The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma

The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma

Hepatocellular carcinoma has one of the poorest survival rates amongst cancers. Here, the authors highlight the intra-tumour heterogeneity of this disease, finding that spatially closer tumour sectors are genetically more similar and that intra-hepatic metastasis is accompanied by rapid genetic dive...

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Bibliographic Details
Main Authors: Weiwei Zhai, Tony Kiat-Hon Lim, Tong Zhang, Su-Ting Phang, Zenia Tiang, Peiyong Guan, Ming-Hwee Ng, Jia Qi Lim, Fei Yao, Zheng Li, Poh Yong Ng, Jie Yan, Brian K. Goh, Alexander Yaw-Fui Chung, Su-Pin Choo, Chiea Chuen Khor, Wendy Wei-Jia Soon, Ken Wing-Kin Sung, Roger Sik-Yin Foo, Pierce Kah-Hoe Chow
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Science
Q
Online Access:https://doaj.org/article/66747f4fa69e494a8136f9ada8520565
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