Comparison of the cytotoxic effects of bulk and nanosized CeO2 on lymphocyte cells

Cerium(IV) oxide (CeO2) is widely used in industrial fields such as biomedical, glass, electronics, automotive, and pharmacology. In this study, the cytotoxic effects on human peripheral blood cultures of two forms of cerium(IV) oxide with different particle sizes (Bulk-sized Cerium(IV) oxide: BC an...

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Autor principal:	Giray Buğra AKBABA
Formato:	article
Lenguaje:	EN
Publicado:	Turkish Chemical Society 2021
Materias:	cerium (iv) oxide biomaterial cytotoxicity mtt assay lymphocyte nanoparticle Chemistry QD1-999
Acceso en línea:	https://doi.org/10.18596/jotcsa.974814 https://doaj.org/article/667306d1ac6e45dbb30e4945eecb5a38
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spelling	oai:doaj.org-article:667306d1ac6e45dbb30e4945eecb5a382021-11-20T09:50:02Z Comparison of the cytotoxic effects of bulk and nanosized CeO2 on lymphocyte cells https://doi.org/10.18596/jotcsa.9748142149-0120https://doaj.org/article/667306d1ac6e45dbb30e4945eecb5a382021-11-01T00:00:00Zhttps://dergipark.org.tr/tr/pub/jotcsa/issue/64621/974814https://doaj.org/toc/2149-0120Cerium(IV) oxide (CeO2) is widely used in industrial fields such as biomedical, glass, electronics, automotive, and pharmacology. In this study, the cytotoxic effects on human peripheral blood cultures of two forms of cerium(IV) oxide with different particle sizes (Bulk-sized Cerium(IV) oxide: BC and Nano-sized Cerium(IV) oxide: NC) in concentrations range of 0.001-200 ppm were investigated. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay were used to determine the cytotoxicity of these forms. According to the test results, it was determined that both forms caused severe cytotoxicity at all concentrations studied. It was observed that cytotoxicity increased with increasing concentration. NCs are more toxic at all concentrations except 100 and 200 ppm concentrations.Giray Buğra AKBABATurkish Chemical Societyarticlecerium (iv) oxidebiomaterialcytotoxicitymtt assaylymphocytenanoparticleChemistryQD1-999ENJournal of the Turkish Chemical Society, Section A: Chemistry, Vol 8, Iss 4, Pp 1145 -1152 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cerium (iv) oxide biomaterial cytotoxicity mtt assay lymphocyte nanoparticle Chemistry QD1-999
spellingShingle	cerium (iv) oxide biomaterial cytotoxicity mtt assay lymphocyte nanoparticle Chemistry QD1-999 Giray Buğra AKBABA Comparison of the cytotoxic effects of bulk and nanosized CeO2 on lymphocyte cells
description	Cerium(IV) oxide (CeO2) is widely used in industrial fields such as biomedical, glass, electronics, automotive, and pharmacology. In this study, the cytotoxic effects on human peripheral blood cultures of two forms of cerium(IV) oxide with different particle sizes (Bulk-sized Cerium(IV) oxide: BC and Nano-sized Cerium(IV) oxide: NC) in concentrations range of 0.001-200 ppm were investigated. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay were used to determine the cytotoxicity of these forms. According to the test results, it was determined that both forms caused severe cytotoxicity at all concentrations studied. It was observed that cytotoxicity increased with increasing concentration. NCs are more toxic at all concentrations except 100 and 200 ppm concentrations.
format	article
author	Giray Buğra AKBABA
author_facet	Giray Buğra AKBABA
author_sort	Giray Buğra AKBABA
title	Comparison of the cytotoxic effects of bulk and nanosized CeO2 on lymphocyte cells
title_short	Comparison of the cytotoxic effects of bulk and nanosized CeO2 on lymphocyte cells
title_full	Comparison of the cytotoxic effects of bulk and nanosized CeO2 on lymphocyte cells
title_fullStr	Comparison of the cytotoxic effects of bulk and nanosized CeO2 on lymphocyte cells
title_full_unstemmed	Comparison of the cytotoxic effects of bulk and nanosized CeO2 on lymphocyte cells
title_sort	comparison of the cytotoxic effects of bulk and nanosized ceo2 on lymphocyte cells
publisher	Turkish Chemical Society
publishDate	2021
url	https://doi.org/10.18596/jotcsa.974814 https://doaj.org/article/667306d1ac6e45dbb30e4945eecb5a38
work_keys_str_mv	AT giraybugraakbaba comparisonofthecytotoxiceffectsofbulkandnanosizedceo2onlymphocytecells
_version_	1718419429141774336

Comparison of the cytotoxic effects of bulk and nanosized CeO2 on lymphocyte cells

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