Distinct Metagenomic Signatures in the SARS-CoV-2 Infection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause gastrointestinal symptoms in the patients, but the role of gut microbiota in SARS-CoV-2 infection remains unclear. Thus, in this study, we aim to investigate whether SARS-CoV-2 infection affects the composition and func...

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Autores principales:	Yijun Liu, Hongyang Zhang, Xiaojun Tang, Xuejun Jiang, Xiaojuan Yan, Xizhao Liu, Jiang Gong, Kenley Mew, Hao Sun, Xiufeng Chen, Zhen Zou, Chengzhi Chen, Jingfu Qiu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	SARS-CoV-2 COVID-19 gut microbiota microbial community metagenomic analysis Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/6676d29ce43d4d79a6c262023da8c45a
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spelling	oai:doaj.org-article:6676d29ce43d4d79a6c262023da8c45a2021-12-02T09:47:05ZDistinct Metagenomic Signatures in the SARS-CoV-2 Infection2235-298810.3389/fcimb.2021.706970https://doaj.org/article/6676d29ce43d4d79a6c262023da8c45a2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.706970/fullhttps://doaj.org/toc/2235-2988Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause gastrointestinal symptoms in the patients, but the role of gut microbiota in SARS-CoV-2 infection remains unclear. Thus, in this study, we aim to investigate whether SARS-CoV-2 infection affects the composition and function of gut microbiota. In this study, we demonstrated for the first time that significant shifts in microbiome composition and function were appeared in both SARS-CoV-2-infected asymptomatic and symptomatic cases. The relative abundance of Candidatus_Saccharibacteria was significantly increased, whereas the levels of Fibrobacteres was remarkably reduced in SARS-CoV-2-infected cases. There was one bacterial species, Spirochaetes displayed the difference between patients and asymptomatic cases. On the genus level, Tyzzerella was the key species that remarkably increased in both symptomatic and asymptomatic cases. Analyses of genome annotations further revealed SARS-CoV-2 infection resulted in the significant ‘functional dysbiosis’ of gut microbiota, including metabolic pathway, regulatory pathway and biosynthesis of secondary metabolites etc. We also identified potential metagenomic markers to discriminate SARS-CoV-2-infected symptomatic and asymptomatic cases from healthy controls. These findings together suggest gut microbiota is of possible etiological and diagnostic importance for SARS-CoV-2 infection.Yijun LiuHongyang ZhangXiaojun TangXuejun JiangXiaojuan YanXizhao LiuJiang GongKenley MewHao SunXiufeng ChenZhen ZouChengzhi ChenJingfu QiuFrontiers Media S.A.articleSARS-CoV-2COVID-19gut microbiotamicrobial communitymetagenomic analysisMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 COVID-19 gut microbiota microbial community metagenomic analysis Microbiology QR1-502
spellingShingle	SARS-CoV-2 COVID-19 gut microbiota microbial community metagenomic analysis Microbiology QR1-502 Yijun Liu Hongyang Zhang Xiaojun Tang Xuejun Jiang Xiaojuan Yan Xizhao Liu Jiang Gong Kenley Mew Hao Sun Xiufeng Chen Zhen Zou Chengzhi Chen Jingfu Qiu Distinct Metagenomic Signatures in the SARS-CoV-2 Infection
description	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause gastrointestinal symptoms in the patients, but the role of gut microbiota in SARS-CoV-2 infection remains unclear. Thus, in this study, we aim to investigate whether SARS-CoV-2 infection affects the composition and function of gut microbiota. In this study, we demonstrated for the first time that significant shifts in microbiome composition and function were appeared in both SARS-CoV-2-infected asymptomatic and symptomatic cases. The relative abundance of Candidatus_Saccharibacteria was significantly increased, whereas the levels of Fibrobacteres was remarkably reduced in SARS-CoV-2-infected cases. There was one bacterial species, Spirochaetes displayed the difference between patients and asymptomatic cases. On the genus level, Tyzzerella was the key species that remarkably increased in both symptomatic and asymptomatic cases. Analyses of genome annotations further revealed SARS-CoV-2 infection resulted in the significant ‘functional dysbiosis’ of gut microbiota, including metabolic pathway, regulatory pathway and biosynthesis of secondary metabolites etc. We also identified potential metagenomic markers to discriminate SARS-CoV-2-infected symptomatic and asymptomatic cases from healthy controls. These findings together suggest gut microbiota is of possible etiological and diagnostic importance for SARS-CoV-2 infection.
format	article
author	Yijun Liu Hongyang Zhang Xiaojun Tang Xuejun Jiang Xiaojuan Yan Xizhao Liu Jiang Gong Kenley Mew Hao Sun Xiufeng Chen Zhen Zou Chengzhi Chen Jingfu Qiu
author_facet	Yijun Liu Hongyang Zhang Xiaojun Tang Xuejun Jiang Xiaojuan Yan Xizhao Liu Jiang Gong Kenley Mew Hao Sun Xiufeng Chen Zhen Zou Chengzhi Chen Jingfu Qiu
author_sort	Yijun Liu
title	Distinct Metagenomic Signatures in the SARS-CoV-2 Infection
title_short	Distinct Metagenomic Signatures in the SARS-CoV-2 Infection
title_full	Distinct Metagenomic Signatures in the SARS-CoV-2 Infection
title_fullStr	Distinct Metagenomic Signatures in the SARS-CoV-2 Infection
title_full_unstemmed	Distinct Metagenomic Signatures in the SARS-CoV-2 Infection
title_sort	distinct metagenomic signatures in the sars-cov-2 infection
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6676d29ce43d4d79a6c262023da8c45a
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Distinct Metagenomic Signatures in the SARS-CoV-2 Infection

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