Altered diversity and composition of gut microbiota in Wilson's disease

Abstract Wilson’s disease (WD) is an autosomal recessive inherited disorder of chronic copper toxicosis with high mortality and disability. Recent evidence suggests a correlation between dysbiosis in gut microbiome and multiple diseases such as genetic and metabolic disease. However, the impact of i...

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Autores principales:	Xiangsheng Cai, Lin Deng, Xiaogui Ma, Yusheng Guo, Zhiting Feng, Minqi Liu, Yubin Guan, Yanting Huang, Jianxin Deng, Hongwei Li, Hong Sang, Fang Liu, Xiaorong Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/66784e5f90404c62b31f23f1de57971c
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spelling	oai:doaj.org-article:66784e5f90404c62b31f23f1de57971c2021-12-02T12:33:15ZAltered diversity and composition of gut microbiota in Wilson's disease10.1038/s41598-020-78988-72045-2322https://doaj.org/article/66784e5f90404c62b31f23f1de57971c2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78988-7https://doaj.org/toc/2045-2322Abstract Wilson’s disease (WD) is an autosomal recessive inherited disorder of chronic copper toxicosis with high mortality and disability. Recent evidence suggests a correlation between dysbiosis in gut microbiome and multiple diseases such as genetic and metabolic disease. However, the impact of intestinal microbiota polymorphism in WD have not been fully elaborated and need to be explore for seeking some microbiota benefit for WD patients. In this study, the 16S rRNA sequencing was performed on fecal samples from 14 patients with WD and was compared to the results from 16 healthy individuals. The diversity and composition of the gut microbiome in the WD group were significantly lower than those in healthy individuals. The WD group presented unique richness of Gemellaceae, Pseudomonadaceae and Spirochaetaceae at family level, which were hardly detected in healthy controls. The WD group had a markedly lower abundance of Actinobacteria, Firmicutes and Verrucomicrobia, and a higher abundance of Bacteroidetes, Proteobacteria, Cyanobacteria and Fusobacteria than that in healthy individuals. The Firmicutes to Bacteroidetes ratio in the WD group was significantly lower than that of healthy control. In addition, the functional profile of the gut microbiome from WD patients showed a lower abundance of bacterial groups involved in the host immune and metabolism associated systems pathways such as transcription factors and ABC-type transporters, compared to healthy individuals. These results implied dysbiosis of gut microbiota may be influenced by the host metabolic disorders of WD, which may provide a new understanding of the pathogenesis and new possible therapeutic targets for WD.Xiangsheng CaiLin DengXiaogui MaYusheng GuoZhiting FengMinqi LiuYubin GuanYanting HuangJianxin DengHongwei LiHong SangFang LiuXiaorong YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiangsheng Cai Lin Deng Xiaogui Ma Yusheng Guo Zhiting Feng Minqi Liu Yubin Guan Yanting Huang Jianxin Deng Hongwei Li Hong Sang Fang Liu Xiaorong Yang Altered diversity and composition of gut microbiota in Wilson's disease
description	Abstract Wilson’s disease (WD) is an autosomal recessive inherited disorder of chronic copper toxicosis with high mortality and disability. Recent evidence suggests a correlation between dysbiosis in gut microbiome and multiple diseases such as genetic and metabolic disease. However, the impact of intestinal microbiota polymorphism in WD have not been fully elaborated and need to be explore for seeking some microbiota benefit for WD patients. In this study, the 16S rRNA sequencing was performed on fecal samples from 14 patients with WD and was compared to the results from 16 healthy individuals. The diversity and composition of the gut microbiome in the WD group were significantly lower than those in healthy individuals. The WD group presented unique richness of Gemellaceae, Pseudomonadaceae and Spirochaetaceae at family level, which were hardly detected in healthy controls. The WD group had a markedly lower abundance of Actinobacteria, Firmicutes and Verrucomicrobia, and a higher abundance of Bacteroidetes, Proteobacteria, Cyanobacteria and Fusobacteria than that in healthy individuals. The Firmicutes to Bacteroidetes ratio in the WD group was significantly lower than that of healthy control. In addition, the functional profile of the gut microbiome from WD patients showed a lower abundance of bacterial groups involved in the host immune and metabolism associated systems pathways such as transcription factors and ABC-type transporters, compared to healthy individuals. These results implied dysbiosis of gut microbiota may be influenced by the host metabolic disorders of WD, which may provide a new understanding of the pathogenesis and new possible therapeutic targets for WD.
format	article
author	Xiangsheng Cai Lin Deng Xiaogui Ma Yusheng Guo Zhiting Feng Minqi Liu Yubin Guan Yanting Huang Jianxin Deng Hongwei Li Hong Sang Fang Liu Xiaorong Yang
author_facet	Xiangsheng Cai Lin Deng Xiaogui Ma Yusheng Guo Zhiting Feng Minqi Liu Yubin Guan Yanting Huang Jianxin Deng Hongwei Li Hong Sang Fang Liu Xiaorong Yang
author_sort	Xiangsheng Cai
title	Altered diversity and composition of gut microbiota in Wilson's disease
title_short	Altered diversity and composition of gut microbiota in Wilson's disease
title_full	Altered diversity and composition of gut microbiota in Wilson's disease
title_fullStr	Altered diversity and composition of gut microbiota in Wilson's disease
title_full_unstemmed	Altered diversity and composition of gut microbiota in Wilson's disease
title_sort	altered diversity and composition of gut microbiota in wilson's disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/66784e5f90404c62b31f23f1de57971c
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Altered diversity and composition of gut microbiota in Wilson's disease

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