Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults
Abstract Imbalances of blood biomarkers are associated with disease, and biomarkers may also vary non-pathologically across population groups. We described variation in concentrations of biomarkers of one-carbon metabolism, vitamin status, inflammation including tryptophan metabolism, and endothelia...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/6674002922064998994500a243671140 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:6674002922064998994500a243671140 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:6674002922064998994500a2436711402021-12-02T16:15:07ZEpidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults10.1038/s41598-021-93214-82045-2322https://doaj.org/article/6674002922064998994500a2436711402021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93214-8https://doaj.org/toc/2045-2322Abstract Imbalances of blood biomarkers are associated with disease, and biomarkers may also vary non-pathologically across population groups. We described variation in concentrations of biomarkers of one-carbon metabolism, vitamin status, inflammation including tryptophan metabolism, and endothelial and renal function among cancer-free older adults. We analyzed 5167 cancer-free controls aged 40–80 years from 20 cohorts in the Lung Cancer Cohort Consortium (LC3). Centralized biochemical analyses of 40 biomarkers in plasma or serum were performed. We fit multivariable linear mixed effects models to quantify variation in standardized biomarker log-concentrations across four factors: age, sex, smoking status, and body mass index (BMI). Differences in most biomarkers across most factors were small, with 93% (186/200) of analyses showing an estimated difference lower than 0.25 standard-deviations, although most were statistically significant due to large sample size. The largest difference was for creatinine by sex, which was − 0.91 standard-deviations lower in women than men (95%CI − 0.98; − 0.84). The largest difference by age was for total cysteine (0.40 standard-deviation increase per 10-year increase, 95%CI 0.36; 0.43), and by BMI was for C-reactive protein (0.38 standard-deviation increase per 5-kg/m2 increase, 95%CI 0.34; 0.41). For 31 of 40 markers, the mean difference between current and never smokers was larger than between former and never smokers. A statistically significant (p < 0.05) association with time since smoking cessation was observed for 8 markers, including C-reactive protein, kynurenine, choline, and total homocysteine. We conclude that most blood biomarkers show small variations across demographic characteristics. Patterns by smoking status point to normalization of multiple physiological processes after smoking cessation.Hana ZahedMattias JohanssonPer M. UelandØivind MidttunRoger L. MilneGraham G. GilesJonas ManjerMalte SandsvedenArnulf LanghammerElin Pettersen SørgjerdKjell GrankvistMikael JohanssonNeal D. FreedmanWen-Yi HuangChu ChenRoss PrenticeVictoria L. StevensYing WangLoic Le MarchandLynne R. WilkensStephanie J. WeinsteinDemetrius AlbanesQiuyin CaiWilliam J. BlotAlan A. ArslanAnne Zeleniuch-JacquotteXiao-Ou ShuWei ZhengJian-Min YuanWoon-Puay KohKala VisvanathanHoward D. SessoXuehong ZhangJ. Michael GazianoAnouar FanidiDavid MullerPaul BrennanFlorence GuidaHilary A. RobbinsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Hana Zahed Mattias Johansson Per M. Ueland Øivind Midttun Roger L. Milne Graham G. Giles Jonas Manjer Malte Sandsveden Arnulf Langhammer Elin Pettersen Sørgjerd Kjell Grankvist Mikael Johansson Neal D. Freedman Wen-Yi Huang Chu Chen Ross Prentice Victoria L. Stevens Ying Wang Loic Le Marchand Lynne R. Wilkens Stephanie J. Weinstein Demetrius Albanes Qiuyin Cai William J. Blot Alan A. Arslan Anne Zeleniuch-Jacquotte Xiao-Ou Shu Wei Zheng Jian-Min Yuan Woon-Puay Koh Kala Visvanathan Howard D. Sesso Xuehong Zhang J. Michael Gaziano Anouar Fanidi David Muller Paul Brennan Florence Guida Hilary A. Robbins Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults |
| description |
Abstract Imbalances of blood biomarkers are associated with disease, and biomarkers may also vary non-pathologically across population groups. We described variation in concentrations of biomarkers of one-carbon metabolism, vitamin status, inflammation including tryptophan metabolism, and endothelial and renal function among cancer-free older adults. We analyzed 5167 cancer-free controls aged 40–80 years from 20 cohorts in the Lung Cancer Cohort Consortium (LC3). Centralized biochemical analyses of 40 biomarkers in plasma or serum were performed. We fit multivariable linear mixed effects models to quantify variation in standardized biomarker log-concentrations across four factors: age, sex, smoking status, and body mass index (BMI). Differences in most biomarkers across most factors were small, with 93% (186/200) of analyses showing an estimated difference lower than 0.25 standard-deviations, although most were statistically significant due to large sample size. The largest difference was for creatinine by sex, which was − 0.91 standard-deviations lower in women than men (95%CI − 0.98; − 0.84). The largest difference by age was for total cysteine (0.40 standard-deviation increase per 10-year increase, 95%CI 0.36; 0.43), and by BMI was for C-reactive protein (0.38 standard-deviation increase per 5-kg/m2 increase, 95%CI 0.34; 0.41). For 31 of 40 markers, the mean difference between current and never smokers was larger than between former and never smokers. A statistically significant (p < 0.05) association with time since smoking cessation was observed for 8 markers, including C-reactive protein, kynurenine, choline, and total homocysteine. We conclude that most blood biomarkers show small variations across demographic characteristics. Patterns by smoking status point to normalization of multiple physiological processes after smoking cessation. |
| format |
article |
| author |
Hana Zahed Mattias Johansson Per M. Ueland Øivind Midttun Roger L. Milne Graham G. Giles Jonas Manjer Malte Sandsveden Arnulf Langhammer Elin Pettersen Sørgjerd Kjell Grankvist Mikael Johansson Neal D. Freedman Wen-Yi Huang Chu Chen Ross Prentice Victoria L. Stevens Ying Wang Loic Le Marchand Lynne R. Wilkens Stephanie J. Weinstein Demetrius Albanes Qiuyin Cai William J. Blot Alan A. Arslan Anne Zeleniuch-Jacquotte Xiao-Ou Shu Wei Zheng Jian-Min Yuan Woon-Puay Koh Kala Visvanathan Howard D. Sesso Xuehong Zhang J. Michael Gaziano Anouar Fanidi David Muller Paul Brennan Florence Guida Hilary A. Robbins |
| author_facet |
Hana Zahed Mattias Johansson Per M. Ueland Øivind Midttun Roger L. Milne Graham G. Giles Jonas Manjer Malte Sandsveden Arnulf Langhammer Elin Pettersen Sørgjerd Kjell Grankvist Mikael Johansson Neal D. Freedman Wen-Yi Huang Chu Chen Ross Prentice Victoria L. Stevens Ying Wang Loic Le Marchand Lynne R. Wilkens Stephanie J. Weinstein Demetrius Albanes Qiuyin Cai William J. Blot Alan A. Arslan Anne Zeleniuch-Jacquotte Xiao-Ou Shu Wei Zheng Jian-Min Yuan Woon-Puay Koh Kala Visvanathan Howard D. Sesso Xuehong Zhang J. Michael Gaziano Anouar Fanidi David Muller Paul Brennan Florence Guida Hilary A. Robbins |
| author_sort |
Hana Zahed |
| title |
Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults |
| title_short |
Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults |
| title_full |
Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults |
| title_fullStr |
Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults |
| title_full_unstemmed |
Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults |
| title_sort |
epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/6674002922064998994500a243671140 |
| work_keys_str_mv |
AT hanazahed epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT mattiasjohansson epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT permueland epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT øivindmidttun epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT rogerlmilne epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT grahamggiles epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT jonasmanjer epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT maltesandsveden epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT arnulflanghammer epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT elinpettersensørgjerd epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT kjellgrankvist epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT mikaeljohansson epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT nealdfreedman epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT wenyihuang epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT chuchen epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT rossprentice epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT victorialstevens epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT yingwang epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT loiclemarchand epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT lynnerwilkens epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT stephaniejweinstein epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT demetriusalbanes epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT qiuyincai epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT williamjblot epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT alanaarslan epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT annezeleniuchjacquotte epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT xiaooushu epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT weizheng epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT jianminyuan epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT woonpuaykoh epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT kalavisvanathan epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT howarddsesso epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT xuehongzhang epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT jmichaelgaziano epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT anouarfanidi epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT davidmuller epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT paulbrennan epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT florenceguida epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults AT hilaryarobbins epidemiologyof40bloodbiomarkersofonecarbonmetabolismvitaminstatusinflammationandrenalandendothelialfunctionamongcancerfreeolderadults |
| _version_ |
1718384293959434240 |