HUMAN PAPILLOMAVIRUS INFECTION AND HEAD AND NECK CANCER PROGRESSION

Abstract. The aim of present study was to evaluate the influence of HPV infection on lymphogenic metastasis and survival of patients with head and neck squamous cell carcinoma. DNA was isolated from tumor tissue and tumor-adjacent normal epithelium of 64 patients with head and neck tumors of differe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	V. A. Bychkov, L. N. Urazova, E. G. Nikitina, O. V. Cheremisina, S. Y. Chizhevskaya
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	human papillomavirus tumor progression surviving, metastasis Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/6675bfa54fc84cca973c466865a8a328
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6675bfa54fc84cca973c466865a8a328
record_format	dspace
spelling	oai:doaj.org-article:6675bfa54fc84cca973c466865a8a3282021-11-22T07:09:46ZHUMAN PAPILLOMAVIRUS INFECTION AND HEAD AND NECK CANCER PROGRESSION2220-76192313-739810.15789/2220-7619-2014-2-162-166https://doaj.org/article/6675bfa54fc84cca973c466865a8a3282014-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/167https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. The aim of present study was to evaluate the influence of HPV infection on lymphogenic metastasis and survival of patients with head and neck squamous cell carcinoma. DNA was isolated from tumor tissue and tumor-adjacent normal epithelium of 64 patients with head and neck tumors of different localization. Detection of 12 HPV genotypes was carried out by the PCR using AmpliSens diagnostic kits (Russia). The association between HPV infection and clinical-pathological parameters of the patients was assessed. HPV was detected in tumor tissue and in the surrounding normal tissue in 22% of patients. The most common HPV genotypes were 16 and 51. No association of HPV infection with sex, age, location, TNM stage and differentiation grade was found. The Kaplan Meier method showed a tendency towards the improvement of the overall and recurrence-free survival of HPV-positive patients with head and neck cancer (p = 0.09 and p = 0.12 respectively). The multivariate survival analysis using Cox’s regression model showed that the patient’s age and the presence of lymph node metastases (p = 0.002) significantly influence on patient survival (p = 0.014 and p = 0.002 respectively).V. A. BychkovL. N. UrazovaE. G. NikitinaO. V. CheremisinaS. Y. ChizhevskayaSankt-Peterburg : NIIÈM imeni Pasteraarticlehuman papillomavirustumor progressionsurviving, metastasisInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 4, Iss 2, Pp 162-166 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	human papillomavirus tumor progression surviving, metastasis Infectious and parasitic diseases RC109-216
spellingShingle	human papillomavirus tumor progression surviving, metastasis Infectious and parasitic diseases RC109-216 V. A. Bychkov L. N. Urazova E. G. Nikitina O. V. Cheremisina S. Y. Chizhevskaya HUMAN PAPILLOMAVIRUS INFECTION AND HEAD AND NECK CANCER PROGRESSION
description	Abstract. The aim of present study was to evaluate the influence of HPV infection on lymphogenic metastasis and survival of patients with head and neck squamous cell carcinoma. DNA was isolated from tumor tissue and tumor-adjacent normal epithelium of 64 patients with head and neck tumors of different localization. Detection of 12 HPV genotypes was carried out by the PCR using AmpliSens diagnostic kits (Russia). The association between HPV infection and clinical-pathological parameters of the patients was assessed. HPV was detected in tumor tissue and in the surrounding normal tissue in 22% of patients. The most common HPV genotypes were 16 and 51. No association of HPV infection with sex, age, location, TNM stage and differentiation grade was found. The Kaplan Meier method showed a tendency towards the improvement of the overall and recurrence-free survival of HPV-positive patients with head and neck cancer (p = 0.09 and p = 0.12 respectively). The multivariate survival analysis using Cox’s regression model showed that the patient’s age and the presence of lymph node metastases (p = 0.002) significantly influence on patient survival (p = 0.014 and p = 0.002 respectively).
format	article
author	V. A. Bychkov L. N. Urazova E. G. Nikitina O. V. Cheremisina S. Y. Chizhevskaya
author_facet	V. A. Bychkov L. N. Urazova E. G. Nikitina O. V. Cheremisina S. Y. Chizhevskaya
author_sort	V. A. Bychkov
title	HUMAN PAPILLOMAVIRUS INFECTION AND HEAD AND NECK CANCER PROGRESSION
title_short	HUMAN PAPILLOMAVIRUS INFECTION AND HEAD AND NECK CANCER PROGRESSION
title_full	HUMAN PAPILLOMAVIRUS INFECTION AND HEAD AND NECK CANCER PROGRESSION
title_fullStr	HUMAN PAPILLOMAVIRUS INFECTION AND HEAD AND NECK CANCER PROGRESSION
title_full_unstemmed	HUMAN PAPILLOMAVIRUS INFECTION AND HEAD AND NECK CANCER PROGRESSION
title_sort	human papillomavirus infection and head and neck cancer progression
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/6675bfa54fc84cca973c466865a8a328
work_keys_str_mv	AT vabychkov humanpapillomavirusinfectionandheadandneckcancerprogression AT lnurazova humanpapillomavirusinfectionandheadandneckcancerprogression AT egnikitina humanpapillomavirusinfectionandheadandneckcancerprogression AT ovcheremisina humanpapillomavirusinfectionandheadandneckcancerprogression AT sychizhevskaya humanpapillomavirusinfectionandheadandneckcancerprogression
_version_	1718418045499604992

HUMAN PAPILLOMAVIRUS INFECTION AND HEAD AND NECK CANCER PROGRESSION

Ejemplares similares