Research progress on the mechanism of orexin in pain regulation in different brain regions

Orexin is a neuropeptide that is primarily synthesized and secreted by the lateral hypothalamus (LH) and includes two substances derived from the same precursor (orexin A [OXA] and orexin B [OXB]). Studies have shown that orexin is not only involved in the regulation of eating, the sleep–wake cycle,...

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Autores principales:	Kang Xianhui, Tang Hongli, Liu Yao, Yuan Yan, Wang Mi
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	orexins orexin a pain regulation orexin receptors acute pain Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/66738fcdd6c347d59f13d577b3ac3f0d
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id	oai:doaj.org-article:66738fcdd6c347d59f13d577b3ac3f0d
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spelling	oai:doaj.org-article:66738fcdd6c347d59f13d577b3ac3f0d2021-12-05T14:10:40ZResearch progress on the mechanism of orexin in pain regulation in different brain regions2391-541210.1515/biol-2021-0001https://doaj.org/article/66738fcdd6c347d59f13d577b3ac3f0d2021-01-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0001https://doaj.org/toc/2391-5412Orexin is a neuropeptide that is primarily synthesized and secreted by the lateral hypothalamus (LH) and includes two substances derived from the same precursor (orexin A [OXA] and orexin B [OXB]). Studies have shown that orexin is not only involved in the regulation of eating, the sleep–wake cycle, and energy metabolism, but also closely associated with various physiological functions, such as cardiovascular control, reproduction, stress, reward, addiction, and the modulation of pain transmission. At present, studies that have been performed both domestically and abroad have confirmed that orexin and its receptors are closely associated with pain regulation. In this article, the research progress on acute pain regulation involving orexin is reviewed.Kang XianhuiTang HongliLiu YaoYuan YanWang MiDe Gruyterarticleorexinsorexin apain regulationorexin receptorsacute painBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 46-52 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	orexins orexin a pain regulation orexin receptors acute pain Biology (General) QH301-705.5
spellingShingle	orexins orexin a pain regulation orexin receptors acute pain Biology (General) QH301-705.5 Kang Xianhui Tang Hongli Liu Yao Yuan Yan Wang Mi Research progress on the mechanism of orexin in pain regulation in different brain regions
description	Orexin is a neuropeptide that is primarily synthesized and secreted by the lateral hypothalamus (LH) and includes two substances derived from the same precursor (orexin A [OXA] and orexin B [OXB]). Studies have shown that orexin is not only involved in the regulation of eating, the sleep–wake cycle, and energy metabolism, but also closely associated with various physiological functions, such as cardiovascular control, reproduction, stress, reward, addiction, and the modulation of pain transmission. At present, studies that have been performed both domestically and abroad have confirmed that orexin and its receptors are closely associated with pain regulation. In this article, the research progress on acute pain regulation involving orexin is reviewed.
format	article
author	Kang Xianhui Tang Hongli Liu Yao Yuan Yan Wang Mi
author_facet	Kang Xianhui Tang Hongli Liu Yao Yuan Yan Wang Mi
author_sort	Kang Xianhui
title	Research progress on the mechanism of orexin in pain regulation in different brain regions
title_short	Research progress on the mechanism of orexin in pain regulation in different brain regions
title_full	Research progress on the mechanism of orexin in pain regulation in different brain regions
title_fullStr	Research progress on the mechanism of orexin in pain regulation in different brain regions
title_full_unstemmed	Research progress on the mechanism of orexin in pain regulation in different brain regions
title_sort	research progress on the mechanism of orexin in pain regulation in different brain regions
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/66738fcdd6c347d59f13d577b3ac3f0d
work_keys_str_mv	AT kangxianhui researchprogressonthemechanismoforexininpainregulationindifferentbrainregions AT tanghongli researchprogressonthemechanismoforexininpainregulationindifferentbrainregions AT liuyao researchprogressonthemechanismoforexininpainregulationindifferentbrainregions AT yuanyan researchprogressonthemechanismoforexininpainregulationindifferentbrainregions AT wangmi researchprogressonthemechanismoforexininpainregulationindifferentbrainregions
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Research progress on the mechanism of orexin in pain regulation in different brain regions

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