The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma

The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma

Hepatocellular carcinoma has one of the poorest survival rates amongst cancers. Here, the authors highlight the intra-tumour heterogeneity of this disease, finding that spatially closer tumour sectors are genetically more similar and that intra-hepatic metastasis is accompanied by rapid genetic dive...

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Autores principales: Weiwei Zhai, Tony Kiat-Hon Lim, Tong Zhang, Su-Ting Phang, Zenia Tiang, Peiyong Guan, Ming-Hwee Ng, Jia Qi Lim, Fei Yao, Zheng Li, Poh Yong Ng, Jie Yan, Brian K. Goh, Alexander Yaw-Fui Chung, Su-Pin Choo, Chiea Chuen Khor, Wendy Wei-Jia Soon, Ken Wing-Kin Sung, Roger Sik-Yin Foo, Pierce Kah-Hoe Chow
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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spelling oai:doaj.org-article:66747f4fa69e494a8136f9ada85205652021-12-02T14:42:39ZThe spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma10.1038/ncomms145652041-1723https://doaj.org/article/66747f4fa69e494a8136f9ada85205652017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14565https://doaj.org/toc/2041-1723Hepatocellular carcinoma has one of the poorest survival rates amongst cancers. Here, the authors highlight the intra-tumour heterogeneity of this disease, finding that spatially closer tumour sectors are genetically more similar and that intra-hepatic metastasis is accompanied by rapid genetic diversification.Weiwei ZhaiTony Kiat-Hon LimTong ZhangSu-Ting PhangZenia TiangPeiyong GuanMing-Hwee NgJia Qi LimFei YaoZheng LiPoh Yong NgJie YanBrian K. GohAlexander Yaw-Fui ChungSu-Pin ChooChiea Chuen KhorWendy Wei-Jia SoonKen Wing-Kin SungRoger Sik-Yin FooPierce Kah-Hoe ChowNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Weiwei Zhai
Tony Kiat-Hon Lim
Tong Zhang
Su-Ting Phang
Zenia Tiang
Peiyong Guan
Ming-Hwee Ng
Jia Qi Lim
Fei Yao
Zheng Li
Poh Yong Ng
Jie Yan
Brian K. Goh
Alexander Yaw-Fui Chung
Su-Pin Choo
Chiea Chuen Khor
Wendy Wei-Jia Soon
Ken Wing-Kin Sung
Roger Sik-Yin Foo
Pierce Kah-Hoe Chow
The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma
description Hepatocellular carcinoma has one of the poorest survival rates amongst cancers. Here, the authors highlight the intra-tumour heterogeneity of this disease, finding that spatially closer tumour sectors are genetically more similar and that intra-hepatic metastasis is accompanied by rapid genetic diversification.
format article
author Weiwei Zhai
Tony Kiat-Hon Lim
Tong Zhang
Su-Ting Phang
Zenia Tiang
Peiyong Guan
Ming-Hwee Ng
Jia Qi Lim
Fei Yao
Zheng Li
Poh Yong Ng
Jie Yan
Brian K. Goh
Alexander Yaw-Fui Chung
Su-Pin Choo
Chiea Chuen Khor
Wendy Wei-Jia Soon
Ken Wing-Kin Sung
Roger Sik-Yin Foo
Pierce Kah-Hoe Chow
author_facet Weiwei Zhai
Tony Kiat-Hon Lim
Tong Zhang
Su-Ting Phang
Zenia Tiang
Peiyong Guan
Ming-Hwee Ng
Jia Qi Lim
Fei Yao
Zheng Li
Poh Yong Ng
Jie Yan
Brian K. Goh
Alexander Yaw-Fui Chung
Su-Pin Choo
Chiea Chuen Khor
Wendy Wei-Jia Soon
Ken Wing-Kin Sung
Roger Sik-Yin Foo
Pierce Kah-Hoe Chow
author_sort Weiwei Zhai
title The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma
title_short The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma
title_full The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma
title_fullStr The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma
title_full_unstemmed The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma
title_sort spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/66747f4fa69e494a8136f9ada8520565
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