VITAMIN D DEFICIENCY PANDEMIC, A REALITY OR AN OVER DIAGNOSIS? NEED TO RETHINK VITAMIN D DEFICIENCY CUT OFF LEVELS

Objective: To determine clinical decision limits (cut off points) for vitamin D deficiency based on secondary hyperparathyroidism. Study Design: Cross sectional study. Place and Duration of Study: This study was conducted in the Department of Chemical Pathology and Endocrinology, Armed Forces...

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Autores principales:	Afshan Bibi, Naveed Asif, Zujaja Hina Haroon, Aamir Ijaz, Asif Nawaz, Qurat Ul Ain Atif
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	cut off levels ipth secondary hyperparathyroidism vitamin d deficiency 25(oh) d Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6677203c41a94ae9b5c13261fd7d65f9
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spelling	oai:doaj.org-article:6677203c41a94ae9b5c13261fd7d65f92021-12-02T17:18:25ZVITAMIN D DEFICIENCY PANDEMIC, A REALITY OR AN OVER DIAGNOSIS? NEED TO RETHINK VITAMIN D DEFICIENCY CUT OFF LEVELS0030-96482411-8842https://doaj.org/article/6677203c41a94ae9b5c13261fd7d65f92020-10-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/5558https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine clinical decision limits (cut off points) for vitamin D deficiency based on secondary hyperparathyroidism. Study Design: Cross sectional study. Place and Duration of Study: This study was conducted in the Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology (AFIP), from Dec 2016 to May 2017. Methodology: One hundred and sixteen subjects, aged 18 to 60 years, of either gender, with vitamin D levels less than 50nmol/L, were consecutively included in the study. Results: Serum 25(OH) D had inverse relation with plasma iPTH level (r=-0.597, p<0.0001). Thirty five percent of the subjects with vitamin D level below 50nmol/L had secondary hyperparathyroidism. However, the frequency of secondary hyperparathyroidism was 52% in subjects with 25 (OH) D level less than 25nmol/L compared with 28% having serum vitamin D levels of 25-40nmol/L. None of the patient with Vitamin D level above 40nmol/L had secondary hyperparathyroidism. Receiver operating characteristic (ROC) curve showed that 25(OH) D level of 25.5nmol/L as an optimal cut off level for vitamin D deficiency based on Secondary Hyperparathyroidism with area under the curve (AUC) was 0.761. Conclusion: High frequency of secondary hyperparathyroidism in adults with vitamin D levels under 25nmol/L necessitates reconsideration of vitamin D cutoff limit for bone health.Afshan BibiNaveed AsifZujaja Hina HaroonAamir IjazAsif NawazQurat Ul Ain AtifArmy Medical College Rawalpindiarticlecut off levelsipthsecondary hyperparathyroidismvitamin d deficiency25(oh) dMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 5, Pp 1327-1331 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	cut off levels ipth secondary hyperparathyroidism vitamin d deficiency 25(oh) d Medicine R Medicine (General) R5-920
spellingShingle	cut off levels ipth secondary hyperparathyroidism vitamin d deficiency 25(oh) d Medicine R Medicine (General) R5-920 Afshan Bibi Naveed Asif Zujaja Hina Haroon Aamir Ijaz Asif Nawaz Qurat Ul Ain Atif VITAMIN D DEFICIENCY PANDEMIC, A REALITY OR AN OVER DIAGNOSIS? NEED TO RETHINK VITAMIN D DEFICIENCY CUT OFF LEVELS
description	Objective: To determine clinical decision limits (cut off points) for vitamin D deficiency based on secondary hyperparathyroidism. Study Design: Cross sectional study. Place and Duration of Study: This study was conducted in the Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology (AFIP), from Dec 2016 to May 2017. Methodology: One hundred and sixteen subjects, aged 18 to 60 years, of either gender, with vitamin D levels less than 50nmol/L, were consecutively included in the study. Results: Serum 25(OH) D had inverse relation with plasma iPTH level (r=-0.597, p<0.0001). Thirty five percent of the subjects with vitamin D level below 50nmol/L had secondary hyperparathyroidism. However, the frequency of secondary hyperparathyroidism was 52% in subjects with 25 (OH) D level less than 25nmol/L compared with 28% having serum vitamin D levels of 25-40nmol/L. None of the patient with Vitamin D level above 40nmol/L had secondary hyperparathyroidism. Receiver operating characteristic (ROC) curve showed that 25(OH) D level of 25.5nmol/L as an optimal cut off level for vitamin D deficiency based on Secondary Hyperparathyroidism with area under the curve (AUC) was 0.761. Conclusion: High frequency of secondary hyperparathyroidism in adults with vitamin D levels under 25nmol/L necessitates reconsideration of vitamin D cutoff limit for bone health.
format	article
author	Afshan Bibi Naveed Asif Zujaja Hina Haroon Aamir Ijaz Asif Nawaz Qurat Ul Ain Atif
author_facet	Afshan Bibi Naveed Asif Zujaja Hina Haroon Aamir Ijaz Asif Nawaz Qurat Ul Ain Atif
author_sort	Afshan Bibi
title	VITAMIN D DEFICIENCY PANDEMIC, A REALITY OR AN OVER DIAGNOSIS? NEED TO RETHINK VITAMIN D DEFICIENCY CUT OFF LEVELS
title_short	VITAMIN D DEFICIENCY PANDEMIC, A REALITY OR AN OVER DIAGNOSIS? NEED TO RETHINK VITAMIN D DEFICIENCY CUT OFF LEVELS
title_full	VITAMIN D DEFICIENCY PANDEMIC, A REALITY OR AN OVER DIAGNOSIS? NEED TO RETHINK VITAMIN D DEFICIENCY CUT OFF LEVELS
title_fullStr	VITAMIN D DEFICIENCY PANDEMIC, A REALITY OR AN OVER DIAGNOSIS? NEED TO RETHINK VITAMIN D DEFICIENCY CUT OFF LEVELS
title_full_unstemmed	VITAMIN D DEFICIENCY PANDEMIC, A REALITY OR AN OVER DIAGNOSIS? NEED TO RETHINK VITAMIN D DEFICIENCY CUT OFF LEVELS
title_sort	vitamin d deficiency pandemic, a reality or an over diagnosis? need to rethink vitamin d deficiency cut off levels
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doaj.org/article/6677203c41a94ae9b5c13261fd7d65f9
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VITAMIN D DEFICIENCY PANDEMIC, A REALITY OR AN OVER DIAGNOSIS? NEED TO RETHINK VITAMIN D DEFICIENCY CUT OFF LEVELS

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