd4c44a0272020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16335-0https://doaj.org/toc/2041-1723Mitochondrial dynamics change during ageing, with larger mitochondria and altered protein import in older animals. Here the authors show that Dosmit protein mediates mitochondrial morphology with Rab32 by inducing double-membraned vesicles that regulate protein trafficking into mitochondria.Po-Lin ChenKai-Ting HuangChu-Ya ChengJian-Chiuan LiHsiao-Yen ChanTzu-Yang LinMatthew P. SuWei-Yuan YangHenry C. ChangHorng-Dar WangChun-Hong ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Po-Lin Chen Kai-Ting Huang Chu-Ya Cheng Jian-Chiuan Li Hsiao-Yen Chan Tzu-Yang Lin Matthew P. Su Wei-Yuan Yang Henry C. Chang Horng-Dar Wang Chun-Hong Chen Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster
description	Mitochondrial dynamics change during ageing, with larger mitochondria and altered protein import in older animals. Here the authors show that Dosmit protein mediates mitochondrial morphology with Rab32 by inducing double-membraned vesicles that regulate protein trafficking into mitochondria.
format	article
author	Po-Lin Chen Kai-Ting Huang Chu-Ya Cheng Jian-Chiuan Li Hsiao-Yen Chan Tzu-Yang Lin Matthew P. Su Wei-Yuan Yang Henry C. Chang Horng-Dar Wang Chun-Hong Chen
author_facet	Po-Lin Chen Kai-Ting Huang Chu-Ya Cheng Jian-Chiuan Li Hsiao-Yen Chan Tzu-Yang Lin Matthew P. Su Wei-Yuan Yang Henry C. Chang Horng-Dar Wang Chun-Hong Chen
author_sort	Po-Lin Chen
title	Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster
title_short	Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster
title_full	Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster
title_fullStr	Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster
title_full_unstemmed	Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster
title_sort	vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in drosophila melanogaster
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/666dd2760252480d98caf0dd4c44a027
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Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster

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